Search Result

Search Results for " mdk "

Targets

Compounds

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T28001	MDK-6983	MDK-6983,Compound 6k,Autophagy inhibitor 6k,MDK6983	Autophagy
	MDK-6983 (MDK-6983) is an inhibitor of autophagy and disrupts the dynamics of actin cytoskeleton in human melanoma cells.		Autophagy
T19765	MDK-4025		Calcium Channel
	MDK-4025 is an inhibitor of the high voltage-activated (HVA) Ca2+ current in pyramidal neurons.		Calcium Channel
T25780	MDK-4823	LMPTP-IN-23,LMPTP-IN 23,MDK4823,LMPTP-IN23,MDK 4823
	MDK-4823, also known as LMPTP inhibitor1, is a potent low-molecular-weight tyrosine phosphatase (LMPTP) inhibitor. LMPTP is highly expressed in insulin-target tissues. LMPTP promotes diabetes and insulin resistance in ob...
T25779	MDK-4683	MDK 4683,CA IX/XII Inhibitor
	MDK-4683, also known as CA IX/XII Inhibitor, is a hCA IX and hCA XII inhibitor.
T33261	MDK-5432	AMPA stabilizer (R,R)-2a,MDK 5432
	MDK-5432, also known as AMPA stabilizer (R,R)-2a, is the most potent AMPA stabilizer.
T5310	TR-14035	MDK-1191	Integrin
	TR-14035 (MDK-1191) is a dual antagonist of α4β7/α4β1 integrins (IC50s: 7/87nM).		Integrin
T27998	MDK-4204	Anticancer AgentI,MDK 4204,Anticancer Agent I,MDK4204,Anticancer Agent-I
	MDK-4204, an anticancer agent, shows significant anti-cancer activity with IC50 values of 8.8 µM and 9.5 µM in PC-3 and DU-145 cells, respectively.
T27997	MDK-3345	MDK 3345,Mcl-1 Inhibitor11,Mcl-1 Inhibitor 11,Mcl-1 Inhibitor-11
	MDK-3345 is a reversible covalent inhibitor for Mcl-1.
T27999	MDK-4624	AMPKα1 activator C13,C13, Compound 13
	MDK-4624 is a AMPKα1 activator. MDK-4624 inhibits Helicobacter pylori-induced oxidative stresses and gastric epithelial cell apoptosis. MDK-4624 attenuates dexamethasone-induced osteoblast cell death. MDK-4624 potently i...
T5093	Pim1/AKK1-IN-1	LKB1/AAK1 dual inhibitor,MDK-2275	Pim , Hippo pathway
	Pim1/AKK1-IN-1 (LKB1/AAK1 dual inhibitor) is a potent multi-kinase inhibitor with Kd values of 35 nM/53 nM/75 nM/380 nM for Pim1/AKK1/MST2/LKB1 respectively, and also inhibits MPSK1 and TNIK.		Pim , Hippo pathway
T27991	MDK-0757	Hsp90-IN-89,MDK0757
	MDK-0757 is a novel inhibitor of heat shock protein 90 (Hsp90).
T27990	MDK-0738	AKR1C3-IN-14a,AKR1C3 IN 14a
	MDK-0738 is a potent and selective aldo-keto reductase 1C3 inhibitor.
T27995	MDK-3046	HK-inhibitor-2,MDK3046,HK inhibitor 2
	MDK-3046 is a YycG histidine kinase (HK) inhibitor with potent antibiofim activity against Staphylococcus epidermidis.
T27994	MDK-2959	PTPsigma inhibitor2,PTPsigma inhibitor 2,PTPsigmainhibitor2
	MDK-2959 is a potent inhibitor of protein tyrosine phosphatase sigma (PTPsigma).
T27996	MDK-3298	Mcl-1 Inhibitor-5,Mcl-1 Inhibitor 5,MDK3298,Mcl-1 Inhibitor5
	MDK-3298 is a reversible covalent inhibitor of Mcl-1, a target of protein-protein interaction (PPI).
T1772	MDK83190	Apoptosis Activator 2	Apoptosis , Caspase
	MDK83190 (Apoptosis Activator 2) is a potent apoptosis activator, induceing caspase-3 activation, PARP cleavage, and DNA fragmentation .		Apoptosis , Caspase
T28000	MDK49781	MDK-49781,MDK 49781
	MDK49781 is a useful chemical intermediate for drug synthesis.
T27992	MDK08445	MDK-08445,MDK 08445
	MDK08445 is an important intermediate or precursor for the synthesis of Cefiderocol, a potent siderophore cephalosporin antibiotic.
T28002	MDK71803	MDK-71803,Cefiderocol-intermediate, Cefiderocol-precursor,MDK 71803
	MDK71803 is an important intermediate or precursor for the synthesis of Cefiderocol, a potent siderophore cephalosporin antibiotic with a catechol moiety on the 3-position side chain.
T28004	MDK8228	PF-CBP/BRD4,MDK-8228,MDK 8228
	MDK8228 is an inhibitor of CBP/p300 and BRD4 bromodomain. MDK8228 downregulates IL-6, IL-ß and IFN-ß in macrophages.
T24438	MDK5466	MDK-5466,MDK 5466,E21,Flt3-IN-III,Flt3 Inhibitor III
	MDK5466 is an Flt3 inhibitor that acts by preventing glutamate-induced cell death.
T28003	MDK7677	Cathepsin B Inhinitor-17,MDK 7677
	MDK7677 is a selective inhibitor of cathepsin B endopeptidase and exopeptidase activities.
T9460	IMDK		PI3K
	iMDK quarterhydrate is a potent PI3K inhibitor that inhibits the growth factor MDK (also known as midkine or MK). iMDK quarterhydrate synergistically inhibits non-small cell lung cancer (NSCLC) with MEK inhibitors withou...		PI3K
T9033	BTYNB	MDK6620,BTYNB IMP1 Inhibitor	Others , c-Myc , NF-κB
	BTYNB (MDK6620) is an inhibitor of the oncofetal mRNA-binding protein IMP1 (IC50 = 5 μM for IMP1 binding to c-Myc mRNA). MDK6620 downregulates β-TrCP1 mRNA and reduces activation of nuclear transcriptional factors-kappa ...		Others , c-Myc , NF-κB
T16529	BEBT-908	PI3Kα inhibitor 1,MDK9521	PI3K , HDAC
	BEBT-908 (PI3Kα inhibitor 1) is a selective PI3Kα inhibitor (IC50 <0.1 μM). BEBT-908 also inhibits HDAC (0.1 μM≤IC50≤1 μM).		PI3K , HDAC
T8412	(S,R,S)-AHPC	VH032-NH2,MDK7526,VHL ligand 1	Others , Ligand for E3 Ligase
	(S,R,S)-AHPC (VH032-NH2) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC is potential useful for the targeted degradation of the androgen receptor.		Others , Ligand for E3 Ligase
T70141	MDK80908
	MDK80908, also known as PPARalpha/gamma agonist N15, is a dual PPARα/γ agonist, ameliorating insulin resistance and gluconeogenesis in vivo and vitro. MDK80908 has CAS#1821380-90-8.
T70069	MDK6465
	MDK6465, also known as PCSK9-IN-8b, is a novel liver-targeted inhibitor of ribosomal synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9). MDK6465 has CAS#1900686-46-5. the last 4 digits are used in its na...
T27989	MDK0734	Cathepsin B Inhinitor-42
	MDK0734 is a selective inhibitor of cathepsin B endopeptidase and exopeptidase activities.
T70599	Asem F-18
	Asem F-18 is a radiolabeled antagonist for imaging the α7-nicotinic acetylcholine receptor with PET .
T69916	MDK3673
	MDK3673, also known as Olfr895-Agonist-10, is a novel specific agonist of odorant receptor 895 (Olfr895).
T70601	MDK03855
	MDK03855, also known as A2AR antagonist 19, is an adenosine A2A receptor (A2AR) antagonist. MDK03855 has CAS#1454903-85-5. The last five digit of CAS# was used for name.
T69915	GX-585
	GX-585 is a novel potent inhibitor of NaV1.7 and highly selective against NaV1.5, having limited selectivity against NaV1.1 and NaV1.2.
T70068	AT-1015 hydrochloride monohydrate
	AT-1015 hydrochloride monohydrate is a serotonin (5-HT)2 receptor antagonist that blocks vascular and platelet 5-HT2A receptors.
T3190	PIK-inhibitors	MDK34597	PI3K
	PIK-inhibitors (MDK34597) is a pan PI3K inhibitors, an analog of PI-103.		PI3K
T70140	D 22888
	D 22888 is a PDE4 inhibitor.
T68559	OUN58101
	OUN58101, also known as MDK-8101, also known as BI-D, is a RSV L-protein inhibitor. OUN58101 was first reported in patnet WO 2005042530. This product has no formal name at the moment. For the convenience of communicati...
T24439	MDK6204	CLK1/2 IN 2,CLK1/2IN2,CLK1/2-inhibitor-2,CLK1/2-IN-2,CLK1/2 inhibitor 2
	MDK6204 is a selective inhibitor of CLK1 and CLK2.
T4198	T.cruzi-IN-1	MDK1088,T.cruzi Inhibitor	Antibiotic , Parasite
	T.cruzi-IN-1 (MDK1088) is a Trypanosoma cruzi inhibitor.		Antibiotic , Parasite
T61627	IMDK quarterhydrate
	iMDK quarterhydrate, a potent PI3K inhibitor, is effective in inhibiting the growth factor MDK (also known as midkine or MK) while demonstrating suppression of non-small cell lung cancer (NSCLC). In combination with a ME...
T7082	HDAC8-IN-1		HDAC
	MDK-7933 (HDAC8-IN-1) is a HDAC8 inhibitor with an IC50 of 27.2 nM in cancer cell lines. MDK-7933 shows antiproliferative effects toward several human lung cancer cell lines (A549, H1299, and CL1-5). HDAC8-IN-1 exhibits ...		HDAC

Compounds

MDK-6983

T28001

Synonym: MDK-6983,Compound 6k,Autophagy inhibitor 6k,MDK6983

Target: Calcium Channel

MDK-4823

T25780

Synonym: LMPTP-IN-23,LMPTP-IN 23,MDK4823,LMPTP-IN23,MDK 4823

Target:

MDK-4683

T25779

Synonym: MDK 4683,CA IX/XII Inhibitor

Target:

MDK-5432

T33261

Synonym: AMPA stabilizer (R,R)-2a,MDK 5432

Synonym: Anticancer AgentI,MDK 4204,Anticancer Agent I,MDK4204,Anticancer Agent-I

Target:

MDK-3345

T27997

Synonym: MDK 3345,Mcl-1 Inhibitor11,Mcl-1 Inhibitor 11,Mcl-1 Inhibitor-11

Target:

MDK-4624

T27999

Synonym: AMPKα1 activator C13,C13, Compound 13

Target:

Pim1/AKK1-IN-1

T5093

Synonym: LKB1/AAK1 dual inhibitor,MDK-2275

Target: Pim, Hippo pathway

MDK-0757

T27991

Synonym: Hsp90-IN-89,MDK0757

Target:

MDK-0738

T27990

Synonym: AKR1C3-IN-14a,AKR1C3 IN 14a

Target:

MDK-3046

T27995

Synonym: HK-inhibitor-2,MDK3046,HK inhibitor 2

Target:

MDK-2959

T27994

Synonym: PTPsigma inhibitor2,PTPsigma inhibitor 2,PTPsigmainhibitor2

Target:

MDK-3298

T27996

Synonym: Mcl-1 Inhibitor-5,Mcl-1 Inhibitor 5,MDK3298,Mcl-1 Inhibitor5

Target:

MDK83190

T1772

Synonym: Apoptosis Activator 2

Target: Apoptosis, Caspase

MDK49781

T28000

Synonym: MDK-49781,MDK 49781

Target:

MDK08445

T27992

Synonym: MDK-08445,MDK 08445

Target:

MDK71803

T28002

Synonym: MDK-71803,Cefiderocol-intermediate, Cefiderocol-precursor,MDK 71803

Target:

MDK8228

T28004

Synonym: PF-CBP/BRD4,MDK-8228,MDK 8228

Target:

MDK5466

T24438

Synonym: MDK-5466,MDK 5466,E21,Flt3-IN-III,Flt3 Inhibitor III

Target:

MDK7677

T28003

Synonym: Cathepsin B Inhinitor-17,MDK 7677

Synonym: MDK6620,BTYNB IMP1 Inhibitor

Target: Others, c-Myc, NF-κB

BEBT-908

T16529

Synonym: PI3Kα inhibitor 1,MDK9521

Target: PI3K, HDAC

(S,R,S)-AHPC

T8412

Synonym: VH032-NH2,MDK7526,VHL ligand 1

Target: Others, Ligand for E3 Ligase

Synonym: Cathepsin B Inhinitor-42

AT-1015 hydrochloride monohydrate

Synonym: CLK1/2 IN 2,CLK1/2IN2,CLK1/2-inhibitor-2,CLK1/2-IN-2,CLK1/2 inhibitor 2

Target:

T.cruzi-IN-1

T4198

Synonym: MDK1088,T.cruzi Inhibitor

Target: Antibiotic, Parasite

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPK-00812	Midkine Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic acid-responsive gene during embryogenesis, but currently viewed as a multifaceted factor contributing to both normal tissue hom...
TMPK-00024	Midkine Protein, Human, Recombinant (His & Avi), Biotinylated	Human	E. coli
	Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic acid-responsive gene during embryogenesis, but currently viewed as a multifaceted factor contributing to both normal tissue hom...
TMPK-00023	Midkine Protein, Human, Recombinant (His & Avi)	Human	E. coli
	Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic acid-responsive gene during embryogenesis, but currently viewed as a multifaceted factor contributing to both normal tissue hom...
TMPY-01786	EphB4 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	EphB4 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 84.7 kDa and the accession number is P54761-1.
TMPY-01787	EphB4 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	EphB4 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 59 kDa and the accession number is P54761-1.
TMPY-01784	EphB3 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	EphB3 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57 kDa and the accession number is P54754.
TMPK-00898	EphB3 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Although EphB3 expression is down-regulated in colorectal cancer (CRC) cells compared with normal intestinal epithelial cells.EphB3 is down-regulated in CRC compared to normal mucosa. Hypermethylation of CpG island is co...
TMPY-02172	Midkine Protein, Human, Recombinant	Human	Baculovirus Insect Cells
	Midkine (MK or MDK) also known as neurite growth-promoting factor 2 (NEGF2) is a basic heparin-binding growth factor of low molecular weight, and forms a family with pleiotrophin. Midkine is a retinoic acid-responsive, h...