lncap — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T36841	IPI-9119		Fatty Acid Synthase
	IPI-9119 is an orally active, selective and irreversible FASN inhibitor (IC50 = 0.3 nM).		Fatty Acid Synthase
T2430	HPOB		Apoptosis , HDAC
	HPOB is an effective and specific HDAC6 inhibitor (IC50: 56 nM), >30-fold selectivity over other HDACs.		Apoptosis , HDAC
T12928	SK33		Androgen Receptor
	SK33 is a potent and tissue selective anti-androgen agent. SK33 reduces androgen receptor (AR) transcriptional activity.		Androgen Receptor
T6002	Enzalutamide	MDV3100	Androgen Receptor , Autophagy
	Enzalutamide (MDV3100) is an androgen receptor (AR) antagonist (IC50=36 nM in LNCaP). Enzalutamide activates autophagy, has antitumor activity, and is commonly used in the treatment of desmoplasia-resistant prostate canc...		Androgen Receptor , Autophagy
T21740	RD162		Androgen Receptor
	RD162 is a non-steroidal antiandrogen (NSAA) specifically binding to the androgen receptor (AR).		Androgen Receptor
T9246	JNJ-63576253		Androgen Receptor
	JNJ-63576253 is a Clinical Stage Androgen Receptor Antagonist for F877L Mutant and Wild-Type Castration-Resistant Prostate Cancer (mCRPC).		Androgen Receptor
T6400	AZD3514		Androgen Receptor
	AZD3514 is a potent and oral androgen receptor downregulator with Ki of 2.2 μM and has ability of reducing AR protein expression.Phase 1.		Androgen Receptor
T4697	ABBV-744	ABBV744	Epigenetic Reader Domain , HIV Protease
	ABBV-744 is a BDII-selective BET bromodomain inhibitor that inhibits BRD2/3/4. It is used in the research on inflammatory diseases, cancer, and AIDS.		Epigenetic Reader Domain , HIV Protease
T1267	Abacavir	Epzicom,Ziagen,Abacavir sulfate	Apoptosis , HIV Protease , Reverse Transcriptase
	Abacavir (Ziagen) is a nucleoside reverse transcriptase inhibitor analog of guanosine. This agent decreases HIV viral loads, retards or prevents the damage to the immune system, and reduces the risk of developing AIDS.		Apoptosis , HIV Protease , Reverse Transcriptase
T9179	CLP-3094	2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BE	Androgen Receptor
	CLP-3094 (2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BE) is a potent androgen receptor BF3 (binding function 3) inhibitor. BF3-IN-1 inhibits AR transcriptional activity with IC50 of 4 μM. CLP-3094 is a selective and potent GP...		Androgen Receptor
T10359	AR antagonist 1		Androgen Receptor , Ligand for E3 Ligase , Ligands for Target Protein for PROTAC
	AR antagonist 1 is a potent antagonist of the androgen receptor. It binds to E3 ligase ligands with weak binding affinities to VHL protein in the synthesis of PROTAC ARD-266.
T6367	Abacavir sulfate	Abacavir Hemisulfate,1592U89,ABC sulfate,Ziagen	Apoptosis , HIV Protease , Reverse Transcriptase
	Abacavir sulfate (Ziagen) , a nucleoside analogue, effectively utilize its antiviral activity		Apoptosis , HIV Protease , Reverse Transcriptase
T60019	VPC-70063	Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)-	Apoptosis , PARP , c-Myc
	VPC-70063 (Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)-) is an inhibitor of c-Myc-MAX. VPC-70063 exhibits Myc-Max transcriptional activity inhibition of 106% with an IC50 of 8.9 μM and Myc-Max/UBE2C do...		Apoptosis , PARP , c-Myc
T6909	NSC348884		Apoptosis , p53
	NSC348884 is a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis, inhibits cell proliferation at an IC50 of 1.7-4.0 μM in distinct cancer cell lines.		Apoptosis , p53
T8933	JNJ-63576253 free base	TRC253,JNJ-63576253	Androgen Receptor
	JNJ-63576253 free base (TRC253) is a potent and orally active full antagonist of androgen receptor (AR), with IC50s of 37 and 54 nM for F877L mutant AR and wild-type AR in LNCaP cells. JNJ-63576253 can be used for the re...		Androgen Receptor
T29110	VPC-13163	2,3-dihydro-2,3'-Bi-1H-indole,VPC13163,NSC52361,NSC 52361,VPC 13163	Others
	VPC-13163 (NSC-52361) has strong anti-proliferative activity against LNCaP and Enzalutamide-resistant prostate cancer cell lines (MR49F) whereas it did not affect the growth of AR independent PC3 cell line. It also inhib...		Others
T67705	MTOR inhibitor 9a
	mTOR inhibitor 9a inhibited the growth of human LNCap cells with an ic50 of 80 nm. 1-methyl-3 -{4-[4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)thieno[3,2-d]pyrimidin-2-yl]phenyl}urea may have antitumor activity.
T41288	Myristoleic acid	cis-9-tetradecenoic acid,9-Tetradecenoic acid,(Z)-Tetradec-9-enoic acid	Apoptosis
	Myristoleic acid (9-Tetradecenoic acid) is a cytotoxic component in the extract from Serenoa repens. Myristoleic acid induces apoptosis and necrosis in human prostatic LNCaP cells.		Apoptosis
T4601	9-Methoxycanthin-6-one		Others
	9-Methoxycanthin-6-one has anti-tumour activity, exhibits cytotoxic activity towards KB, LU-1, LNCaP, HL-60 cancer cells and other human cancer cell lines with IC50 values around 1-4 μg/mL.		Others
T2795	Amygdalin	Laetrile	Others
	Amygdalin (Laetrile) has antifibrotic, antitumor, anti-inflammatory and analgesic effects, amygdalin joint HSYA could inhibit the degeneration of the endplate chondrocytes derived from intervertebral discs of rats induce...		Others