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RD162

Catalog No. T21740 CAS 915087-27-3

RD162 is a non-steroidal antiandrogen (NSAA) specifically binding to the androgen receptor (AR).

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RD162, CAS 915087-27-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 39.00
5 mg	In stock	$ 122.00
10 mg	In stock	$ 197.00
25 mg	In stock	$ 413.00
50 mg	In stock	$ 615.00
100 mg	In stock	$ 876.00
1 mL * 10 mM (in DMSO)	In stock	$ 147.00

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Purity: 97.74%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	RD162 is a non-steroidal antiandrogen (NSAA) specifically binding to the androgen receptor (AR).
In vitro	RD162 has little to no binding to the progesterone, estrogen, or glucocorticoid receptors. RD162 (1-10 μM) suppressed growth and induces apoptosis in the human prostate cancer cell line VCaP which had endogenous AR gene amplification[1].
In vivo	RD162 (20 mg/kg) is ∼50 percent bioavailable after oral delivery with a serum half-life of about 30 hours. RD162 (10 mg/kg; oral gavage) causes all tumors regressed. RD162 (0.1, 1, 10 mg/kg; oral gavage) consistently reduces luciferase activity with 10 mg/kg/day human LNCaP/AR xenografts grown in castrated male mice whereas lower doses of 0.1 and 1.0 mg/kg/day has minimal effect. RD162 substantially reduces cellular proliferation after 5 days[1].

Molecular Weight	476.45
Formula	C22H16F4N4O2S
CAS No.	915087-27-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (104.94 mM)

References and Literature

1. Chris Tran, et al. Development of a second-generation antiandrogen for treatment of advanced prostate cancer. Science. 2009 May 8;324(5928):787-90.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Drug Repurposing Compound Library Bioactive Compounds Library Max FDA-Approved Drug Library Target-Focused Phenotypic Screening Library Bioactive Compound Library FDA-Approved & Pharmacopeia Drug Library Approved Drug Library Anti-Cancer Compound Library

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Related compounds with same targets

LGD-2226 ARD-2128 Ganoderol B MI-136 YXG-158 Testosterone propionate Galloylpaeoniflorin D4-abiraterone

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

RD162 915087-27-3 Endocrinology/Hormones Androgen Receptor inhibit prostate VCaP Inhibitor castration RD 162 NSAA RD-162 LNCaP diarylthiohydantoin orally inhibitor

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