lck — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T1811	WH-4-023	KIN112,KIN001-112,Dual LCK/SRC inhibitor	Src
	WH-4-023 (Dual LCK/SRC inhibitor) is a potent and orally active Lck/Src inhibitor. It also potently inhibits SIK.		Src
T15726	Lck Inhibitor		Others
	Lck Inhibitor is effective inhibitors of Lck (IC50: 7 nM).		Others
T15725	Lck inhibitor 2		Others
	Lck inhibitor 2 is a bis-anilinopyrimidine inhibitor of tyrosine kinases including LCK, BTK, LYN, SYK, and TXK (IC50s: 13nM, 9nM, 3nM, 26nM, and 2nM for Lck, Btk, Lyn, Btk, and Txk respectively).		Others
T8888	Lck-IN-1
	Lck-IN-1 is a potent inhibitor of lymphocyte protein tyrosine kinase (Lck) [1].
T68349	Lck inhibitor II
	Lck inhibitor II is a cell-permeable, ATP binding site-targeting, tri-substituted pyrimidine that acts as a highly potent Lck (lymphocyte specific kinase) inhibitor
T72586	Lck Inhibitor III
	Lck Inhibitor III, a potent inhibitor of Lck, exhibits an IC50 value of 867 nM. Additionally, this compound effectively inhibits IL-2 synthesis in Jurkat cells, demonstrating an IC50 of 1.270 μM.
T1764	Adezmapimod	PB 203580,RWJ 64809,SB203580	Mitophagy , p38 MAPK , Autophagy
	Adezmapimod (SB 203580) is a p38 MAPK inhibitor (IC50=0.3-0.5 μM) that is selective and ATP-competitive. Adezmapimod possesses autophagy and mitochondrial autophagy activating activity. Adezmapimod displays more than 100...		Mitophagy , p38 MAPK , Autophagy
TP1890L1	MLCK inhibitor peptide 18 acetate	MLCK inhibitor peptide 18 acetate(224579-74-2 free base)	Serine/threonin kinase
	MLCK inhibitor peptide 18 acetate is a selective competitive inhibitor of myosin light chain kinase (IC50 = 50 nM). Displays 4000-fold selectivity over CaM kinase II and does not inhibit PKA. Cell permeable.		Serine/threonin kinase
TP2482	LCKLSL acetate	LCKLSL acetate(533902-29-3 free base)	Annexin A
	LCKLSL acetate is a competitive annexin A2 (AnxA2) inhibitor. LCKLSL acetate potently inhibits the binding of tissue plasminogen activator (tPA) to AnxA2 and the generation of plasmin. LCKLSL acetate has anti-angiogenic ...		Annexin A
T40614	LCKLSL
	LCKLSL, an N-terminal hexapeptide, acts as a competitive inhibitor of annexin A2 (AnxA2), effectively preventing the binding of tissue plasminogen activator (tPA) to AnxA2 while also inhibiting the generation of plasmin....
T81151	SK-MLCK M13
	SK-MLCK M13 is a biologically active peptide representing the calmodulin (CaM)-binding domain of CaM target proteins, where CaM is a ubiquitous Ca2+ binding protein.
T78015	LCKLSL hydrochloride
	LCKLSL hydrochloride, an N-terminal hexapeptide and competitive annexin A2 (AnxA2) inhibitor, effectively disrupts the interaction between tissue plasminogen activator (tPA) and AnxA2. It additionally hinders plasmin gen...
TP1890	MLCK inhibitor peptide 18
	Selective competitive inhibitor of myosin light chain kinase (IC50 = 50 nM). Displays 4000-fold selectivity over CaM kinase II and does not inhibit PKA. Cell permeable.
T16760	RK-24466	KIN 001-51	Src
	RK-24466 (KIN 001-51) is a selective and potent inhibitor of Lck, inhibits Lck (64-509) and LckCD isoforms with IC50s of less than 1 and 2 nM, respectively.		Src
T6196	PP1	EI 275,AGL 1872	Apoptosis , EGFR , Bcr-Abl , Src , c-Kit
	PP1 (AGL 1872), a specific and effective Src inhibitor, is with IC50 for Lck/Fyn is 5 nM/ 6 nM, respectively.		Apoptosis , EGFR , Bcr-Abl , Src , c-Kit
TQ0132	A 419259 trihydrochloride	RK 20449 trihydrochloride	Src
	A 419259 trihydrochloride (RK 20449 trihydrochloride) is an Src family kinases inhibitor (IC50s: 9 nM, 3 nM and 3 nM for Src, Lck and Lyn).		Src
T6266	PP2	AGL 1879,AG 1879,AGL 1879	EGFR , Tyrosine Kinases , JAK , Src
	PP2 (AG 1879,AGL 1879) is a effective inhibitor of Lck/Fyn (IC50:4/5 nM) , ~100-fold less potent to EGFR, inactive for ZAP-70, PKA and JAK2.		EGFR , Tyrosine Kinases , JAK , Src
T4133	CCT196969		Raf , Src
	CCT196969 is a novel orally available, pan-RAF inhibitor with anti-SRC activity. It also inhibits SRC, LCK, and the p38 MAPKs.		Raf , Src
T6078	Saracatinib	AZD0530	EGFR , Src , BTK , Autophagy
	Saracatinib (AZD0530) (AZD0530) is an effective Src inhibitor (IC50: 2.7 nM), and effective to Lck, Fyn, Lyn, Blk, Fgr and c-Yes.		EGFR , Src , BTK , Autophagy
T9017	HPK1-IN-2	Thieno[2,3-b]pyridin-6(7H)-one, 4-amino-5-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-HPK1-IN-2,HPK1-IN-2	Others , FLT , Src
	HPK1-IN-2 (Thieno[2,3-b]pyridin-6(7H)-one, 4-amino-5-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-HPK1-IN-2) is a potent and orally active inhibitor of hematopoietic progenitor kinase-1 (HPK1; IC50<0.05 μΜ). It also...		Others , FLT , Src