Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Lck Inhibitor is effective inhibitors of Lck (IC50: 7 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | 5 days | $ 91.00 | |
50 mg | 6-8 weeks | $ 753.00 | |
100 mg | 6-8 weeks | $ 1,420.00 |
Description | Lck Inhibitor is effective inhibitors of Lck (IC50: 7 nM). |
In vitro | Lck Inhibitor exhibited good potency in the T-cell receptor-induced IL-2 secretion assay (IL- 2) and also inhibited subsequent T-cell proliferation (T-cell prolif.) in the same human T -cells. |
In vivo | A once-daily dose of 25was administered orally at 10, 30, and 60 mg/kg from day 9 to day 17. Paw volume was measured daily from day 9 through day 18. The compound showed a dose-dependent inhibition of arthritis, with an ED50 estimated at 24 mg/kg (Figure 6). Based on the measured plasma levels from the three-dose groups, the exposure of 25 at the ED50 was estimated to be 2.7 μM·h (Cmax≈ 0.7 μM) [1]. |
Molecular Weight | 530.62 |
Formula | C31H30N8O |
CAS No. | 847950-09-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (188.46 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Lck Inhibitor 847950-09-8 Others inhibitor inhibit