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RK-24466

Catalog No. T16760   CAS 213743-31-8
Synonyms: KIN 001-51

RK-24466 (KIN 001-51) is a selective and potent inhibitor of Lck, inhibits Lck (64-509) and LckCD isoforms with IC50s of less than 1 and 2 nM, respectively.

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RK-24466 Chemical Structure
RK-24466, CAS 213743-31-8
Pack Size Availability Price/USD Quantity
1 mg In stock $ 60.00
5 mg In stock $ 147.00
10 mg In stock $ 239.00
25 mg In stock $ 468.00
50 mg In stock $ 697.00
100 mg In stock $ 992.00
1 mL * 10 mM (in DMSO) In stock $ 162.00
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Purity: 99.26%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description RK-24466 (KIN 001-51) is a selective and potent inhibitor of Lck, inhibits Lck (64-509) and LckCD isoforms with IC50s of less than 1 and 2 nM, respectively.
Targets&IC50 LckCD:2 nM (IC50), Lck (64-509):<1 nM (IC50)
In vitro RK-24466, a lymphocyte-specific protein tyrosine kinase (Lck) inhibitor, significantly inhibited both VSMC proliferation and migration. RK-24466 suppresses VSMC proliferation and migration via down-regulating the protein kinase B (Akt) and extracellular signal regulated kinase (ERK) pathways, and it significantly decreased the expression of proliferating cell nuclear antigen (PCNA) and cyclin D1 and, the phosphorylation of retinoblastoma protein (pRb). Additionally, RK-24466 suppressed the migration of VSMCs from endothelium-removed aortic rings, as well as neointima formation following rat carotid balloon injury. The present study identified RK-24466 as a potent VSMC proliferation and migration inhibitor and warrants further studies to elucidate its more detailed molecular mechanisms, such as its primary target, and to further validate its in vivo efficacy as a therapeutic agent for pathologic vascular conditions, such as restenosis and atherosclerosis[1].
Synonyms KIN 001-51
Molecular Weight 370.45
Formula C23H22N4O
CAS No. 213743-31-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 40 mg/mL (107.97 mM), sonification is recommended.

TargetMolReferences and Literature

1. Seo HH, et al. 7-cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d] pyrimidin-4-ylamine inhibits the proliferation and migration of vascular smooth muscle cells by suppressing ERK and Akt pathways. Eur J Pharmacol. 2017 Mar 5;798:35-42. 2. Arnold LD, et al. Pyrrolo[2,3-d]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck I. Bioorg Med Chem Lett. 2000 Oct 2;10(19):2167-70.

Related compound libraries

This product is contained In the following compound libraries:
Tyrosine Kinase Inhibitor Library NO PAINS Compound Library Reprogramming Compound Library Bioactive Compounds Library Max Bioactive Compound Library Anti-Pancreatic Cancer Compound Library Inhibitor Library Anti-Cancer Compound Library Anti-Cancer Metabolism Compound Library Angiogenesis related Compound Library

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Keywords

RK-24466 213743-31-8 Angiogenesis Tyrosine Kinase/Adaptors Src Inhibitor inhibit RK 24466 KIN 001-51 RK24466 inhibitor

 

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