Powder: -20°C for 3 years | In solvent: -80°C for 1 year
RK-24466 (KIN 001-51) is a selective and potent inhibitor of Lck, inhibits Lck (64-509) and LckCD isoforms with IC50s of less than 1 and 2 nM, respectively.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 60.00 | |
5 mg | In stock | $ 147.00 | |
10 mg | In stock | $ 239.00 | |
25 mg | In stock | $ 468.00 | |
50 mg | In stock | $ 697.00 | |
100 mg | In stock | $ 992.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 162.00 |
Description | RK-24466 (KIN 001-51) is a selective and potent inhibitor of Lck, inhibits Lck (64-509) and LckCD isoforms with IC50s of less than 1 and 2 nM, respectively. |
Targets&IC50 | LckCD:2 nM (IC50), Lck (64-509):<1 nM (IC50) |
In vitro | RK-24466, a lymphocyte-specific protein tyrosine kinase (Lck) inhibitor, significantly inhibited both VSMC proliferation and migration. RK-24466 suppresses VSMC proliferation and migration via down-regulating the protein kinase B (Akt) and extracellular signal regulated kinase (ERK) pathways, and it significantly decreased the expression of proliferating cell nuclear antigen (PCNA) and cyclin D1 and, the phosphorylation of retinoblastoma protein (pRb). Additionally, RK-24466 suppressed the migration of VSMCs from endothelium-removed aortic rings, as well as neointima formation following rat carotid balloon injury. The present study identified RK-24466 as a potent VSMC proliferation and migration inhibitor and warrants further studies to elucidate its more detailed molecular mechanisms, such as its primary target, and to further validate its in vivo efficacy as a therapeutic agent for pathologic vascular conditions, such as restenosis and atherosclerosis[1]. |
Synonyms | KIN 001-51 |
Molecular Weight | 370.45 |
Formula | C23H22N4O |
CAS No. | 213743-31-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 40 mg/mL (107.97 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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RK-24466 213743-31-8 Angiogenesis Tyrosine Kinase/Adaptors Src Inhibitor inhibit RK 24466 KIN 001-51 RK24466 inhibitor