ikkβ — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T63919	IKKβ-IN-1
	IKKβ-IN-1 is a potent, orally active inhibitor of IkappaB (IKK-β) (IC50: 0.20 μM). IKKβ-IN-1 reduces the inhibition of PGE2 and TNF-α production in murine macrophages. IKKβ-IN-1 protects mice from infection shock-induced...
T6150	TAK-715		p38 MAPK , Casein Kinase , JNK
	TAK-715 is a p38 MAPK inhibitor for p38α.		p38 MAPK , Casein Kinase , JNK
TQ0306	MLN120B		IκB/IKK
	MLN120B is a selective and ATP competitive IKKβ inhibitor (IC50: 60 nM).		IκB/IKK
T5209	INH14		IκB/IKK
	INH14 is a novel inhibitor of the IKKα/β-dependent TLR inflammatory response (IC50s: 8.97/3.59 μM for IKKα/IKKβ).		IκB/IKK
T8910	2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC		IκB/IKK
	2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC is Inhibitior of IKKβ.		IκB/IKK
T6141	IMD-0354	IKK2 Inhibitor V,IMD 0354	IκB/IKK
	IMD-0354 (IKK2 Inhibitor V) is an IKKβ inhibitor and inhibits IκBα phosphorylation in NF-κB pathway.		IκB/IKK
T125120	Cyclo(L-Pro-L-Val)		IκB/IKK , NOS , NF-κB , COX , Antibacterial
	Cyclo(L-Pro-L-Val), a 2,5-diketopiperazine extracted from the fruits of Mycobacterium chiliolyticum AZ2 and Mycobacterium leprae, possesses anti-inflammatory activity and virulence activity against phytopathogenic microo...		IκB/IKK , NOS , NF-κB , COX , Antibacterial
T2765	Rosmarinic acid	Labiatenic acid,Rosemary acid	Apoptosis , IκB/IKK , MAO , Endogenous Metabolite , Transferase , Monoamine Oxidase
	Rosmarinic acid (Labiatenic acid) is widely found in plants and has antioxidant, anti-inflammatory, and antibacterial activities. It inhibits MAO-A, MAO-B, and COMT with IC50 of 50.1, 184.6, and 26.7 μM respectively.
T14567	BI605906		IκB/IKK
	BI605906 is an inhibitor of IKKβ. When assayed at 0.1 mM ATP, the IC50 value is 380 nM.		IκB/IKK
T10237	ACHP Hydrochloride	IKK-2 Inhibitor VIII	IκB/IKK
	ACHP Hydrochloride (IKK-2 Inhibitor VIII) is a highly potent and selective IKK-β inhibitor with an IC50 of 8.5 nM.		IκB/IKK
T14669	BMS-066		IκB/IKK , Tyrosine Kinases
	BMS-066 is an IKKβ/Tyk2 pseudokinase inhibitor. With IC50s of 9 nM and 72 nM, respectively.		IκB/IKK , Tyrosine Kinases
T23137	PF 184		Others
	IKKβ inhibitor		Others
T10472L	Bay 65-1942 free base		IκB/IKK
	Bay 65-1942 free base is an inhibitor of ATP-competitive and selective IKKβ.		IκB/IKK
T14508	Bay 65-1942 hydrochloride		IκB/IKK
	Bay 65-1942 hydrochloride is an inhibitor of ATP-competitive and selective IKKβ.		IκB/IKK
T10472	Bay 65-1942 (R form)	Bay 65-1942 R form	Others
	Bay 65-1942 R form is the less active R-form of Bay 65-1942. Bay 65-1942 is a selective and ATP-competitive IKKβ inhibitor.		Others
T72208	1-Dehydro-[10]-gingerdione
	1-Dehydro-[10]-gingerdione inhibits IKKβ activity by targeting its activation loop, thereby preventing IKKβ-mediated phosphorylation of IκBα in macrophages stimulated by agonists. Furthermore, this compound suppresses LP...
T61059	IKK-IN-4
	IKK-IN-4 is a potent and selective inhibitor of IkappaB kinase 2 with IC 50 values of 45 and 650 nM against IKKβ and IKKα, respectively [1].
T71747	IKKß-IN-124
	IKKß-IN-124 is an allosteric inhibitor of IκBα phosphorylation and NF-κB transcriptional activity through selective capture of the inactive conformation and hence blockade of IKKβ S177/S181 phosphorylation.
T37449	SR 12460
	SR 12460 is a mimetic of the IκB kinase β (IKKβ) NEMO/IKKγ-binding domain (NBD) that inhibits the protein-protein interaction between the IKK complex subunits NF-κB essential modulator (NEMO/IKKγ) and IKKβ.1It inhibits T...
T40700	IKK-IN-3
	IKK-IN-3 is a highly potent and selective inhibitor of IkappaB kinase 2 (IKK2 or IKKβ). It exhibits impressive inhibitory activity against IKK2 (IC50 = 19 nM), while also demonstrating significant efficacy against IKK1 (...