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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T1967 | AZD-3463 | ALK/IGF1R inhibitor | Apoptosis , IGF-1R , ALK , Autophagy |
AZD-3463 (ALK/IGF1R inhibitor) , an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency. | |||
T38502 | IGF-1R inhibitor-2 | ||
IGF-1R inhibitor-2 (example 121) is a compound that inhibits the insulin-like growth factor-1 receptor (IGF-1R). By downregulating the IGF-1R, it has the potential to reverse the transformed phenotype of tumor cells and ... | |||
T2693 | AG1024 | Tyrphostin AG 1024,Tyrphostin,AGS 200 | Apoptosis , IGF-1R |
AG1024 (Tyrphostin) suppresses IGF-1R autophosphorylation(IC50=7 μM), and is less potent for IR(IC50=57 μM). | |||
T76810 | Ganitumab | AMG 479 | IGF-1R |
Ganitumab (AMG 479) is a highly potent monoclonal antibody to type 1 insulin-like growth factor receptor (IGF1R). Ganitumab is recognized to bind to IGF1R at low concentration with KD value of 0.22 nM. Ganitumab can inhi... | |||
T13564L | AZ7550 hydrochloride | AZ7550 hydrochloride (1421373-99-0 free base) | EGFR , IGF-1R |
AZ7550 hydrochloride (AZ7550 hydrochloride ), an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM). | |||
T13564 | AZ7550 | MLK , FAK , EGFR , FLT , Tyrosine Kinases , PYK2 , MNK , IGF-1R , ACK , BTK , ALK , Drug Metabolite | |
AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM). | |||
T13564L2 | AZ7550 trimesylate salt | AZ7550 Mesylate,AZ7550 trimesylate salt (1421373-99-0 free base) | MLK |
AZ7550 trimesylate salt (AZ7550 Mesylate) is the active metabolite of ositinib, AZ7550 trimesylate salt inhibits IGF1R activity and can be used in the study of non-small cell lung cancer. | |||
T3S0027 | Picropodophyllotoxin | AXL 1717,Picropodophyllin | IGF-1R |
Picropodophyllotoxin (AXL 1717) is a cyclolignan alkaloid found in the mayapple plant family (Podophyllum peltatum), and a small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF1R) with potential anti... | |||
T6943 | Picropodophyllin | AXL1717,Picropodophyllin (PPP),Picropodophyllotoxin,PPP | Apoptosis , IGF-1R |
Picropodophyllin (Picropodophyllin (PPP)) (PPP) is a specific IGF-1R inhibitor (IC50: 1 nM). Picropodophyllin specifically inhibits the activity and downregulates the cellular expression of IGF1R without interfering with... | |||
T76746 | Figitumumab | ||
Figitumumab (CP-751871) is a fully human monoclonal antibody targeting the insulin-like growth factor 1 receptor (IGF1R) with high potency. By inhibiting the binding of IGF1 to IGF1R, figitumumab achieves an IC50 value o... | |||
T11654 | Indirubin Derivative E804 | Others | |
Indirubin Derivative E804 is an effective inhibitor of IGF1R, which has an IC50 value of 0.65. | |||
T80871 | Veligrotug | IGF-1R | |
Veligrotug is a chimeric monoclonal antibody of the IgG1-kappa class that targets the insulin-like growth factor 1 receptor (IGF1R, CD221) [1]. | |||
T38584 | ALK-IN-12 | ||
ALK-IN-12 is a highly potent and orally active inhibitor of anaplastic lymphoma kinase (ALK), demonstrating an exceptional IC50 value of 0.18 nM. Additionally, ALK-IN-12 displays inhibitory activity against insulin-like ... | |||
T69221 | BMS-554417 | ||
BMS-554417 is a novel inhibitor of IGF-IR, which inhibits IGF-IR and insulin receptor kinase activity and proliferation in vitro, and reduces tumor xenograft size in vivo. In a series of carcinoma cell lines, the IC50 fo... |