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AZ7550 trimesylate salt

Catalog No. T13564L2   CAS 2319837-99-3
Synonyms: AZ7550 Mesylate, AZ7550 trimesylate salt (1421373-99-0 free base)

AZ7550 trimesylate salt (AZ7550 Mesylate) is the active metabolite of ositinib, AZ7550 trimesylate salt inhibits IGF1R activity and can be used in the study of non-small cell lung cancer.

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AZ7550 trimesylate salt Chemical Structure
AZ7550 trimesylate salt, CAS 2319837-99-3
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Purity: 99.24%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description AZ7550 trimesylate salt (AZ7550 Mesylate) is the active metabolite of ositinib, AZ7550 trimesylate salt inhibits IGF1R activity and can be used in the study of non-small cell lung cancer.
Targets&IC50 ERB4:195 nM, MNK2:228 nM, IGF-1R:1.6 μM, MLK1:88 nM, IRR:840 nM, ACK1:156 nM, BRK:843 nM, FLT3:302 nM, ALK:420 nM, FES:449 nM
In vitro AZ7550 trimesylate salt (Compound 28) demonstrates a potency and selectivity profile broadly similar to the parent compound AZD9291. Inhibiting the double mutant (DM) cell line H1975, activating mutant (AM) cell line PC9, and wild-type (WT) cell line LoVo, AZ7550 trimesylate salt exhibits IC50s of 45, 26, and 786 nM, respectively. Moreover, it inhibits the antiproliferative cell lines H1975 (DM), PC9 (AM), and Calu3 (WT) with GI50s of 19, 15, and 537 nM, respectively[1].
Synonyms AZ7550 Mesylate, AZ7550 trimesylate salt (1421373-99-0 free base)
Molecular Weight 773.9
Formula C30H43N7O11S3
CAS No. 2319837-99-3

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 20 mg/mL (25.84 mM), Sonication is recommended.

TargetMolReferences and Literature

1. Finlay MR, et al. Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor. J Med Chem. 2014 Oct 23;57(20):8249-67.

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Keywords

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