hedgehog — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T35537	Hedgehog Antagonist VIII
	Hedgehog (Hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of Smoothened. In vertebrates, this ultimately leads to the activation of the zinc-finger transcript...
T3156	Ciliobrevin A	Hedgehog Pathway Inhibitor 4,HPI-4	Hedgehog/Smoothened
	Ciliobrevin A (HPI-4) is an inhibitor of hedgehog signaling pathway with an IC50 <10 μM.		Hedgehog/Smoothened
T75148	Hedgehog IN-3
	Hedgehog IN-3 (compound 3), with an IC50 value of 0.01 µM, serves as a hedgehog pathway inhibitor, proving beneficial for cancer research applications [1].
T79055	Hedgehog IN-2
	Hedgehog IN-2 (Compound 20) functions as an inhibitor of the Hedgehog signaling pathway, exhibiting an IC50 of <0.003 μM in C3H10T1/2 cells [1].
T15183	Dynarrestin		Hedgehog/Smoothened
	Dynarrestin is an inhibitor of cytoplasmic dyneins 1 and 2. Dynarrestin suppresses hedgehog (Hh)-dependent proliferation of neuronal precursors and tumor cells. It inhibits dynein 1-driven microtubule gliding in vitro pl...		Hedgehog/Smoothened
T3588	JK184		Hedgehog/Smoothened
	JK184 is a potent Hedgehog (Hh) pathway inhibitor.		Hedgehog/Smoothened
T14965	Ciliobrevin D		ATPase , Hedgehog/Smoothened
	Ciliobrevin D is a AAA+ ATPase motor cytoplasmic dynein inhibitor. Ciliobrevin D inhibits Hedgehog (Hh) signaling and primary cilia formation and it also inhibits dynein-dependent microtubule gliding and ATPase activity ...		ATPase , Hedgehog/Smoothened
T6891	MK-4101		Apoptosis , Hedgehog/Smoothened , Smo
	MK-4101, an effective inhibitor of the Hedgehog pathway, has anti-tumor activity through the induction of extensive apoptosis and inhibition of proliferation in tumor cells.		Apoptosis , Hedgehog/Smoothened , Smo
T9531	MRT-14		Smo
	MRT-14 is a potent Smo antagonist and can be used in several types of cancers linked to abnormal Hh signaling studies.		Smo
T2450	SANT-1	SANT 1	Hedgehog/Smoothened , Smo
	SANT-1 directly binds to Smoothened (Smo) receptor (Kd: 1.2 nM) and inhibits Smo agonist effects (IC50: 20 nM).		Hedgehog/Smoothened , Smo
T2825	Cyclopamine	11-Deoxojervine	Hedgehog/Smoothened , Endogenous Metabolite , Smo
	Cyclopamine (11-Deoxojervine), a Smoothened (Smo) antagonist (IC50: 46 nM in TM3Hh12 cells), belongs to the group of steroidal jerveratrum alkaloids.		Hedgehog/Smoothened , Endogenous Metabolite , Smo
T3912	Saikosaponin B1		Others
	Saponin activator. Activates release of Prostaglandin E2 in vitro. Anti-inflammatory agent. Orally active. Active in vivo and in vitro.		Others
T3363	Jervine	Iervin,11-Ketocyclopamine,Jerwiny	Hedgehog/Smoothened , Smo
	The biological activity of Jervine (Jerwiny) is mediated via its interaction with the 7 passes transmembrane protein Smoothened. Jervine binds with and inhibits smoothened, which is an integral part of the Hedgehog signa...		Hedgehog/Smoothened , Smo
T22814	GSA-10		Hedgehog/Smoothened
	Smoothened (Smo) receptor agonist		Hedgehog/Smoothened
T2590	Vismodegib	Erivedge,GDC-0449,RG 3616	Hedgehog/Smoothened , ABC , Autophagy
	Vismodegib (GDC-0449) is a hedgehog pathway inhibitor (IC50: 3 nM). It also inhibits P-gp (IC50: 3.0 μM), ABCG2 (IC50: 1.4 μM).		Hedgehog/Smoothened , ABC , Autophagy
T1011	Itraconazole	R51211	P450 , Hedgehog/Smoothened , Antibiotic , Autophagy , Antifungal
	Itraconazole (R51211) is a triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis.
T20723	LGE-899	Sonidegib metabolite M48,LGE 899	Drug Metabolite
	LGE-899 (Sonidegib metabolite M48) is a main metabolite of Sonidegib which is an inhibitor of the hedgehog pathway. The Tmax of LGE-899(60 h) is much longer than Sonidegib.		Drug Metabolite
T26296	Triparanol	MER-29,NSC 65345,NSC-65345,NSC65345	Apoptosis , Hedgehog/Smoothened
	Triparanol (NSC-65345) interferes with posttranslational modification of Hedgehog signaling molecules as well as the sterol sensing domain of its receptor PTCH1, leading to down-regulation of Hedgehog signaling. Triparan...		Apoptosis , Hedgehog/Smoothened
T24754	Hh-Ag1.5	SAG-1.5,SAG1.5,SAG 1.5	Hedgehog/Smoothened
	Hh-Ag1.5 (SAG-1.5) is a potent Hedgehog (Hh) agonist (EC50: 1 nM) and Smoothened (Smo) receptor agonist, with an EC50 of 1 nM and Ki values between 0.5 and 2.3 nM for Smo. Hh-Ag1.5-mediated reprogramming breaks the quies...		Hedgehog/Smoothened
T1155	Mebendazole	Telmin,Mebenvet,Vermox,Pantelmin	Apoptosis , Microtubule Associated , Parasite
	Mebendazole (Mebenvet) is a hedgehog inhibitor, used as an antihelminthic.		Apoptosis , Microtubule Associated , Parasite