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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T2320 | Indacaterol | Adrenergic Receptor | |
Indacaterol (Onbrez; Arcapta) is a β2-Adrenergic Agonist. The mechanism of action of indacaterol is as an Adrenergic beta2-Agonist. | |||
T3860 | Isoliquiritin apioside | MMP , p38 MAPK , NF-κB | |
Isoliquiritin apioside, isolated from Glycyrrhizae radix rhizome, significantly decreases PMA-induced increases in MMP9 activities and suppresses PMA-induced activation of MAPK and NF-κB. Isoliquiritin apioside auppresse... | |||
T20819 | Ammonium iron(III) citrate | Ferric ammonium citrate | Others , Ferroptosis |
Ammonium iron(III) citrate (Ferric ammonium citrate) is a physiological form of non-ferritin-bound iron that causes intracellular iron overload leading to cellular iron death and enhances protein production. | |||
T1239 | Indacaterol maleate | QAB149 | Adrenergic Receptor |
Indacaterol maleate (QAB149) is an ultra-long-acting β-adrenoceptor agonist. | |||
T4S21320 | ISOGINKGETIN | 4',4'''-Dimethylamentoflavone | MMP , Others |
1. ISOGINKGETIN (4',4'''-Dimethylamentoflavone), a compound derived from the leaves of Ginkgo biloba, to up-regulate adiponectin secretion with potency comparable to that of rosiglitazone, a known modulator of adiponecti... | |||
T8649 | TMBIM6 antagonist-1 | BAX-inhibitor-1,BIA | mTOR |
TMBIM6 antagonist-1 (BAX-inhibitor-1) is a bax inhibitor | |||
T2586 | Cabozantinib | XL184,BMS-907351 | Apoptosis , VEGFR , FLT , c-Met/HGFR , c-RET , TAM Receptor , c-Kit |
Cabozantinib (XL184) is a multi-targeted tyrosine kinase receptor inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt3 (IC50=0.035/1.3/4.6/7/11.3 nM). Cabozantinib exhibits both antitumor and antiangiogenic activity... | |||
T5164 | Cabozantinib hydrochloride | XL184,Cabozantinib hydrochloride (849217-68-1(free base)),BMS-907351 | VEGFR , FLT , c-Met/HGFR , TAM Receptor , c-Kit , ROR |
Cabozantinib hydrochloride (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt4 (IC50s: 0.035, 1.3, 4.6, 7 and 6 nM). | |||
T36675 | ERK Inhibitor | ||
ERK inhibitor is a cell-permeable inhibitor that binds ERK2 near its docking domain (KD = 5 μM). This prevents its interaction with protein substrates without inhibiting catalytic activity. ERK inhibitor blocks ERK-speci... | |||
T64357 | FA16 | FA 16,FA-16 | Ferroptosis |
FA16 is a selective, metabolically stable ferroptosis inducer with an IC50 value of 1.26 μM.FA16 is a derivative of 2-(trifluoromethyl)benzimidazole.FA16 inhibits the cystine/glutamate inverse transporter protein (system... | |||
T74796 | PROTAC GPX4 degrader-1 | ||
PROTAC GPX4 Degrader-1 (DC-2) is a PROTAC-based compound that efficiently degrades GPX4, demonstrating a degradation concentration (DC 50) of 0.03 μM in HT1080 cells [1]. | |||
T83017 | Antiproliferative agent-40 | ||
Antiproliferative agent-40 (Compound 9) effectively inhibits the proliferation of HT1080 and MCF-7 cancer cells, displaying IC50 values of 52 μM and 8.2 μM, respectively [1]. | |||
T83018 | Antiproliferative agent-39 | ||
Antiproliferative Agent-39 (Compound 12) effectively inhibits the proliferation of various cancer cell lines, including A549, SNU-638, Col2, HT1080, and MCF-7, with respective IC50 values of 11, 25, 14, 11, and 6.3 μM [1... | |||
T25006 | AGI-14100 | AGI 14100 | Dehydrogenase |
AGI-14100 is a novel and orally available mIDH1 inhibitor.AGI-14100 is used for the treatment of primary human myeloid leukemia. | |||
TN2029 | P-Hydroxy-5,6-dehydrokawain | 4'-Hydroxydehydrokawain | Others |
p-Hydroxy-5,6-dehydrokawain (4'-Hydroxydehydrokawain) is isolated from Kawain. | |||
T18635 | PROTAC RAR Degrader-1 | Others | |
PROTAC RAR Degrader-1, an RAR degrader, consists of a cIAP1 ligand binding group, a linker, and an RAR ligand binding group. It achieves maximal RAR degradation at a concentration of 30 μM in HT1080 cells. Degradation in... | |||
T62698 | MIDH1-IN-1 | ||
mIDH1-IN-1 (compound 43) is a potent and selective inhibitor of mIDH1 (isocitrate dehydrogenase 1 mutant) (IC50: 961.5 nM). mIDH1-IN-1 effectively inhibits the production of 2-HG (2-hydroxyglutarate) in HT1080 cells (EC5... | |||
T69618 | XR3054 | ||
XR3054 is a novel inhibitor of farnesyl protein transferase (FPTase). XR3054 inhibited the proliferation of the prostatic cancer cell lines LnCAP and PC3 and the colon carcinoma SW480 and HT1080 (IC50 values of 12.4, 12.... | |||
T78758 | IHMT-IDH1-053 | Isocitrate Dehydrogenase (IDH) | |
IHMT-IDH1-053 (compound 16) is an irreversible inhibitor exhibiting high selectivity for the IDH1 R132H mutant, achieving an IC50 of 4.7 nM. It preferentially targets IDH1 mutants over wild-type IDH1 and IDH2, both wild-... |