Search Result

Search Results for " hmgb1 "

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T82189	HMGB1-IN-2
	HMGB1-IN-2 (compound 15) is a selective inhibitor of the highly conserved nuclear protein HMGB1, demonstrating no inhibitory effect at an IC50 of 20.2 μM in RAW264.7 cells. At a concentration of 30 μM, HMGB1-IN-2 reduces...
T78056	HMGB1-IN-1
	HMGB1-IN-1 (compound 6) exhibits potent inhibition of NO production in RAW264.7 cells, with an IC50 of 15.9 ± 0.6 μM, and effectively disrupts the HMGB1/NF-κB/NLRP3 signaling pathway. This compound demonstrates promising...
T4074	GSK-872	GSK872,GSK'872,GSK2399872A	RIP kinase
	GSK-872 (GSK2399872A) is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity (IC50: 1.8 nM) and inhibits kinase activity (IC50: 1.3 nM).		RIP kinase
T24167	Inflachromene	ICM	Others
	Inflachromene (ICM) is an inhibitor of HMGB1 and HMGB expression with anti-inflammatory activity.Inflachromene reduces seizure severity in a mouse model of epilepsy by inhibiting HMGB1 translocation, inhibits endothelial...		Others
T66703	Fmoc-D-Cha-OH		Apoptosis
	Fmoc-D-Cha-OH (FDCO) is an apoptotic DNase γ inhibitor that inhibits the release of HMGB1.		Apoptosis
T9948	NecroX-7	LC-280126,LC28-0126,LC28 0126	NADPH-oxidase
	NecroX-7 (LC-280126) is a potent free radical scavenger and a HMGB1 (high-mobility group box 1) inhibitor. NecroX-7 can be used as an antidote to acetaminophen toxicity. NecroX-7 exerts a protective effect by preventing ...		NADPH-oxidase
T31411	DHA-37	DHA 37
	DHA-37 is an inducer of autophagic cell death through upregulation of HMGB1 in A549 cells.
T63660	Anti-inflammatory agent 19
	Anti-inflammatory agent 19 inhibits NO (IC50: 36.00 μM). anti-inflammatory agent 19 exhibits an inhibitory effect on HMGB1-induced late inflammatory responses. anti-inflammatory agent 19 can be used to study late inflamm...
T63473	Anti-inflammatory agent 18
	Anti-inflammatory agent 18 inhibits NO activity (IC50: 15.94 μM) and has an inhibitory effect on the late inflammatory response induced by HMGB1 and can be used to study late inflammatory diseases such as coronavirus dis...

Compounds

Synonym: GSK872,GSK'872,GSK2399872A

Synonym: LC-280126,LC28-0126,LC28 0126

Target: NADPH-oxidase

Anti-inflammatory agent 19

T63660

Synonym:

Target:

Anti-inflammatory agent 18

T63473

Synonym:

Target:

Cat No.	Product Name	Synonyms	Targets
T2741	Glycyrrhizic acid	Glycyrrhizin	Virus Protease , Dehydrogenase , MAO
	Glycyrrhizic acid (Glycyrrhizin) is a triterpenoid saponinl with anti-tumor and anti-diabetic activities.		Virus Protease , Dehydrogenase , MAO
TN6774	Emodin 6-O-β-D-glucoside	Glucoemodin	Others
	Emodin 6-O-β-D-glucoside (Glucoemodin) can protect barrier integrity and inhibit HMGB1-mediated inflammatory responses, which suggests a potential use as a therapy for sepsis or septic shock. Emodin 6-O-beta-D-glucoside ...		Others
T6S0721	Orientin	Lutexin,Luteolin-8-glucoside	Others
	1. Orientin (Luteolin-8-glucoside) may be regarded as a candidate therapeutic agent for treatment of vascular inflammatory diseases via inhibition of the HMGB1 signaling pathway. 2. Orientin protects vascular barrier int...		Others
T5S1632	Barlerin	8-O-Acetylshanzhiside methyl ester,ND01	VEGFR , TNF , NF-κB , Akt , Caspase
	Barlerin (8-O-Acetylshanzhiside methyl ester) has potential against cerebral ischemic injury, and its protective effect on oxygen-glucose deprivation-induced injury might be due to the suppression of intracellular Ca2+ e...		VEGFR , TNF , NF-κB , Akt , Caspase

Natural Products

Glycyrrhizic acid

T2741

Synonym: Glycyrrhizin

Target: Virus Protease, Dehydrogenase, MAO

Emodin 6-O-β-D-glucoside

Synonym: Lutexin,Luteolin-8-glucoside

Target: Others

Barlerin

T5S1632

Synonym: 8-O-Acetylshanzhiside methyl ester,ND01

Target: VEGFR, TNF, NF-κB, Akt, Caspase

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-02590	HMGB1 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	HMGB1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 53.3 kDa and the accession number is P63158.
TMPJ-00095	HMGB1 Protein, Human, Recombinant (Truncated)	Human	E. coli
	HMGB1 Protein, Human, Recombinant (Truncated) is expressed in E. coli expression system. The predicted molecular weight is 13 KDa and the accession number is P09429.
TMPY-01848	HMGB1 Protein, Human, Recombinant (aa 1-215, His)	Human	HEK293 Cells
	HMGB1 Protein, Human, Recombinant (aa 1-215, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.3 kDa and the accession number is A0A024RDR0.
TMPK-00104	HMGB1 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated	Human	HEK293 Cells
	High-mobility group box 1 (HMGB1) is a ubiquitous nuclear protein that promotes inflammation when released extracellularly after cellular activation, stress, damage or death. HMGB1 operates as one of the most intriguing ...
TMPJ-00094	HMGB1 Protein, Human, Recombinant (N-teminal)	Human	E. coli
	HMGB1 Protein, Human, Recombinant (N-teminal) is expressed in E. coli expression system. The predicted molecular weight is 14 KDa and the accession number is P09429.
TMPH-02707	HMGB1 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	HMGB1 Protein, Mouse, Recombinant (His) is expressed in E. coli.
TMPY-00822	HMGB1 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	HMGB1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 51.5 kDa and the accession number is A0A024RDR0.
TMPH-03313	HMGB1 Protein, Rat, Recombinant (His)	Rat	E. coli
	HMGB1 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 30.8 kDa and the accession number is P63159.
TMPY-03427	HMGB1 Protein, Human, Recombinant (aa 57-158, His)	Human	E. coli
	HMGB1 Protein, Human, Recombinant (aa 57-158, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 13.6 kDa and the accession number is P09429.