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Search Result

Search Results for " gaba-at "

37

Compounds

2

Natural Products

2

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T62185 GABA-AT-IN-1
GABA-AT-IN-1 (Compound 6) is an inhibitor of γ-aminobutyric acid transaminase (GABA-AT) that crosses the blood-brain barrier.
T14571 Bifenazate GABA Receptor
Bifenazate is a positive allosteric modulator of GABA receptor. Bifenazate is an acaricide that controls 100% of mites at a concentration of 25 ppm.
T2067 NS11394 NS 11394 GABA Receptor
NS11394 is a effective and subtype-selective GABA(A) receptor-positive modulator; possesses a functional efficacy selectivity profile of α(5) > α(3) > α(2) > α(1) at GABA(A) alpha subunit-containing receptors.
T4993 Afloqualone HQ-495 GABA Receptor
Afloqualone (HQ-495) is a agonist of GABA Receptor . Target: GABA Receptor in vitro: Afloqualone is a quinazolinone family GABAergic drug. It has sedative and muscle-relaxant effects, resulting from its agonist activity ...
T10618 Broflanilide GABA Receptor
Broflanilide is metabolized to desmethyl-broflanilide, which is a potent antagonist at the insect resistant-to-dieldrin GABA receptor and inhibits S. litura RDL GABAR (IC50: 1.3 nM).
T1065 Baclofen Lioresal GABA Receptor
Baclofen (Lioresal) is a synthetic chlorophenyl-butanoic acid derivative used to treat spasms due to spinal cord damage and multiple sclerosis, muscle-relaxing Baclofen acts as a gamma-aminobutyric acid (GABA) agonist sp...
T8639 Phenibut (hydrochloride) 3-Amino-4-phenylbutyric acid hydrochloride GABA Receptor
Phenibut hydrochloride (3-Amino-4-phenylbutyric acid hydrochloride) is a GABA mimetic that acts as an agonist at GABAB receptors, blocks α2δ subunit-containing voltage-gated calcium channels, stimulates dopamine receptor...
T37190 L-Allylglycine Dehydrogenase , GABA Receptor
L-Allylglycine is an amino acid derivative that reduces glutamate decarboxylase (GAD) activity by 60% when administered at a dose of 39.8 μmol/g per hour ex vivo in mouse brain preparations. L-Allylglycine (1.2 mmol/kg, ...
T8630 Baclofen hydrochloride 4-amino-3-(4-chlorophenyl)butanoic acid hydron chloride GABA Receptor
Baclofen hydrochloride (4-amino-3-(4-chlorophenyl)butanoic acid hydron chloride) is a GAMMA-AMINOBUTYRIC ACID derivative that is a specific GABA-B RECEPTORS agonist. It is used in the treatment of MUSCLE SPASTICITY, espe...
T11277 FG 7142 ZK 39106,LSU-65 GABA Receptor
FG 7142 (LSU-65) also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50= 137 nM). FG 7142 can increase tyrosine hydroxylation and cause upregulation of β-adrenoceptors in mouse cereb...
T36520 COR659 Cannabinoid Receptor , GABA Receptor
COR659 is a GABAB positive allosteric modulator (PAM) . COR659 suppresses alcohol and chocolate self-administration in rats[1]. COR659 apparently exerts its effects via a composite mechanism, including positive allosteri...
T13690 Etifoxine hydrochloride HOE 36-801 hydrochloride GABA Receptor
Etifoxine hydrochloride (HOE 36-801 hydrochloride) is an anxiolytic and anticonvulsant drug. Unlike benzodiazepines, Etifoxine hydrochloride appears to produce its anxiolytic effects by binding to β2 and β3 subunits of t...
T38192 Unifiram Others
Unifiram is a nootropic agent.1It increases acetylcholine (ACh) release in the rat cerebral cortexin vivoand induces a long-lasting increase in the amplitude of field excitatory postsynaptic potentials (fEPSPs) in the ra...
T29058 UMB68 sodium UMB-68 sodium,UMB68,UMB-68,UMB 68
UMB-68 is a GHB receptor ligand with no affinity (IC(50) >100 microM) at GABA(A) or GABA(B) receptors.
T71524 Famiraprinium
Famiraprinium is a competitive antagonist at the GABA receptor site.
T68214 Famiraprinium chloride
Famiraprinium chloride is a competitive antagonist at the GABA receptor site.
T82356 GABA-IN-1
GABA-IN-1 (Compound 6), a GABA inhibitor, exhibits larvicidal and insecticidal properties, achieving a mortality rate of 93% at a concentration of 50 mg/L [1].
T82355 GABA-IN-2
GABA-IN-2 (Compound 5), a GABA inhibitor, exhibits both larvicidal and insecticidal properties, achieving an 87% mortality rate at a concentration of 50 mg/L [1].
T17306 (R)-Baclofen hydrochloride Arbaclofen hydrochloride GABA Receptor
Arbaclofen hydrochloride, a Gamma-Aminobutyric Acid derivative, is a specific agonist of GABA-B receptors, it is used to treat spasticity, especially that due to spinal cord damage. It acts at spinal and supraspinal site...
T26366L Prasterone sulfate sodium hydrate Sodium dehydroepiandrosterone sulfate,Prasterone sulfate sodium salt dihydrate,5-Androsten-3β-ol-17-one sulfate sodium salt dihydrate
Prasterone is an endogenous steroid hormone. Prasterone acts as an agonist at ERβ, NMDA, and σ1 receptors, a partial agonist at ERα and AR, and antagonist at GABA-A receptors. It displays a variety of biologocial activit...
T79399 E2730 GABA Receptor
E2730 is a selective and noncompetitive inhibitor of the gamma-aminobutyric acid (GABA) transporter 1 (GAT1) that exhibits oral availability as well as antiepileptic properties. Its inhibition of GAT1 is dependent on the...
T29227 ZK-91296 ZK 91296,ZK91296
ZK-91296 is a GABA receptor agonist. ZK 91296 can reduce anxiety in animals at doses well below those causing sedation. ZK 91296 may possess pharmacological selectivity for a particular type of BZ receptor interaction, p...
T73608 Muscimol hydrochloride
Muscimol hydrochloride (Agarin; Agarine) is an isoxazole compound known for its psychoactive properties, acting as a potent selective agonist of GABA A receptors (EC 50 =0.2 μM), a partial agonist of GABA C receptors, an...
T28183 NNC052090 NNC-052090,NNC-05-2090,NNC05-2090,NNC 052090,NNC 05-2090
NNC052090 is a GABA uptake inhibitor that displays moderate selectivity for BGT-1 transporters with Ki values are 1.4, 15, 19 and 41 μM for hBGT-1, hGAT-3, hGAT-1 and hGAT-2 respectively. NNC052090 also displays affinity...
T37699 Org 24598
Potent and selective inhibitor of the glial glycine transporter GlyT1b (IC50 = 6.9 nM). Displays negligible activity at GlyT-2, adrenoreceptors, dopamine, 5HT receptors and noradrenaline, dopamine, 5HT and GABA transport...
T37725 Tetrahydrodeoxycorticosterone 21-Hydroxypregnanolone,Tetrahydro-11-deoxycorticosterone GABA Receptor
Tetrahydrodeoxycorticosterone(Tetrahydro-11-deoxycorticosterone) is a potent GABAA receptor orthosteric modulator (PAM) with neuroprotective activity that selectively inhibits neurosteroid-mediated enhancement of GABA-in...
T69104 SAX-187 hydrochloride
SAX-187 hydrochloride is a potent and selective 5-HT6 receptor agonist. SAX-187 hydrochloride possesses high affinity binding (2.2 and 4.8 nM, respectively) at the human 5-HT6 receptor and profile as full receptor agonis...
T37388 Afizagabar
Afizagabar (S44819) is a first-in-class, competitive, and selective antagonist at the GABA-binding site of the α5-GABAAR, with an IC50 of 585 nM for α5β2γ2 and a Ki of 66 nM for α5β3γ2. Afizagabar enhances hippocampal sy...
T60842 GABAA receptor agonist 1
GABAA receptor agonist 1 (compound 3e) is a potent agonist of GABAA receptor that binds at the GABA binding site of GABAA receptor to produce GABAergic effects. GABAA receptor agonist 1 has anti-depression activities in ...
T37319 5β-Dihydroprogesterone
5β-Dihydroprogesterone (5β-DHP) is a progesterone receptor agonist and metabolite of progesterone .1,2It is formed from progesterone by 5β-reductase.25β-DHP inhibits spontaneous contractions in isolated rat uterus when u...
T35746 Milbemycin A3
Milbemycin A3 is a member of a complex family of macrocyclic lactones that contain a characteristic spiroketal group produced from the fermentation of soil bacterium S. hygroscopicus subsp. aureolacrimosus. As a compound...
T71206 Tiagabine-d6 hydrochloride
Tiagabine-d6 is intended for use as an internal standard for the quantification of tiagabine by GC- or LC-MS. Tiagabine is an inhibitor of GABA transporter 1. It inhibits seizures induced by DMCM in mice. Tiagabine reduc...
T82357 GABA receptor Antagonist 1 GABA Receptor
GABA receptor Antagonist 1 (compound 7w) effectively inhibits the Px RDL1 GABAR at an IC50 of 7.08 nmol/L and demonstrates insecticidal efficacy against P. xylostella, S. frugiperda, S. exigua, and S. litura with respect...
T70063 GYKI 52466 HCl
GYKI 52466 is an allosteric AMPA receptor antagonist. It selectively inhibits AMPA-induced inward currents (IC50 = 7.5 µM) over NMDA- or GABA-induced inward currents in primary rat hippocampal neurons at 50 µM but also i...
T37194 5α-Androst-16-en-3α-ol
5α-Androst-16-en-3α-ol is a steroid pheromone that has been found in boar testes and human male axillary sweat and has diverse biological activities.1,2It enhances GABA-activated currents in primary mouse cerebellar gran...
T36521 Alaproclate (hydrochloride)
Alaproclate is a selective serotonin reuptake inhibitor (SSRI).1,2 It inhibits depletion of serotonin (5-HT) induced by 4-methyl-α-ethyl-m-tyramine in rat cerebral cortex, hippocampus, hypothalamus, and striatum (EC50s =...
T65396 Piperazine 2HCl
Piperazine (2HCl) is gamma-aminobutyric acid (GABA) agonists and its major effects appear to be on the central nervous system. Piperazine was the anthelmintic with the greatest number of reports of toxicoses and suspecte...

Compounds

GABA-AT-IN-1
T62185
Synonym:
Target:
Bifenazate
T14571
Synonym:
Target: GABA Receptor
NS11394
T2067
Synonym: NS 11394
Target: GABA Receptor
Afloqualone
T4993
Synonym: HQ-495
Target: GABA Receptor
Broflanilide
T10618
Synonym:
Target: GABA Receptor
Baclofen
T1065
Synonym: Lioresal
Target: GABA Receptor
Phenibut (hydrochloride)
T8639
Synonym: 3-Amino-4-phenylbutyric acid hydrochloride
Target: GABA Receptor
L-Allylglycine
T37190
Synonym:
Target: Dehydrogenase, GABA Receptor
Baclofen hydrochloride
T8630
Synonym: 4-amino-3-(4-chlorophenyl)butanoic acid hydron chloride
Target: GABA Receptor
FG 7142
T11277
Synonym: ZK 39106,LSU-65
Target: GABA Receptor
COR659
T36520
Synonym:
Target: Cannabinoid Receptor, GABA Receptor
Etifoxine hydrochloride
T13690
Synonym: HOE 36-801 hydrochloride
Target: GABA Receptor
Unifiram
T38192
Synonym:
Target: Others
UMB68 sodium
T29058
Synonym: UMB-68 sodium,UMB68,UMB-68,UMB 68
Target:
Famiraprinium
T71524
Synonym:
Target:
Famiraprinium chloride
T68214
Synonym:
Target:
GABA-IN-1
T82356
Synonym:
Target:
GABA-IN-2
T82355
Synonym:
Target:
(R)-Baclofen hydrochloride
T17306
Synonym: Arbaclofen hydrochloride
Target: GABA Receptor
Prasterone sulfate sodium hydrate
T26366L
Synonym: Sodium dehydroepiandrosterone sulfate,Prasterone sulfate sodium salt dihydrate,5-Androsten-3β-ol-17-one sulfate sodium salt dihydrate
Target:
E2730
T79399
Synonym:
Target: GABA Receptor
ZK-91296
T29227
Synonym: ZK 91296,ZK91296
Target:
Muscimol hydrochloride
T73608
Synonym:
Target:
NNC052090
T28183
Synonym: NNC-052090,NNC-05-2090,NNC05-2090,NNC 052090,NNC 05-2090
Target:
Org 24598
T37699
Synonym:
Target:
Tetrahydrodeoxycorticosterone
T37725
Synonym: 21-Hydroxypregnanolone,Tetrahydro-11-deoxycorticosterone
Target: GABA Receptor
SAX-187 hydrochloride
T69104
Synonym:
Target:
Afizagabar
T37388
Synonym:
Target:
GABAA receptor agonist 1
T60842
Synonym:
Target:
5β-Dihydroprogesterone
T37319
Synonym:
Target:
Milbemycin A3
T35746
Synonym:
Target:
Tiagabine-d6 hydrochloride
T71206
Synonym:
Target:
GABA receptor Antagonist 1
T82357
Synonym:
Target: GABA Receptor
GYKI 52466 HCl
T70063
Synonym:
Target:
5α-Androst-16-en-3α-ol
T37194
Synonym:
Target:
Alaproclate (hydrochloride)
T36521
Synonym:
Target:
Piperazine 2HCl
T65396
Synonym:
Target:
Cat No. Product Name Synonyms Targets
T3741 (-)-borneol L-Borneol GABA Receptor
(-)-borneol (L-Borneol) has a highly efficacious positive modulating action at GABA receptor with an EC50 of 237 μM.
T4881 Phosphorylethanolamine O-Phosphorylethanolamine Others , Endogenous Metabolite
Phosphorylethanolamine (O-Phosphorylethanolamine) is a phosphomonoester metabolite of the phospholipid metabolism. Phosphorylethanolamine is a precursor of phospholipid synthesis and a product of phospholipid breakdown. ...

Natural Products

(-)-borneol
T3741
Synonym: L-Borneol
Target: GABA Receptor
Phosphorylethanolamine
T4881
Synonym: O-Phosphorylethanolamine
Target: Others, Endogenous Metabolite

Recombinant Proteins

Species：
Human (2)
Expression System：
E. coli (2)
Tag：
N-10xHis-SUMO, C-Myc (1)
N-6xHis-SUMO (1)
Cat No. Product Name Species Expression System
TMPH-00857 ABAT Protein, Human, Recombinant (His & Myc & SUMO) Human E. coli
Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine. ABAT Protein, Hu...
TMPH-01248 ADAR Protein, Human, Recombinant (His & SUMO) Human E. coli
Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translatio...
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