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Etifoxine hydrochloride

Catalog No. T13690 CAS 56776-32-0

Synonyms: HOE 36-801 hydrochloride

Etifoxine hydrochloride (HOE 36-801 hydrochloride) is an anxiolytic and anticonvulsant drug. Unlike benzodiazepines, Etifoxine hydrochloride appears to produce its anxiolytic effects by binding to β2 and β3 subunits of the GABAA receptor complex, and so is acting at a different target site to benzodiazepines, although the physiological effect that is produced is similar to that of benzodiazepines.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Etifoxine hydrochloride Chemical Structure

Etifoxine hydrochloride, CAS 56776-32-0

Pack Size	Availability	Price/USD
2 mg	In stock	$ 34.00
5 mg	In stock	$ 55.00
10 mg	In stock	$ 80.00
25 mg	In stock	$ 153.00
50 mg	In stock	$ 278.00
100 mg	In stock	$ 493.00
1 mL * 10 mM (in DMSO)	In stock	$ 61.00

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Purity: 99.25%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	HOE 36-801 hydrochloride
Molecular Weight	337.24
Formula	C17H18Cl2N2O
CAS No.	56776-32-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (148.26 mM), Sonification is recommended.

References and Literature

1. Verleye M, Dumas S, Heulard I, et al. Differential effects of etifoxine on anxiety-like behaviour and convulsions in BALB/cByJ and C57BL/6J mice: any relation to overexpression of central GABAA receptor beta2 subunits? Eur Neuropsychopharmacol. 2011 Jun;21(6):457-70. 2. Bourin M, Hascot M. Implication of 5-HT2 receptor subtypes in the mechanism of action of the GABAergic compound etifoxine in the four-plate test in Swiss mice. Behav Brain Res. 2010 Apr 2;208(2):352-8. 3. Gee KW, Tran MB, Hogenkamp DJ, et al. Limiting activity at beta1-subunit-containing GABAA receptor subtypes reduces ataxia. J Pharmacol Exp Ther. 2010 Mar;332(3):1040-53. 4. Aouad M, Charlet A, Rodeau JL, et al. Reduction and prevention of vincristine-induced neuropathic pain symptoms by the non-benzodiazepine anxiolytic etifoxine are mediated by 3alpha-reduced neurosteroids. Pain. 2009 Dec 15;147(1-3):54-9. 5. Girard C, Liu S, Cadepond F, et al. Etifoxine improves peripheral nerve regeneration and functional recovery. Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20505-10.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Anti-Neurodegenerative Disease Compound Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Neurotransmitter Receptor Compound Library Neuronal Signaling Compound Library Preclinical Compound Library Bioactive Compounds Library Max Anti-Cancer Compound Library ReFRAME Related Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Etifoxine hydrochloride 56776-32-0 Membrane transporter/Ion channel Neuroscience GABA Receptor TBPS Anxiolytic γ-Aminobutyric acid Receptor disorder HOE 36-801 Hydrochloride HOE 36-801 inhibit adjustment Etifoxine Inhibitor Gamma-aminobutyric acid Receptor HOE 36-801 hydrochloride Etifoxine Hydrochloride inhibitor

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