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Prasterone sulfate sodium hydrate

Catalog No. T26366L CAS 78590-17-7

Synonyms: Sodium dehydroepiandrosterone sulfate, Prasterone sulfate sodium salt dihydrate, 5-Androsten-3β-ol-17-one sulfate sodium salt dihydrate

Prasterone is an endogenous steroid hormone. Prasterone acts as an agonist at ERβ, NMDA, and σ1 receptors, a partial agonist at ERα and AR, and antagonist at GABA-A receptors. It displays a variety of biologocial activities, including enhancing working memory and cognition, inhibiting proliferation and migration of cervical cancer cells, increasing expression of various glutamate transporters to suppress seizures, and minimizing lipid peroxidation, gastric acid secretion and ulcer formation.

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Prasterone sulfate sodium hydrate Chemical Structure

Prasterone sulfate sodium hydrate, CAS 78590-17-7

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Biological Description

Chemical Properties

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Description

Synonyms	Sodium dehydroepiandrosterone sulfate, Prasterone sulfate sodium salt dihydrate, 5-Androsten-3β-ol-17-one sulfate sodium salt dihydrate
Molecular Weight	427.51
Formula	C19H32NaO7S
CAS No.	78590-17-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Labrie F, Archer D, Bouchard C, Fortier M, Cusan L, Gomez JL, Girard G, Baron M, Ayotte N, Moreau M, Dubé R, Côté I, Labrie C, Lavoie L, Gilbert L, Martel C, Balser J. Lack of influence of dyspareunia on the beneficial effect of intravaginal prasterone (dehydroepiandrosterone, DHEA) on sexual dysfunction in postmenopausal women. J Sex Med. 2014 Jul;11(7):1766-85. doi: 10.1111/jsm.12517. Epub 2014 Apr 28. PubMed PMID: 24774442. 2. Labrie F, Martel C, Bérubé R, Côté I, Labrie C, Cusan L, Gomez JL. Intravaginal prasterone (DHEA) provides local action without clinically significant changes in serum concentrations of estrogens or androgens. J Steroid Biochem Mol Biol. 2013 Nov;138:359-67. doi: 10.1016/j.jsbmb.2013.08.002. Epub 2013 Aug 14. PubMed PMID: 23954500. 3. Labrie F, Archer DF, Bouchard C, Girard G, Ayotte N, Gallagher JC, Cusan L, Baron M, Blouin F, Waldbaum AS, Koltun W, Portman DJ, Côté I, Lavoie L, Beauregard A, Labrie C, Martel C, Balser J, Moyneur É; Members of the VVA Prasterone Group. Prasterone has parallel beneficial effects on the main symptoms of vulvovaginal atrophy: 52-week open-label study. Maturitas. 2015 May;81(1):46-56. doi: 10.1016/j.maturitas.2015.02.005. Epub 2015 Feb 16. PubMed PMID: 25771041. 4. Archer DF, Labrie F, Bouchard C, Portman DJ, Koltun W, Cusan L, Labrie C, Côté I, Lavoie L, Martel C, Balser J; VVA Prasterone Group. Treatment of pain at sexual activity (dyspareunia) with intravaginal dehydroepiandrosterone (prasterone). Menopause. 2015 Sep;22(9):950-63. doi: 10.1097/GME.0000000000000428. PubMed PMID: 25734980.

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Keywords

Prasterone sulfate sodium hydrate 78590-17-7 Sodium dehydroepiandrosterone sulfate 5-Androsten-3b-ol-17-one sulfate sodium Dihydrate 5-Androsten-3β-ol-17-one sulfate sodium Dihydrate Prasterone sulfate sodium salt dihydrate 5-Androsten-3beta-ol-17-one sulfate sodium 5-Androsten-3β-ol-17-one sulfate sodium salt dihydrate 5-Androsten-3b-ol-17-one sulfate sodium 5-Androsten-3β-ol-17-one sulfate sodium Sodium dehydroepiandrosterone Sulfate Prasterone sulfate sodium Hydrate Prasterone sulfate sodium Prasterone sulfate sodium Dihydrate inhibitor inhibit

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