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Broflanilide

Name: Broflanilide
Brand: TargetMol
SKU: T10618
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10618Cas No. 1207727-04-5

Broflanilide is metabolized to desmethyl-broflanilide, which is a potent antagonist at the insect resistant-to-dieldrin GABA receptor and inhibits S. litura RDL GABAR with IC50 of 1.3 nM.

Broflanilide

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Purity: 99.82%

Catalog No. T10618Cas No. 1207727-04-5

Broflanilide is metabolized to desmethyl-broflanilide, which is a potent antagonist at the insect resistant-to-dieldrin GABA receptor and inhibits S. litura RDL GABAR with IC50 of 1.3 nM.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$48	In Stock	In Stock
2 mg	$68	In Stock	In Stock
5 mg	$113	In Stock	In Stock
10 mg	$189	In Stock	In Stock
25 mg	$376	In Stock	In Stock
50 mg	$619	In Stock	In Stock
100 mg	$879	-	In Stock
1 mL x 10 mM (in DMSO)	$133	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.82%

Resource Download

COA HNMR FNMR LCMS

Product Introduction

Bioactivity

Description	Broflanilide is metabolized to desmethyl-broflanilide, which is a potent antagonist at the insect resistant-to-dieldrin GABA receptor and inhibits S. litura RDL GABAR with IC50 of 1.3 nM.
Targets&IC50	GlyR:3 μM (human), GlyR α1 (A288Gβ):0.706 μM, GlyR α1 (A288G):0.149 μM, GABA receptor:1.3 nM (S. litura RD cellsL), GABAA α1β3γ2:3 μM (mammalian)
In vitro	Broflanilide, an insecticide metabolized to desmethyl-broflanilide, exhibits weak activity against human GABAA α1β2γ2, mammalian GABAA α1β3γ2, and human glycine receptor (GlyR) α1β with IC50s >3 μM, and less potent inhibition of GlyR α1-A288Gβ and GlyR α1-A288G with IC50s of 0.706 μM and 0.149 μM, respectively.

Chemical Properties

Molecular Weight	663.29
Formula	C₂₅H₁₄BrF₁₁N₂O₂
Cas No.	1207727-04-5
Smiles	CN(C(=O)c1ccccc1)c1cccc(C(=O)Nc2c(Br)cc(cc2C(F)(F)F)C(F)(C(F)(F)F)C(F)(F)F)c1F
Relative Density.	1.625 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 262.5 mg/mL (395.75 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (4.98 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5076 mL	7.5382 mL	15.0764 mL	75.3818 mL
5 mM	0.3015 mL	1.5076 mL	3.0153 mL	15.0764 mL
10 mM	0.1508 mL	0.7538 mL	1.5076 mL	7.5382 mL
20 mM	0.0754 mL	0.3769 mL	0.7538 mL	3.7691 mL
50 mM	0.0302 mL	0.1508 mL	0.3015 mL	1.5076 mL
100 mM	0.0151 mL	0.0754 mL	0.1508 mL	0.7538 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc