fkbp — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T18610	PROTAC FKBP Degrader-3		Others
	PROTAC FKBP Degrader-3 is a PROTAC that comprises a FKBP ligand binding group, a linker and an VHL binding group. PROTAC FKBP Degrader-3 is a potent FKBP degrader[1].		Others
T14298	Rimiducid		Apoptosis , Others , Fatty Acid Synthase
	Rimiducid is a lipid-permeable tacrolimus analogue, homodimerizing an analogue of human protein fkbp12 and binding to wild-type fkbp12 with 1000-fold lower affinity. Rimiducid is a dimerizer agent that acts by cross-link...		Apoptosis , Others , Fatty Acid Synthase
T13884	Shield-1		Others
	Shield-1 is a specific, high-affinity and cell-permeant ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to mutated FKBP (mtFKBP), allowing conditional expression of mtFKBP-fused protein...		Others
T14299	AP20187	B/B Homodimerizer	Others
	AP20187 (B/B Homodimerizer) is a cell-permeable compound employed to dimerize FK506-binding protein (FKBP) fusion proteins, thereby initiating biological signaling cascades, gene expression, or disrupting protein-protein...		Others
T1784	Everolimus	RAD001,SDZ-RAD	Apoptosis , Others , mTOR , Autophagy
	Everolimus (SDZ-RAD) is a potent mTOR inhibitor that binds to FKBP-12. It is used alone or in combination with calcineurin inhibitors.		Apoptosis , Others , mTOR , Autophagy
T11451	GPI-1046		Others , HIV Protease
	GPI-1046 is an immunophilin ligand without antibiotic action and attenuates ethanol intake in part through the upregulation of glutamate transporter 1 (GLT1) in PFC and NAc-core.		Others , HIV Protease
T2144	Tacrolimus	Fujimycin,FK506,FR900506	Phosphatase , Others , Antibacterial , Antibiotic , mTOR , Autophagy
	Tacrolimus (Fujimycin) can bind FKBP12 to form a high-affinity complex (Ki: 0.2 nM) which inhibits the activity of the calcium/calmodulin-dependent protein phosphatase.
T2567	Etonogestrel	3-Oxodesogestrel,3-keto-Desogestrel,Nexplanon,Implanon	Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Progesterone Receptor , Endogenous Metabolite
	Etonogestrel (Implanon) is a steroidal progestin used as hormonal contraceptives.
T2481	Ascomycin	FK520,Immunomycin,FR-900520	Phosphatase , Others , Antibiotic , Parasite , Antifungal
	Ascomycin (Immunomycin)(Immunomycin, FR-900520, FK520) is an ethyl analog of tacrolimus (FK506) with strong immunosuppressant properties.		Phosphatase , Others , Antibiotic , Parasite , Antifungal
T1537	Rapamycin	Sirolimus,AY 22989,NSC-2260804	Others , Endogenous Metabolite , Antibiotic , mTOR , Autophagy , Antifungal
	Rapamycin (AY 22989) is a natural product of macrolides, an mTOR inhibitor with specificity (HEK293 cells: IC50=0.1 nM). Rapamycin has immunosuppressive activity and induces autophagy.
T13694	FKBP12 PROTAC RC32	RC32	Others
	FKBP12 PROTAC RC32 contains conjugation of Rapamycin and a ligand for an E3 ubiquitin ligase.FKBP12 PROTAC RC32 (RC32) is a potent FKBP12 degrader based on PROTAC technology.		Others
T20879	Tacrolimus monohydrate	FK-506,FR 900506,Prograf,FR900506,Tacrolimus hydrate,LCP-Tacro,FK 506	Phosphatase , Others , Antibacterial , Antibiotic , Autophagy
	Tacrolimus monohydrate (LCP-Tacro) is a macrolide from the culture broth of a strain of Streptomyces tsukubaensis, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, whi...
T11292	FKBP12 PROTAC dTAG-7	dTAG-7	Epigenetic Reader Domain
	FKBP12 PROTAC dTAG-7 (dTAG-7) is a heterobifunctional compound that selectively degrades the BET bromodomain transcriptional co-activator BRD4 by connecting BET bromodomains to the E3 ubiquitin ligase CRBN. Additionally,...		Epigenetic Reader Domain
T11291	FKBP12 PROTAC dTAG-13	dTAG-13	Epigenetic Reader Domain
	FKBP12 PROTAC dTAG-13 (dTAG-13) is a degrader of FKBP12F36V with expression of FKBP12F36V in-frame with a protein of interest. FKBP12 PROTAC dTAG-13 (dTAG-13) also is a selective degrader of BET bromodomain transcription...		Epigenetic Reader Domain
T71840	FKBP12-IN-Q2
	FKBP12-IN-Q2 is an inhibitor of FKBP12.
T79184	FKBP51F67V-selective antagonist Ligand2		FKBP
	FKBP51F67V-selective antagonist Ligand2 (example 3-3), a potent ligand, selectively binds to the FKBP51 F67V variant, with no affinity for wild-type FKBP51 or FKBP52 [1]. It effectively reverses the anxiogenic phenotype ...		FKBP
T18597	DFKBP-1		Others
	dFKBP-1 is a potent and PROTAC-based FKBP12 degrader. dFKBP-1 incorporates the ligand SLF of FKBP12, the Thalidomide based cereblon ligand and a linker[1].		Others
T6033	Zotarolimus	ABT-578,A 179578	mTOR
	Zotarolimus (ABT-578), an analogue of rapamycin, inhibits FKBP-12 (IC50= 2.8 nM).		mTOR
T2648	Pimecrolimus	SDZ-ASM 981,ASM 981	Others
	Pimecrolimus (SDZ-ASM 981), a calcineurin inhibitor immunosuppressant, binds to the receptor macrophilin-12 (FKBP-12) forming a complex that blocks the calcium-dependent signal transduction cascade mediated by calcineuri...		Others
T24788	Shield-2
	Shield-2 is a potent FKBP-derived destabilizing domain stabilizing ligand.