drg — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T27260	Emivirine	MKC442,MKC-442,MKC 442,DRG-0302,DRG 0302,DRG0302	HIV Protease
	Emivirine (MKC-442) is a potent and selective nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1.		HIV Protease
T7655	Fialuridine	DRG-0098,FIAU	DNA/RNA Synthesis
	Fialuridine (DRG-0098) is a DNA-directed DNA polymerase inhibitor potentially for the treatment of HBV infection with potent activity against hepatitis B virus in vitro and in vivo.		DNA/RNA Synthesis
T27790	Labradimil	RMP-7,ALK-01-040,Receptor-mediated permeabiliser-7,DRG0182,DRG 0182,DRG-0182
	Labradimil is a bradykinin B2 receptor agonist. Labradimil increases the permeability of human brain microvascular endothelial cell monolayers. Labradimil enhances delivery of hydrophilic chemotherapeutics and increases ...
T19689	Raluridine	FddClUrd,935U-83,FCU,DRG-0215,BW-935U-83
	Raluridine is a RNA-directed DNA polymerase inhibitor potentially for the treatment of HIV infection. 935U83 inhibited virus growth with an average 50% inhibitory concentration (IC50: 1.8 microM) corresponding IC50s were...
T6702L	Terbinafine lactate	DRG-0286,Terbinafine hydrochloride,Lamisil Krem,SF 86-327 hydrochloride,Lamisil,Lamisil AT
	Terbinafine, a synthetic allylamine antifungal, inhibits ergosterol synthesis by inhibiting squalene epoxidase, an enzyme that is part of the fungal cell membrane synthesis pathway.
T8538	ML382		Others
	ML382 is a potent and selective MrgX1 positive allosteric modulator(EC50 : 190 nM).		Others
T23498	UNC3230	UNC 3230	Others
	UNC3230 is a potent, selective and ATP-competitive PIP5K1C inhibitor with an IC50 of ~41 nM. UNC3230(UNC 3230) also inhibits PIP4K2C.		Others
T73469	SG2057	DRG16
	SG2057 (DRG16), a potent antitumor agent, is a pyrrolobenzodiazepine (PBD) dimer connected by a pentyldioxy linkage. This compound selectively binds to the minor groove of DNA, forming both interstrand and intrastrand cr...
T7416	WS-12		TRP/TRPV Channel
	WS-12 is a potent TRPM8 agonist that acts as a cooling agent (EC50 : 193 nM)		TRP/TRPV Channel
T2173	Veratridine		Sodium Channel
	Veratridine is a benzoate-cevane found in Veratrum and Schoenocaulon. It activates sodium channels to stay open longer than normal.		Sodium Channel
T4431	Olodanrigan	PD-126055,EMA401	RAAS
	Olodanrigan (EMA401), a highly selective AT2R antagonist, inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation, and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons. EMA...		RAAS
T67981	Copper histidine
	Copper histidine inhibited Ctr1-mediated cellular uptake of oxaliplatin in vitro without altering oxaliplatin accumulation of platinum or neurotoxicity in DRG tissues in vivo. Copper histidine is administered orally for ...
T26745	BAY 73-1449	BAY-73-1449,BAY73-1449	Others
	BAY-73-1449 is an antagonist of prostacyclin receptor.		Others
TN1087	Deoxypodophyllotoxin		Apoptosis , Microtubule Associated , Autophagy
	Deoxypodophyllotoxin shows cytotoxic , antineoplastic, antitumor, insecticidal, anti-angiogenic, vascular disrupting, insecticidal, antiviral, and anti-inflammatory activities.		Apoptosis , Microtubule Associated , Autophagy
T26376	11-deoxy-PGF2a	11-deoxyPGF2a,11-deoxy PGF2a
	11-deoxy-PGF2a, a selective activator of TREK-2 channels, stimulates DRG c-fiber nociceptor K2P currents and limits calcium influx.
T80448	ω-Conotoxin CVIF		Calcium Channel
	ω-Conotoxin CVIF is a selective inhibitor of Ca v 2.2 channels, demonstrating an IC50 value of 34.3 nM in isolated rat DRG neurons. Its blockade of Cav2.2 channels is weakly reversible [1].		Calcium Channel
T80455	ω-Conotoxin CVIB		Sodium Channel
	ω-Conotoxin CVIB is an antagonist of non-selective N- and P/Q-type voltage-gated calcium channels (VGCCs). It inhibits depolarization-activated whole-cell VGCC currents in dorsal root ganglion (DRG) neurons, exhibiting a...		Sodium Channel
T16135	MRS 1523		Others
	MRS 1523 can exert an antihyperalgesic effect through N-type Ca channel block and action potential inhibition in isolated rat dorsal root ganglion (DRG) neurons. MRS 1523 is an effective and selective adenosine A3 recept...		Others
T80421	CSD-CH2(1,8)-NH2		Opioid Receptor
	CSD-CH2(1,8)-NH2 is a selective and competitive kappa-opioid receptor (KOR) antagonist with a K i of 6.8 nM. It inhibits calcium mobilization in dorsal root ganglion (DRG) neurons and antagonizes the antinociceptive effe...		Opioid Receptor
T37219	N-Palmitoyl Glycine
	The acyl amides are a family of endogenous lipids that act as potent modulators of pain and inflammation. The best characterized members of this family are the arachidonoyl amides, which includes N-arachidonoyl ethanolam...