Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ML382 is a potent and selective MrgX1 positive allosteric modulator(EC50 : 190 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 30.00 | |
5 mg | In stock | $ 68.00 | |
10 mg | In stock | $ 113.00 | |
25 mg | In stock | $ 219.00 | |
50 mg | In stock | $ 397.00 | |
100 mg | In stock | $ 589.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 76.00 |
Description | ML382 is a potent and selective MrgX1 positive allosteric modulator(EC50 : 190 nM). |
Targets&IC50 | MrgX1:190 nM(EC50) |
In vivo | ML382 enhances the ability of BAM8-22 to inhibit high-voltage-activated Ca2+ channels and attenuate spinal nociceptive transmission, both BAM8-22 and ML382 effectively attenuated evoked, persistent, and spontaneous pain without causing obvious side effects.?Notably, ML382 by itself attenuated both evoked pain hypersensitivity and spontaneous pain in MrgprX1 mice after nerve injury without acquiring coadministration of an exogenous agonist[2] |
Molecular Weight | 360.43 |
Formula | C18H20N2O4S |
CAS No. | 1646499-97-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 32.5 mg/mL (90.17 mM)
You can also refer to dose conversion for different animals. More
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ML382 1646499-97-9 Others Inhibitor nociceptor pain injury DRG inhibit neurons nervous ML 382 ML-382 inhibitor