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WS-12

Catalog No. T7416 CAS 68489-09-8

WS-12 is a potent TRPM8 agonist that acts as a cooling agent (EC50 : 193 nM)

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WS-12, CAS 68489-09-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 34.00
2 mg	In stock	$ 48.00
5 mg	In stock	$ 77.00
10 mg	In stock	$ 101.00
25 mg	In stock	$ 172.00
50 mg	In stock	$ 223.00
100 mg	In stock	$ 290.00
500 mg	In stock	$ 713.00
1 mL * 10 mM (in DMSO)	In stock	$ 84.00

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Purity: 99.71%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	WS-12 is a potent TRPM8 agonist that acts as a cooling agent (EC50 : 193 nM)
Targets&IC50	TRPM8:39 nM (EC50)
In vitro	WS-12, had an EC(50) value about 2000 times lower than that of menthol and is, therefore, the highest-affinity TRPM8 ligand known to date.

Molecular Weight	289.41
Formula	C18H27NO2
CAS No.	68489-09-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 20 mg/mL (69.11 mM)

References and Literature

1. Beck B , Bidaux G , Bavencoffe A , et al. Prospects for prostate cancer imaging and therapy using high-affinity TRPM8 activators[J]. Cell Calcium, 2007, 41(3):285-294.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compounds Library Max NO PAINS Compound Library Food Additive Library Ion Channel Inhibitor Library Bioactive Compound Library Neuronal Signaling Compound Library Anti-Cancer Compound Library Human Metabolite Library

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TC-I 2014 AMTB hydrochloride TRPV4 agonist-1 free base HC-070 MK-2295 NGD-8243 Pyr6 ML329

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

WS-12 68489-09-8 Membrane transporter/Ion channel TRP/TRPV Channel HEK293T AVX 012 chronic neuropathic pain WS12 TRP Channel AR 15512 inhibit AVX012 AR15512 AVX-012 Inhibitor AR-15512 Transient receptor potential channels analgesic effect WS 12 cultured mouse DRG neurons inhibitor

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