dlbcl — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T10096L	Voruciclib		CDK
	Voruciclib is an orally active and selective CDK inhibitor (Ki: 0.626 nM-9.1 nM). Voruciclib represses the expression of MCL-1 in multiple models of diffuse large B-cell lymphoma. Voruciclib effectively blocks CDK9, the ...		CDK
T16040	Mepazine	Pecazine	Apoptosis , MALT
	Mepazine (Pecazine) is a potent and selective inhibitor of MALT1. Mepazine inhibits GSTMALT1 full length and GSTMALT1 325-760 with IC50s of 0.83 μM and 0.42 μM. Mepazine enhances apoptosis and affects the cell viability.		Apoptosis , MALT
T3549	Avadomide	CC 122	Apoptosis , E1/E2/E3 Enzyme , Ligand for E3 Ligase
	Avadomide (CC 122) is an orally available pleiotropic pathway modulator with potential antineoplastic activity.		Apoptosis , E1/E2/E3 Enzyme , Ligand for E3 Ligase
T14367	AZ1495		IRAK , CDK , Haspin Kinase
	AZ1495 is an oral active inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4), with IC50 values of 5 nM and 23 nM for IRAK4 and IRAK1, respectively. Which Shows activity in treatment of mutant MYD88L265P diffu...		IRAK , CDK , Haspin Kinase
T5354	IRAK4-IN-7	CA-4948	IRAK
	IRAK4-IN-7 (CA-4948) is a selective and potent IRAK4 kinase inhibitor with in vivo activity in a TLR4-induced cytokine release model.		IRAK
T2558	Cladribine	2-chlorodeoxyadenosine,2-Chloro-2′-deoxyadenosine,CldAdo,2CdA	Apoptosis , Adenosine deaminase
	Cladribine (2CdA), an adenosine deaminase inhibitor, is utilized in the treatment of lymphoproliferative diseases.		Apoptosis , Adenosine deaminase
T77367	Urelumab	BMS-663513,BMS-66513	Others
	Urelumab(BMS-66513) is a humanized IgG4 monoclonal antibody, often used as a CD137 agonist.Urelumab has potential antitumor activity, potentiating tumor cell killing by T-cells and natural killer cells, and enhancing the...		Others
T79485	IRAK4-IN-27		IRAK
	IRAK4-IN-27 (Compound 22) is a potent and selective IRAK4 inhibitor, demonstrating an IC50 of 8.7 nM. It effectively suppresses cell growth and induces apoptosis in the MYD88 L265P diffuse large B-cell lymphoma (DLBCL) c...		IRAK
T61767	IRAK4-IN-17
	IRAK4-IN-17 (Compound 5) is a highly potent inhibitor of IRAK4, exhibiting an impressive IC50 value of 1.3 nM [1]. This compound is particularly valuable for research focused on large B-cell lymphoma (DLBCL) [1].
T27615	INUB
	iNUB is a NEMO-Ub binding inhibitor. iNUB inhibits TNFα induced NF-κB signaling and has selectively toxic to IKK/NF-κB dependent ABC-DLBCL.
T38096	MLT-231
	MLT-231, a potent and highly selective allosteric MALT1 inhibitor, has an IC50 of 9 nM and specifically inhibits endogenous BCL10 cleavage with an IC50 of 160 nM. It exhibits antitumor activity in an ABC-DLBCL type xenog...
T26688	Avadomide HCl	Avadomide hydrochloride,CC122, Avadomide HCl,CC-122,CC 122 HCl
	Avadomide is an orally available pleiotropic pathway modulator with potential antineoplastic activity. CC-122 mimics an interferon response and has antitumor activity in DLBCL CC-122 binds Cereblon (CRBN) and promotes de...
T77713	BTM-3566	BTM 3566,BTM3566	Apoptosis
	BTM-3566 activates the ISR through the mitochondrial protease OMA1.BTM-3566 induces apoptosis in cancer cells. BTM-3566 overactivates the mitochondrial ISR to study DLBCL.		Apoptosis
T73869	BCL6 PROTAC 1
	BCL6 PROTAC 1 is a selective B-cell lymphoma 6 (BCL6) proteolysis targeting chimera (PROTAC) that inhibits the BCL6 cell reporter with an IC50 value of 8.8 µM and significantly degrades BCL6 in diffuse large B-cell lymph...
T77940	Tazemetostat de(methyl morpholine)-COOH		Ligands for Target Protein for PROTAC
	Tazemetostat de(methyl morpholine)-COOH (compound 7), a PROTAC ligand for EZH2, facilitates the synthesis of PROTACs that target this enzyme. These EZH2 degraders exhibit potent inhibition of cell viability in diffuse la...		Ligands for Target Protein for PROTAC
T81696	NBI-961
	NBI-961, a potent NEK2 inhibitor, suppresses proteasomal degradation and effectively induces G2/mitosis arrest and apoptosis within diffuse large B cell lymphoma (DLBCL) cells [1].
T62680	(R)-MLT-985
	(R)-MLT-985 (compound 11) is a potent inhibitor of MALT1 protease (IC50: 3 nM). (R)-MLT-985 has an IC50 value of 20 nM for MALT1-dependent IL-2 in Jurkat cells.(R)-MLT-985 inhibits growth and aberrant CARD11/BCL10/MALT1 ...
T77070	Loncastuximab
	Loncastuximab (RB4v1.2), an anti-CD19 monoclonal antibody, exhibits antitumor properties and holds potential for treating non-Hodgkin's lymphoma (NHL), specifically diffuse large B-cell lymphoma (DLBCL) [1] [2].
T82994	Anzurstobart	BMS-986351,CC-95251
	Anzurstobart (CC-95251; BMS-986351), a fully human monoclonal anti-SIRPα antibody with high affinity, inhibits CD47-SIRPα interaction. It potentiates macrophage-mediated phagocytosis of DLBCL cell lines in co-culture ass...
T78875	BTM-3528		Mitochondrial Metabolism
	BTM-3528 is a mitochondrial protease OMA1 activator that induces an overactivation of the mitochondrial integrated stress response (ISR). It promotes OMA1-dependent cleavage of DELE1 and OPA1, leading to mitochondrial fr...		Mitochondrial Metabolism
T62403	DM-01
	DM-01 is a potent and selective inhibitor of EZH2. DM-01 can be used to study diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL) and SNF5/INI-1/SMARCB1 gene-associated solid tumours.
T61153	Mepazine hydrochloride
	Mepazine hydrochloride (Pecazine hydrochloride) is a potent and selective inhibitor of the MALT1 protease, with IC50 values of 0.83 μM for GSTMALT1 full length and 0.42 μM for GSTMALT1 325-760. It enhances apoptosis and ...
T63262	IRAK4-IN-15
	IRAK4-IN-15 is a selective and potent IRAK4 inhibitor (IC50: 0.002 μM) with good human PK prediction and low intrinsic clearance.IRAK4-IN-15 in combination with Acalabrutinib exhibited potent synergistic in vitro activit...
T74664	KTX-582
	KTX-582 is a potent IRAK4 degrader, exhibiting DC50 values of 4 nM for IRAK4 and 5 nM for Ikaros. It efficiently induces apoptosis in MYD88 MT DLBCL and has demonstrated effectiveness in inducing in vivo tumor regression...
T79801	TCIP 1		Epigenetic Reader Domain
	TCIP 1 is a small molecule in the category of transcriptional/epigenetic covalent inhibitor probes (TCIPs) that forms covalent bonds with molecules targeting BCL6 and BRD4. This compound facilitates cell death gene expre...		Epigenetic Reader Domain
T63278	IRAK4-IN-14
	IRAK4-IN-14 is a selective, potent, orally active IRAK4 inhibitor (IC50: 0.003 μM) with favorable PK parameters in rats and mice. effect.

Compounds

Voruciclib

T10096L

Target: Apoptosis, MALT

Avadomide

T3549

Synonym: CC 122

Target: Apoptosis, E1/E2/E3 Enzyme, Ligand for E3 Ligase

AZ1495

T14367

Synonym:

Target: IRAK, CDK, Haspin Kinase

Synonym: 2-chlorodeoxyadenosine,2-Chloro-2′-deoxyadenosine,CldAdo,2CdA

Target: Apoptosis, Adenosine deaminase

Urelumab

T77367

Synonym: BMS-663513,BMS-66513

Synonym: Avadomide hydrochloride,CC122, Avadomide HCl,CC-122,CC 122 HCl

Target:

BTM-3566

T77713

Synonym: BTM 3566,BTM3566

Tazemetostat de(methyl morpholine)-COOH

T77940

Synonym:

Target: Ligands for Target Protein for PROTAC

Synonym: BMS-986351,CC-95251

Target: Mitochondrial Metabolism

Mepazine hydrochloride

Target: Epigenetic Reader Domain

Cat No.	Product Name	Species	Expression System
TMPJ-01337	IL-21R Protein, Mouse, Recombinant (aa 20-236, His)	Mouse	Human Cells
	Interleukin-21 receptor (IL-21R) is a type I transmembrane glycoprotein within the class I cytokine receptor family, type 4 subfamily. IL-21R is expressed mainly on B cells, NK cells, and activated T cells, but is also f...

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Recombinant Proteins