chk1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T10791	CHK1-IN-3		Chk
	CHK1-IN-3 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 0.4 nM).		Chk
T10792L	CHK1-IN-4 hydrochloride	CHK1-IN-4 hydrochloride（2120398-41-4 Free base）	Chk
	CHK1-IN-4 hydrochloride is a potent inhibitor of checkpoint kinase 1 (chk1). CHK1-IN-4 hydrochloride potently inhibits chk1 phosphorylation in the tumor cells. CHK1-IN-4 hydrochloride has anti-tumor activity.		Chk
T40091	Chk1-IN-6	Chk1-IN-6
	Chk1-IN-6 is a potent, selective, and orally bioavailable CHK1 inhibitor candidate.
T37098	Chk1-IN-5	Chk1-IN-5
	Chk1-IN-5 is a highly effective inhibitor of checkpoint kinase 1 (Chk1), which hinders the phosphorylation of Chk1 and effectively suppresses tumor growth in a colon cancer xenograft model[1].
T10790	CHK1-IN-2		Chk
	CHK1-IN-2 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 6 nM).		Chk
T10793	CHK1 inhibitor	GDC-0575 analog	Chk
	CHK1 inhibitor (GDC-0575 analog) is a CHK1 inhibitor.		Chk
T10792	CHK1-IN-4		Chk
	CHK1-IN-4 is a potent inhibitor of checkpoint kinase 1 (chk1) and potently inhibits chk1 phosphorylation in the tumor cells with anti-tumor activity.		Chk
T82393	FLT3/CHK1-IN-1
	Compound 18, also known as FLT3/CHK-IN-1, is a dual inhibitor targeting FLT3 and CHK1, exhibiting over 1700-fold selectivity towards c-KIT and significantly diminishing hERG affinity, with an IC50 of 58.4 μM. It demonstr...
T6028	PF 477736	PF 00477736,PF-477736,PF-736,PF-00477736,PF477736	c-Fms , VEGFR , FGFR , FLT , c-RET , Chk , CDK , Src , Aurora Kinase
	PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (CSF1R), Ret and Yes.
T27407	GDC0575 monohydrochloride	ARRY-575,GDC-0575,GDC 0575,ARRY575,GDC0575	Chk
	GDC0575 monohydrochloride (ARRY575) is a potent and selective inhibitor of cell cycle checkpoint kinase 1 (Chk1) with an IC50 of 1.2 nM. GDC-0575 specifically binds to and inhibits Chk1; this may result in tumor cells by...		Chk
T7300	GDC-0575	ARRY-575,RG7741	Chk
	GDC-0575 (ARRY-575) is a highly-selective oral small-molecule Chk1 inhibitor(IC50 of 1.2 nM).		Chk
T7080	CCT245737	SRA737	Chk
	CCT245737 (SRA737) is an orally active and selective Chk1 inhibitor (IC50: 1.3 nM); CCT245737 shows much less activity against Chk2 (IC50: 2440 nM).		Chk
T6350	CHIR-124	CHIR124,CHIR 124	Apoptosis , GSK-3 , FLT , Chk , PDGFR , Src
	CHIR-124 is an effective Chk1 inhibitor (IC50: 0.3 nM). It has 2, 000-fold selectivity against Chk2, 500- to 5, 000-fold less activity against Cdc2 and CDK2/4.		Apoptosis , GSK-3 , FLT , Chk , PDGFR , Src
T6931	PD0166285	PD-166285	Apoptosis , Wee1 , Chk
	PD0166285 is a potent Wee1 and Chk1 inhibitor with activity at nanomolar concentrations.PD0166285 is a novel G2 checkpoint abrogator.		Apoptosis , Wee1 , Chk
T6093	AZD-7762	AZD7762	Chk
	AZD-7762, an effective and specific inhibitor of Chk1（IC50=5 nM）, is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck.		Chk
T21331	SAR-020106		Chk
	SAR-020106 is a potent, ATP-competitive, and selective CHK1 inhibitor with an IC50 of 13.3 nmol/L on the isolated human enzyme.		Chk
T2517	SCH900776	MK 8776,MK-8776	Chk , CDK
	SCH900776 (MK-8776) is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities.		Chk , CDK
T6084	Rabusertib	LY2603618,IC-83	Chk , PDK , Autophagy
	Rabusertib (IC-83) is an inhibitor of the cell cycle checkpoint kinase 1 (chk1) with potential chemopotentiating activity. Rabusertib has been used in trials studying the treatment of Cancer, Solid Tumors, Advanced Cance...		Chk , PDK , Autophagy
T71259	GNE-900	GNE900,GNE 900	Apoptosis , Chk
	GNE-900 is an ATP-competitive ChK1 inhibitor with selective and oral activity.GNE-900 inhibits ChKl and ChK2 with IC50 values of 0.0011 and 1.5 µM, respectively.GNE-900 enhances DNA damage and induces apoptosis. GNE-900 ...		Apoptosis , Chk
T4310	Prexasertib	LY2606368	Apoptosis , Chk
	Prexasertib (LY2606368) is an inhibitor of checkpoint kinase 1 (chk1) with potential antineoplastic activity.		Apoptosis , Chk