Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GDC0575 monohydrochloride (ARRY575) is a potent and selective inhibitor of cell cycle checkpoint kinase 1 (Chk1) with an IC50 of 1.2 nM. GDC-0575 specifically binds to and inhibits Chk1; this may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases, which permits the cells to undergo DNA repair prior to entry into mitosis.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 63.00 | |
2 mg | In stock | $ 89.00 | |
5 mg | In stock | $ 128.00 | |
10 mg | In stock | $ 183.00 | |
25 mg | In stock | $ 329.00 | |
50 mg | In stock | $ 473.00 | |
100 mg | In stock | $ 675.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 152.00 |
Description | GDC0575 monohydrochloride (ARRY575) is a potent and selective inhibitor of cell cycle checkpoint kinase 1 (Chk1) with an IC50 of 1.2 nM. GDC-0575 specifically binds to and inhibits Chk1; this may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases, which permits the cells to undergo DNA repair prior to entry into mitosis. |
Targets&IC50 | Chk1:1.2 nM |
Synonyms | ARRY-575, GDC-0575, GDC 0575, ARRY575, GDC0575 |
Molecular Weight | 414.73 |
Formula | C16H21BrClN5O |
CAS No. | 1196504-54-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/ml (144.67 mM)
You can also refer to dose conversion for different animals. More
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GDC0575 monohydrochloride 1196504-54-7 Cell Cycle/Checkpoint Chk GDC-0575 Monohydrochloride ARRY-575 GDC-0575 GDC 0575 GDC 0575 Monohydrochloride GDC0575 Monohydrochloride ARRY575 GDC-0575 monohydrochloride ARRY 575 GDC0575 inhibitor inhibit