cardiomyocyte — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T7845	BTZO-1		Apoptosis
	BTZO-1 is an antioxidant response element (ARE) activator with cardioprotective activity.		Apoptosis
T16104	ML-9		Myosin , Akt
	ML-9 suppresses MLCK, PKA, and PKC activity with Ki values of 4, 32, and 54 μM, respectively. ML-9 is a selective and effective inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK), and stromal interaction ...		Myosin , Akt
T8786	VUT-MK142		Others
	VUT-MK142 is a new cardiomyogenic small molecule promoting the differentiation of pre-cardiac mesoderm into cardiomyocytes,which may be useful to differentiate stem cells into cardiomyocytes for cardiac repair.		Others
T2052	KY02111		Wnt/beta-catenin
	KY02111 facilitates differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling, maybe affect downstream of GSK3β and APC.		Wnt/beta-catenin
TP1035	Cyclic somatostatin	SRIF-14,Somatostatin-14	Others
	Cyclic somatostatin (SRIF-14) is a cyclic tetradecapeptide regulating many endocrine and nervous system functions.		Others
T3597	Cutamesine dihydrochloride	AGY94806 dihydrochloride,SA4503 (dihydrochloride),SA4503 dihydrochloride	Sigma receptor
	Cutamesine dihydrochloride (SA4503 dihydrochloride) is a selective σ1 receptor agonist (IC50: 17.4 nM). It shows selectivity for σ1 over σ2 receptors, and inhibits angiotensin II-induced cardiomyocyte hypertrophy in vitr...		Sigma receptor
T5483	DMX-5804	DMX-5084	MAPK
	DMX-5804 is a potent, selective MAP4K4 inhibitor, with an IC50 of 3 nM.DMX-5804 enhances cardiomyocyte survival, and reduces ischemia-reperfusion injury in mice.		MAPK
TP2158	TRV-120027 TFA	TRV-120027 TFA (1234510-46-3 free base)	RAAS , Arrestin
	TRV120027 TFA is a β-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1R) and engages ß-arrestins while blocking G-protein signaling.		RAAS , Arrestin
TN4892	Randialic acid B		Others
	Randialic acid B shows significant cell-protective effects against H2O2-induced H9c2 cardiomyocyte injury.		Others
T35832	Brain Natriuretic Peptide (1-32), rat acetate
	Brain Natriuretic Peptide (1-32), rat acetate (BNP (1-32), rat acetate) is a 32 amino acid polypeptide hormone synthesized by ventricular cardiomyocytes as a result of myocardial cell stretching (cardiomyocyte distension...
TP2158L	TRV-120027		Others
	TRV120027 is a β-arrestin-1-biased agonist of the angiotensin II receptor type 1. TRV120027 inhibits angiotensin II-mediated vasoconstriction and increases cardiomyocyte contractility.		Others
T62986	CCG-271423
	CCG-271423 is a potent and selective inhibitor of GRK5, acting on both GRK5 (IC50: 0.0021 μM) and GRK2 (IC50: 44 μM). CCG-271423 reduces Ca2+ transients and inhibits cardiomyocyte contractility.
T35875	CCG258208 hydrochloride
	GRKs-IN-1 hydrochloride, Compound 14as, has remarkable potency against and selectivity for G protein-coupled receptor kinase 2 GRK2 (IC50=130 nM) and GRK5 (IC50=7.1 μM).GRKs-IN-1 hydrochloride is a derivative 14as of pa...
T60825	FC9402
	FC9402 is a potent and selective inhibitor of sulfide quinone oxidoreductase(SQOR). FC9402 can be used in the regulation of cardiovascular that reduces cardiomyocyte hypertrophy and left ventricle (LV) fibrosis induced b...
T76252L	WLSEAGPVVTVRALRGTGSW TFA
	WLSEAGPVVTVRALRGTGSW TFA, a cardiomyocyte-specific peptide, exhibits enhanced performance through its expression in exosomes, which notably improves uptake by cardiomyocytes, reduces apoptosis within these cells, and inc...
T80130	SDF-1α (human)		CXCR
	SDF-1α (human) serves as a chemotactic agent for mononuclear cells through its interaction with the CXCR4 receptor, facilitating critical biological processes such as stem cell homing, retention, survival, and proliferat...		CXCR
T35541	Lipoxygenin
	Lipoxygenin is an inhibitor of 5-lipoxygenase (5-LO) with an IC50value of 5 μM for inhibition of 5-LO product synthesis in isolated human granulocytes stimulated with the cation ionophore A23187 .1It inhibits hedgehog-de...
T36667	2'-Deoxyadenosine-5'-triphosphate	dATP,Deoxyadenosine 5-triphosphate	DNA/RNA Synthesis , Endogenous Metabolite
	2'-Deoxyadenosine-5'-triphosphate (Deoxyadenosine 5-triphosphate) (dATP) is a naturally occurring small molecule nucleotide used in cells for DNA synthesis or replication. 2'-Deoxyadenosine-5'-triphosphate (dATP) is a su...		DNA/RNA Synthesis , Endogenous Metabolite
T36215	17R(18S)-EpETE
	17R(18S)-EpETE is an oxylipin and a cytochrome P450 metabolite of eicosapentaenoic acid .1,217R(18S)-EpETE is an activator of large-conductance calcium-activated potassium (BKCa) channels, increasing the potassium curren...