Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TRV-120027 TFA is an angiotensin II–mediated vasoconstriction inhibitor and increases cardiomyocyte contractility. TRV-120027 TFA is a β-arrestin-1-biased AT1R agonist engaging ß-arrestins while blocking G-protein signaling[1]. TRV-120027 TFA induces acute catecholamine secretion through cation channel subfamily C3 (TRPC3) coupling and promotes the formation of a macromolecular complex composed of AT1R–β-arrestin-1–TRPC3–PLCγ at the plasma membrane.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 64.00 | |
5 mg | In stock | $ 198.00 | |
10 mg | In stock | $ 315.00 | |
25 mg | In stock | $ 542.00 | |
50 mg | In stock | $ 782.00 | |
100 mg | In stock | $ 1,070.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 359.00 |
Description | TRV-120027 TFA is an angiotensin II–mediated vasoconstriction inhibitor and increases cardiomyocyte contractility. TRV-120027 TFA is a β-arrestin-1-biased AT1R agonist engaging ß-arrestins while blocking G-protein signaling[1]. TRV-120027 TFA induces acute catecholamine secretion through cation channel subfamily C3 (TRPC3) coupling and promotes the formation of a macromolecular complex composed of AT1R–β-arrestin-1–TRPC3–PLCγ at the plasma membrane. |
Targets&IC50 | the angiotensin II receptor type 1: |
In vitro | Treatment of 100 nM TRV-120027 TFA induces an [Ca2+]i increase in HEK293 cells co-transfected with AT1R, β-arrestin-1, and TRPC3, which are significantly blocked by Pyr3 pre-incubation in HEK293 cells co-transfected with Flag-AT1R-Cherry, HA-β-arrestin-1, and TRPC3-GFP[1]. Treatment of 100 nM TRV-120027 TFA significantly increases the AT1R and TRPC3 association with the immunoprecipitated β-arrestin-1 in HEK293 cells co-transfected with Flag-AT1R-cherry, HA-β-arrestin-1 and TRPC3-GFP[1]. |
In vivo | TRV-120027 TFA combined with furosemide decreases cardiac preload and afterload, systemic and renal vascular resistances, and left ventricular external work while increasing cardiac output and renal blood flow[2]. |
Synonyms | TRV-120027 TFA (1234510-46-3 free base) |
Molecular Weight | 1040.1 |
Formula | C45H68F3N13O12 |
CAS No. | TP2158 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 88 mg/mL (84.61 mM)
You can also refer to dose conversion for different animals. More
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TRV-120027 TFA TP2158 Endocrinology/Hormones GPCR/G Protein RAAS Arrestin 1234510-46-3 TRV 120027 TFA 1234510-46-3 free base TRV120027 TFA TRV-120027 TFA (1234510-46-3 free base) inhibitor inhibit