Home Tools
Log in
Cart

Cutamesine dihydrochloride

Catalog No. T3597   CAS 165377-44-6
Synonyms: AGY94806 dihydrochloride, SA4503 (dihydrochloride), SA4503 dihydrochloride

Cutamesine dihydrochloride (SA4503 dihydrochloride) is a selective σ1 receptor agonist (IC50: 17.4 nM). It shows selectivity for σ1 over σ2 receptors, and inhibits angiotensin II-induced cardiomyocyte hypertrophy in vitro and attenuates myocardial hypertrophy in vivo. In a rat model of experimental stroke, it enhances brain plasticity and sensorimotor function.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Cutamesine dihydrochloride Chemical Structure
Cutamesine dihydrochloride, CAS 165377-44-6
Pack Size Availability Price/USD Quantity
2 mg In stock $ 37.00
5 mg In stock $ 57.00
10 mg In stock $ 102.00
25 mg In stock $ 235.00
50 mg In stock $ 450.00
100 mg In stock $ 663.00
500 mg In stock $ 1,390.00
1 mL * 10 mM (in DMSO) In stock $ 117.00
Bulk Inquiry
Get quote
Select Batch  
Purity: 99%
Purity: 98.83%
Contact us for more batch information
Biological Description
Chemical Properties
Storage & Solubility Information
Description Cutamesine dihydrochloride (SA4503 dihydrochloride) is a selective σ1 receptor agonist (IC50: 17.4 nM). It shows selectivity for σ1 over σ2 receptors, and inhibits angiotensin II-induced cardiomyocyte hypertrophy in vitro and attenuates myocardial hypertrophy in vivo. In a rat model of experimental stroke, it enhances brain plasticity and sensorimotor function.
Targets&IC50 σ1:17.4 nM
In vitro The sigma receptor might be involved in several diseases in the central nervous system. SA4503, a potent σ1receptor agonist, has 103-fold higher affinity for σ1 (IC50=17.4 nM) than σ2 (IC50=1,784 nM) sites in guinea pig brain membranes. SA4503 is 14-fold selective for σ1 (Ki=4.6 nM) over σ2 (Ki=63.1 nM) sites in guinea pig brain homogenates[1]. SA4503 protects motor neuron NSC34 cells against superoxide dismutase 1 and serum free neurotoxicity. It upregulates the phosphorylation levels of Akt and extracellular signal-regulated kinase (ERK) 1/2[2]. SA4503 reduces the activation of the MAPK/ERK pathway and down-regulated the ionotropic glutamate receptor, GluR1[3].
In vivo SA4503 extends the survival time in the SOD1 g93A mice[2].
Cell Research The NSC34 cells are seeded at a density of 7000 cells per well into 96-well plates with D-MEM and transfected using Lipofectamine 2000 mixed with 2 μg /mL of plasmid vector in D-MEM for 6 h. After 6 h, the cell-culture medium is replaced with fresh D-MEM and culture and allowed to proceed for a further 42 h. The cells are then transferred to serum-free D-MEM and immediately treated with SA4503 at a final concentration of 1, 3, or 10 nM[2].
Synonyms AGY94806 dihydrochloride, SA4503 (dihydrochloride), SA4503 dihydrochloride
Molecular Weight 441.43
Formula C23H32N2O2·2HCl
CAS No. 165377-44-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (67.96 mM), sonification/heating is recommended.

TargetMolReferences and Literature

1. Lever JR, et al. Sigma1 and sigma2 receptor binding affinity and selectivity of SA4503 and fluoroethyl SA4503. Synapse. 2006 May;59(6):350-8. 2. Tuerxun T, et al. SA4503, a sigma-1 receptor agonist, prevents cultured cortical neurons from oxidative stress-induced cell death via suppression of MAPK pathway activation and glutamate receptor expression. Neurosci Lett. 2010 Jan 29;469(3):303-8.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Anti-Obesity Compound Library Neuronal Signaling Compound Library Anti-Neurodegenerative Disease Compound Library Bioactive Compounds Library Max Drug Repurposing Compound Library Immunology/Inflammation Compound Library Target-Focused Phenotypic Screening Library NO PAINS Compound Library

Related Products

Related compounds with same targets
S1R agonist 1 hydrochloride Sigma-LIGAND-1 S1R agonist 2 Siramesine S1RA hydrochloride BMY-14802 Sigma-1 receptor antagonist 1 NE-100 hydrochloride 

TargetMolDose Conversion

You can also refer to dose conversion for different animals. More

TargetMol In vivo Formulation Calculator (Clear solution)

Step One: Enter information below
Dosage
mg/kg
Average weight of animals
g
Dosing volume per animal
ul
Number of animals
Step Two: Enter the in vivo formulation
% DMSO
%
% Tween 80
% ddH2O
Calculate Reset

TargetMolCalculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculation
Molecular Weight Calculator
=
X
X

Molarity Calculator allows you to calculate the

  • Mass of a compound required to prepare a solution of known volume and concentration
  • Volume of solution required to dissolve a compound of known mass to a desired concentration
  • Concentration of a solution resulting from a known mass of compound in a specific volume
See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

X
=
X

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

=
/

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Cutamesine dihydrochloride 165377-44-6 GPCR/G Protein Sigma receptor Sigma Receptor AGY 94806 Dihydrochloride AGY94806 dihydrochloride SA-4503 Dihydrochloride SA 4503 Cutamesine Dihydrochloride AGY94806 AGY 94806 AGY94806 Dihydrochloride AGY-94806 Dihydrochloride inhibit Inhibitor SA4503 SA4503 Dihydrochloride SA 4503 Dihydrochloride AGY-94806 SA-4503 SA4503 (dihydrochloride) SA4503 dihydrochloride Cutamesine inhibitor

 

TargetMol