calcium-binding — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T11553	Heptamidine dimethanesulfonate	SBi4211 dimethanesulfonate	Others
	Heptamidine dimethanesulfonate (SBi4211 dimethanesulfonate) serves as a potent inhibitor related to Pentamidine, targeting the calcium-binding protein S100B with a dissociation constant (Kd) of 6.9 µM. It demonstrates sp...		Others
T83739	Myr-Tat-CBD3 TFA	Myr-Tat-Calcium Channel-binding Domain 3,N-myristate-Tat-CBD3
	Myr-Tat-CBD3 is a chemical compound that serves as an inhibitor of the protein-protein interaction between the N-type voltage-gated calcium channel Cav2.2 and collapsin response mediator protein 2 (CRMP2). This compound ...
T2530	Levosimendan	OR1259,OR1855	Potassium Channel , PDE , Carbonic Anhydrase , Autophagy
	Levosimendan (OR1259) is a calcium sensitizer used in the management of acutely decompensated congestive heart failure. It increases the sensitivity of the heart to calcium, thus increasing cardiac contractility without ...		Potassium Channel , PDE , Carbonic Anhydrase , Autophagy
T29067L	Upacicalcet HCl	Upacicalcet HCl(1333218-50-0 Free base)	CaSR
	Upacicalcet HCl is an intravesical calcium mimetic that inhibits excessive parathyroid hormone (PTH) secretion by directly acting on calcium-sensitive receptors in parathyroid cell membranes, thereby lowering PTH levels ...		CaSR
T14688	BMS CCR2 22		CCR
	BMS CCR2 22 is a potent and selective antagonist of CCR2 with calcium flux IC50 of 18 nM, chemotaxis IC50 of 1 nM, and binding IC50 of 5.1 nM.		CCR
T4054	Dantrolene sodium hemiheptahydrate	Dantrolene sodium hydrate,Dantrolene sodium salt,Dantrium,Sodium dantrolene	Calcium Channel , Autophagy
	Dantrolene depresses excitation-contraction coupling in skeletal muscle by binding to the ryanodine receptor 1 and decreasing intracellular calcium concentration. Ryanodine receptors mediate the release of calcium from t...		Calcium Channel , Autophagy
TQ0067	GSK484 hydrochloride	GTPL8577,AOB6992	PAD
	GSK484 hydrochloride (GTPL8577) (GTPL8577) is a specifc and reversible peptidyl arginine deiminase 4 (PAD4) inhibitor. It demonstrates high-affinity binding to PAD4 with IC50s of 50 nM in the absence of Calcium.		PAD
TP1910L1	CALP1 acetate	CALP1 acetate(145224-99-3 free base)	CaMK
	CALP1 acetate is a calmodulin (CaM) agonist (Kd of 88 µM) that binds to the CaM EF-hand/Ca2+-binding site. CALP1 blocks calcium influx and apoptosis (IC50 of 44.78 µM) by inhibiting the open of calcium channel. CALP1 blo...		CaMK
T0806	Flunarizine dihydrochloride	Flunarizine 2HCl,KW-3149,R14950	Calcium Channel , Dopamine Receptor , Sodium Channel
	Flunarizine dihydrochloride (R14950) is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. Flunarizine dihydrochloride (R14950) is effective in the prophylaxis of mig...		Calcium Channel , Dopamine Receptor , Sodium Channel
T3979	Emedastine	LY188695,Emadine	Histamine Receptor
	Emedastine (LY188695) is a second generation, selective histamine H1 receptor antagonist with anti-allergic activity. Emedastine reversibly and competitively blocks histamine by binding to H1 receptors, thus blocking its...		Histamine Receptor
TP1926	WRW4 TFA(878557-55-2 free base)	WRW4	Others
	WRW4 TFA (878557-55-2 free base) is a specific formyl peptide receptor-like 1 (FPRL1) antagonist, inhibits WKYMVm binding to FPRL1 with an IC50 of 0.23 μM. WRW4 TFA(878557-55-2 free base) specifically inhibits the increa...		Others
T5244	Aminomalonic acid	2-Aminopropanedioic Acid,Aminomalonate	Others , Endogenous Metabolite
	Aminomalonic acid (Aminomalonate) (Ama) was first detected in alkaline hydrolysates of proteins in 1984. Ama has been isolated from proteins of Escherichia coli and human atherosclerotic plaque. The presence of Ama has i...		Others , Endogenous Metabolite
T22530	6-Chloromelatonin		Melatonin Receptor , Dopamine Receptor
	6-Chloromelatonin is a potent melatonin receptor agonist, a 5-methoxyindole compound that competes for the same presynaptic melatonin receptor sites in the rabbit retina and inhibits the calcium-dependent release of [3H]...		Melatonin Receptor , Dopamine Receptor
T37807	JTV 519 fumarate
	Ryanodine receptor (RyR) inhibitor; stabilizes RyR2 in a closed conformation. Exhibits antiarrhythmic and cardioprotective properties in vivo. Hunt et al (2007) K201 (JTV519) suppresses spontaneous Ca2+ release and [3H]r...
TP1559L	Ziconotide Acetate (107452-89-1 free base)	Prialt,Ziconotide Acetate	Calcium Channel
	Ziconotide Acetate (107452-89-1 free base) (Prialt) is an analgesic agent and has been used to treat neuropathic and non-neuropathic pain. Ziconotide Acetate (107452-89-1 free base) acts by binding to N-type calcium chan...		Calcium Channel
T7963	2,4-Dihydroxypyridine		Others
	2,4-Dihydroxypyridine is a pyridine derivative that acts as a chelating agent binding to metal ions and forming complexes. It is used as a reagent for determining the concentration of various ions, such as calcium, magne...		Others
T0267	Zonisamide	AD 810,CI 912	Calcium Channel , Sodium Channel , Carbonic Anhydrase
	Zonisamide (AD 810), a sulfonamide anticonvulsant, is approved for use as an adjunctive treatment in adults with partial-onset seizures. It may inhibit a carbonic anhydrase although this is not one of the main mechanisms...		Calcium Channel , Sodium Channel , Carbonic Anhydrase
T22794	G36	G-36	Estrogen Receptor/ERR
	G36 is a cell-permeable non-steroidal antagonist of GPER. G36 inhibits activation by either 17β-estradiol or the GPER-selective agonist G-1 (IC50 = 112 and 165 nM, respectively). G36 has no detectable binding activity to...		Estrogen Receptor/ERR
T70036	AJG-049 HCl
	AJG-049 HCl is a calcium channel antagonist that inhibits L-type Ca2+ channels via diltiazem-binding site(s).
T70037	AJG-049 free base
	AJG-049 free base is a calcium channel antagonist that inhibits L-type Ca2+ channels via diltiazem-binding site(s).