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Flunarizine dihydrochloride

Catalog No. T0806   CAS 30484-77-6
Synonyms: Flunarizine 2HCl, KW-3149, R14950

Flunarizine dihydrochloride (R14950) is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. Flunarizine dihydrochloride (R14950) is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy.

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Flunarizine dihydrochloride Chemical Structure
Flunarizine dihydrochloride, CAS 30484-77-6
Pack Size Availability Price/USD Quantity
500 mg In stock $ 39.00
1 mL * 10 mM (in DMSO) In stock $ 43.00
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Purity: 100%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Flunarizine dihydrochloride (R14950) is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. Flunarizine dihydrochloride (R14950) is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy.
Targets&IC50 Calcium channel:68 nM(Ki)
Synonyms Flunarizine 2HCl, KW-3149, R14950
Molecular Weight 477.42
Formula C26H28Cl2F2N2
CAS No. 30484-77-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 2.4 mg/mL (5 mM)

DMSO: 23.9 mg/mL (50 mM)

TargetMolReferences and Literature

1. Uebele VN, et al. Cell Biochem Biophys. 2009;55(2):81-93.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Neurodegenerative Disease Compound Library Anti-Cancer Clinical Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Drug Library GPCR Compound Library Bioactive Compounds Library Max CNS-Penetrant Compound Library Anti-Obesity Compound Library Metabolism Compound Library Anti-Parkinson's Disease Compound Library

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Sodium Channel inhibitor 2 Dyclonine hydrochloride 20(S)-Ginsenoside Rg3 GX-674 Mepivacaine hydrochloride Permethrin Bulleyaconitine A PF 04531083

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Keywords

Flunarizine dihydrochloride 30484-77-6 GPCR/G Protein Membrane transporter/Ion channel Metabolism Neuroscience Dopamine Receptor Calcium Channel Sodium Channel R-14950 inhibit Flunarizine 2HCl Na channels Na+ channels Flunarizine Flunarizine Dihydrochloride Ca channels R 14950 KW 3149 Ca2+ channels KW-3149 R14950 KW3149 Inhibitor inhibitor

 

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