cyp1a2 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T37784	2,6-Dimethylquinoline		P450
	2,6-Dimethylquinoline is a natural product extracted from the roots of Peucedantu praeruptorum. 2,6-Dimethylquinoline is an inhibitor of CYP1A2 and CYP2B6 with an IC50 of 3.3 and 480 µM, respectively.		P450
T0778	Phenacetin	Acetophenetidin	COX
	Phenacetin (Acetophenetidin) is a phenylacetamide that was formerly used in ANALGESICS but nephropathy and METHEMOGLOBINEMIA led to its withdrawal from the market.		COX
T7699	AZD7325	AZD-7325	P450 , GABA Receptor
	AZD7325 (AZD-7325) is a GABA-Aα2,3 -selective receptor modulator.		P450 , GABA Receptor
T2949	Alizarin	Mordant Red 11,Anthraquinonic	P450
	Alizarin (Mordant Red 11), a red dye derived from the roots of plants of the madder genus, inhibits P450 isoform CYP1A1( IC50 = 6.2 μM), CYP1A2 (IC50 =10.0 μM )and CYP1B1(IC50 = 2.7 μM).		P450
T50053	Lofemizole		P450
	Lofemizole is an antagonist of CYP1A2.		P450
T7696	3-Cyano-7-ethoxycoumarin		Others
	3-Cyano-7-ethoxycoumarin is cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2 .		Others
T35716	N-desmethyl Olanzapine	4'-Desmethylolanzapine	P450 , Drug Metabolite
	N-desmethyl Olanzapine is a metabolite of the atypical antipsychotic compound Olanzapinec, which is formed through the oxidative metabolism of olanzapine by the cytochrome 450 (CYP) isoenzyme CYP1A2.		P450 , Drug Metabolite
TN3013	4,5-Dimethoxycanthin-6-one	Methylnigakinone	P450 , Antibacterial , PDE
	4,5-Dimethoxycanthin-6-one is an alkaloid isolated from Picrasma quassioides BENNET (Simaroubaceae).4,5-Dimethoxycanthin-6-one was isolated from Picrasma quassioides BENNET (Simaroubaceae) with antimicrobial activity.4,5...		P450 , Antibacterial , PDE
T11218	ε-Viniferin	epsilon-Viniferin	P450
	ε-Viniferin (epsilon-Viniferin) a dimer of resveratrol, shows the inhibitory effects of epsilon-viniferin on human CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2B6, CYP2E1, CYP3A4 and CYP4A activities.		P450
TN1702	Glycycoumarin		P450 , JNK , AMPK , Autophagy
	Glycycoumarin is an estrogen agonist, it shows moderate inhibitory effects against CYP1A2 and CYP2B6.		P450 , JNK , AMPK , Autophagy
T3585	TMS	(E)-2,3',4,5'-tetramethoxystilbene,2,3',4,5'-Tetramethoxystilbene	P450
	TMS (2,3',4,5'-Tetramethoxystilbene) is a very selective and potent competitive inhibitor of P450 1B1 (CYP1A1).		P450
T3818	Fraxinol		Others , P450
	Fraxinol is a predicted metabolite generated by BioTransformer¹ that is produced by the metabolism of 5, 7-dimethoxy-2h-chromen-2-one. It is generated by cyp1a2, cyp2a6, cyp2b6, cyp2c9, cyp2c19, and cyp2e1 enzymes via an...		Others , P450
T7472	7-Hydroxyflavone		P450
	7-Hydroxyflavone is a potent inhibitor of CYP1A1 with a Ki value of 0.015 μM and exhibits 6-fold greater selectivity for CYP1A1 over CYP1A2.with anti-inflammatory activity		P450
T2878	Ginsenoside Rd	Panaxoside Rd,Sanchinoside Rd,Gypenoside VIII	P450 , Calcium Channel , NF-κB , COX , Endogenous Metabolite
	Ginsenoside Rd (Gypenoside VIII) may have properties that inhibit or prevent the growth of tumors.
T3824	Jaceosidin		Apoptosis , BCL , COX , UGT
	Jaceosidin has anti-oxidative activity. Jaceosidin has anti-inflammatory activity, also a microglial inhibitor with anti-neuroinflammation activity. aceosidin has anticancer activity, modulates the ERK/ATM/Chk1/2 pathway...		Apoptosis , BCL , COX , UGT
T4567	Sulfaphenazole	Plisulfan,Raziosulfa,Depocid,Depotsulfonamide	P450 , Antibacterial
	Sulfaphenazole (Plisulfan) is an inhibitor of CYP2C9 (Ki: 0.3 μM) that demonstrates at least 100-fold selectivity over other CYP450 isoforms (Ki: 63/29 μM for CYP2C8/CYP2C18, respectively, and no activity at CYP1A1, CYP1...		P450 , Antibacterial
T5582	β-Apo-8'-carotenal	trans-β-apo-8'-carotenal,Apocarotenal	Others , P450
	β-Apo-8'-carotenal (Apocarotenal) is a carotenoid found in spinach and citrus fruits. Apocarotenal is used in fat-based food (margarine, sauces, salad dressing), beverages, dairy products, and sweets.		Others , P450
T3424	Ezutromid	BMN 195,VOX-C1100,SMT C1100	Others
	Ezutromid (BMN 195) is a translation modulator of Small utrophin (EC50: 0.4 uM). Ezutromid is an orally bioavailable small molecule that transcriptionally upregulates the utrophin gene, increasing both utrophin mRNA and ...		Others
T7410	Furafylline		P450
	Furafylline is a selective inhibitor of human cytochrome P450 (CYP)1A2 (IC50 : 0.07 µM),		P450
T9704	1-Ethynylpyrene		P450
	1-Ethynylpyrene is an aryl acetylenic inhibitor of CYTP450 1A1(IC50=0.18 μM), 1A2(IC50 = 0.32 μM), and 2B1(IC50 = 0.04 μM).		P450