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2,6-Dimethylquinoline

Name: 2,6-Dimethylquinoline
Brand: TargetMol
SKU: T37784
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T37784Cas No. 877-43-0

2,6-Dimethylquinoline is a natural product extracted from the roots of Peucedantu praeruptorum. 2,6-Dimethylquinoline is an inhibitor of CYP1A2 and CYP2B6 with an IC50 of 3.3 and 480 µM, respectively.

2,6-Dimethylquinoline

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Purity: 99.89%

Catalog No. T37784Cas No. 877-43-0

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$34	-	In Stock
1 mL x 10 mM (in DMSO)	$29	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.89%

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COA HNMR LCMS

Product Introduction

2,6-Dimethylquinoline AI Summary

2,6-Dimethylquinoline exhibits inhibitory activity against several cytochrome P450 enzymes. It has an IC50 value of 3300.0 nM for recombinant human cytochrome P450 1A2. For human cytochrome P450 2A6, the IC50 value is approximately 280000.0 nM, while for mouse cytochrome P450 2A5, the IC50 value is around 40000.0 nM. The ratio of IC50 for human CYP2A6 compared to mouse CYP2A5 is about 7.0, indicating a potential species-specific difference in the inhibitory potency..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	2,6-Dimethylquinoline is a natural product extracted from the roots of Peucedantu praeruptorum. 2,6-Dimethylquinoline is an inhibitor of CYP1A2 and CYP2B6 with an IC50 of 3.3 and 480 µM, respectively.
Targets&IC50	CYP1A2:3.3 μM, CYP2B6:480 μM

Chemical Properties

Molecular Weight	157.21
Formula	C₁₁H₁₁N
Cas No.	877-43-0
Smiles	Cc1ccc2nc(C)ccc2c1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (318.05 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (12.72 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.3609 mL	31.8046 mL	63.6092 mL	318.0459 mL
5 mM	1.2722 mL	6.3609 mL	12.7218 mL	63.6092 mL
10 mM	0.6361 mL	3.1805 mL	6.3609 mL	31.8046 mL
20 mM	0.3180 mL	1.5902 mL	3.1805 mL	15.9023 mL
50 mM	0.1272 mL	0.6361 mL	1.2722 mL	6.3609 mL
100 mM	0.0636 mL	0.3180 mL	0.6361 mL	3.1805 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc