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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T80558 | Anti-Mouse CD117 Antibody | c-Kit | |
Anti-Mouse CD117 Antibody, a rat-derived IgG2b isotype, acts as an inhibitor specific to the mouse CD117 antigen. | |||
T3452 | ISCK03 | c-Kit | |
ISCK03 is a selective SCF/c-Kit inhibitor. | |||
T5409 | AZD3229 | c-Kit | |
AZD3229 is a potent pan-KIT mutant inhibitor for the treatment of gastrointestinal stromal tumors. It demonstrates potent single-digit nM growth inhibition across a broad cell panel. | |||
T9689 | M4205 | c-Kit | |
M4205 is an inhibitor of c-Kit exhibiting high activity on c-Kit mutations in exons 11, 13, 17. | |||
T5109 | Avapritinib | BLU-285 | PDGFR , c-Kit |
Avapritinib (BLU-285) is a dual inhibitor of the mutant KIT receptor (KIT D816V, IC50: 0.27 nM) and PDGFRα (PDGFRα D842V, IC50: 0.24 nM). | |||
T4320 | Flumatinib | HHGV678 | Bcr-Abl , PDGFR , c-Kit |
Flumatinib (HHGV678) is an orally bioavailable tyrosine kinase inhibitor flumatinib, with potential antineoplastic activity. | |||
T7945 | SU14813 | VEGFR , PDGFR , c-Kit | |
SU14813 is a multi-receptor tyrosine kinase inhibitor with potent antiangiogenesis and antitumor activity (IC50s of 50, 2, 4, 15 nM for VEGFR2, VEGFR1, PDGFRβ and KIT). | |||
T6166 | Telatinib | Bay 57-9352 | VEGFR , PDGFR , c-Kit |
Telatinib (Bay 57-9352) is an effective inhibitor of VEGFR2/3, c-Kit, and PDGFRα. The IC50s of Telatinib forVEGFR2/3, c-Kit and PDGFRα are 6 nM/4 nM, 1 nM, and 15 nM, respectively. | |||
T10652 | Vimseltinib | DCC-3014 | c-Fms , CSF-1R , c-Kit |
Vimseltinib (DCC-3014) is a c-FMS (CSF-IR) and c-Kit dual inhibitor (IC50s: <0.01 μM and 0.1-1 μM). | |||
T2288 | Motesanib | AMG 706 | VEGFR , c-Kit |
Motesanib (AMG 706) is an orally bioavailable receptor tyrosine kinase inhibitor with potential antineoplastic activity. AMG 706 selectively targets and inhibits vascular endothelial growth factor (VEGFR), platelet-deriv... | |||
TQ0235 | AC710 | FLT , PDGFR , c-Kit | |
AC710 is a potent PDGFR inhibitor (Kds: 0.6, 1, 1.57, 1.3, 1 nM for FLT3, KIT, CSF1R, PDGFRα and PDGFRβ). | |||
T2115 | Pexidartinib | PLX-3397 | Apoptosis , c-Fms , FLT , CSF-1R , c-Kit |
Pexidartinib (PLX-3397) is a capsule formulation containing a small-molecule receptor tyrosine kinase (RTK) inhibitor of KIT, CSF1R and FLT3 with potential antineoplastic activity. | |||
T4332 | C-Kit-IN-1 | PDGFR inhibitor 1,DCC-2618 | c-Met/HGFR , c-Kit |
c-Kit-IN-1 (DCC-2618) is an effective inhibitor of c-Met and c-Kit (IC50s<200 nM). | |||
T22349 | JNJ-38158471 | CS-2660 | VEGFR , c-RET , c-Kit |
JNJ-38158471 (CS-2660), a highly selective, orally available, well tolerated VEGFR2 inhibitor with IC50 of 40 nM, inhibits closely related tyrosine kinases such as Ret and Kit with IC50 of 180 nM and 500 nM. | |||
T4191 | Multi-kinase inhibitor 1 | Multi-kinase inhibitor I | Others , Bcr-Abl , PDGFR , c-Kit |
Multi-kinase inhibitor 1 (Multi-kinase inhibitor I) is a Multi-kinase inhibitor. | |||
T2288L | Motesanib Diphosphate | Motesanib,AMG 706 | VEGFR , c-Kit |
Motesanib Diphosphate (AMG 706) is the orally bioavailable diphosphate salt of a multiple-receptor tyrosine kinase inhibitor with potential antineoplastic activity. | |||
T13178 | Toceranib | PHA 291639E,SU11654 | VEGFR , PDGFR , c-Kit |
Toceranib (PHA 291639E) phosphate is an orally active inhibitor of tyrosine kinase (RTK) receptor, and it potently inhibits PDGFR, VEGFR, and Kit(with Kis of 5 and 6 nM for PDGFRβ and Flk-1/KDR, respectively), has antitu... | |||
T1836 | AZD2932 | VEGFR , FLT , PDGFR , c-Kit | |
AZD2932 is a potent and multi-targeted kinase inhibitor VEGFR2, PDGFβ, Flt-3, and c-Kit. | |||
T0097L | Pazopanib | GW786034 | VEGFR , FGFR , PDGFR , c-Kit , Autophagy |
Pazopanib (GW786034), a small molecule inhibitor, inhibits multiple protein tyrosine kinases with potential antineoplastic activity. Pazopanib selectively inhibits VEGFR-1, -2 and -3, c-kit and PDGF-R, which may result i... | |||
T2609 | Masitinib | AB1010 | Apoptosis , FAK , c-Fms , FGFR , Bcr-Abl , PDGFR , Src , c-Kit , Hck |
Masitinib (AB1010) is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs. Since its introduction in November 2008 it has been distributed under the commercial name Masivet... |