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SU14813

Catalog No. T7945 CAS 627908-92-3

SU14813 is a multi-receptor tyrosine kinase inhibitor with potent antiangiogenesis and antitumor activity (IC50s of 50, 2, 4, 15 nM for VEGFR2, VEGFR1, PDGFRβ and KIT).

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SU14813, CAS 627908-92-3

Pack Size	Availability	Price/USD
5 mg	In stock	$ 47.00
10 mg	In stock	$ 80.00
25 mg	In stock	$ 146.00
50 mg	In stock	$ 247.00
100 mg	In stock	$ 397.00
1 mL * 10 mM (in DMSO)	In stock	$ 52.00

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Purity: 99.72%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	SU14813 is a multi-receptor tyrosine kinase inhibitor with potent antiangiogenesis and antitumor activity (IC50s of 50, 2, 4, 15 nM for VEGFR2, VEGFR1, PDGFRβ and KIT).
Targets&IC50	PDGFRβ:4 nM , c-Kit:15 nM, VEGFR1:2 nM , VEGFR2:50 nM
In vitro	SU14813, a small molecule identified from the same chemical library used to isolate sunitinib, has broad-spectrum RTK inhibitory activity through binding to and inhibition of VEGFR, PDGFR, KIT, and FLT3.?In cellular assays, SU14813 inhibited ligand-dependent and ligand-independent proliferation, migration, and survival of endothelial cells and/or tumor cells expressing these targets.?SU14813 inhibited VEGFR-2, PDGFR-beta, and FLT3 phosphorylation in xenograft tumors in a dose- and time-dependent fashion[1].
In vivo	The plasma concentration required for in vivo target inhibition was estimated to be 100 to 200 ng/mL.?Used as monotherapy, SU14813 exhibited broad and potent antitumor activity resulting in regression, growth arrest, or substantially reduced growth of various established xenografts derived from human or rat tumor cell lines.?Treatment in combination with docetaxel significantly enhanced both the inhibition of primary tumor growth and the survival of the tumor-bearing mice compared with administration of either agent alone[1].

Molecular Weight	442.48
Formula	C23H27FN4O4
CAS No.	627908-92-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 44 mg/mL (99.44 mM), Sonication is recommended.

References and Literature

1. Patyna S, et al. SU14813: a novel multiple receptor tyrosine kinase inhibitor with potent antiangiogenic and antitumor activity. Mol Cancer Ther. 2006 Jul;5(7):1774-82. 2. Dana Hu-Lowe ,et al.The Discovery and Development of SU14813, a Next-Generation Multitargeted Tyrosine Kinase Inhibitor for the Treatment of Human Malignancies.Mol Cancer Ther. 2011 Nov;10(11):2015.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Kinase Inhibitor Library Tyrosine Kinase Inhibitor Library Anti-Breast Cancer Compound Library Anti-Pancreatic Cancer Compound Library Anti-Lung Cancer Compound Library ReFRAME Related Library Anti-Prostate Cancer Compound Library Anti-Cancer Compound Library Reprogramming Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

SU14813 627908-92-3 Angiogenesis Tyrosine Kinase/Adaptors PDGFR c-Kit VEGFR SU-14813 Inhibitor SU 14813 Vascular endothelial growth factor receptor CD117 Platelet-derived growth factor receptor inhibit SCFR inhibitor

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