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Angiogenesis PDGFR AC710

AC710

Catalog No. TQ0235   CAS 1351522-04-7
Purity 98.00% Datasheet

AC710 is a potent PDGFR inhibitor (Kds: 0.6, 1, 1.57, 1.3, 1 nM for FLT3, KIT, CSF1R, PDGFRα and PDGFRβ).

AC710, CAS 1351522-04-7
Pack Size Availability Price/USD Quantity
1 mg Inquiry 52.00
5 mg Inquiry 156.00
10 mg Inquiry 231.00
25 mg Inquiry 533.00
50 mg Inquiry 960.00
100 mg Inquiry 1679.00
1 mL * 10 mM (in DMSO) Inquiry 192.00
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Purity 98.00%
Biological Description
Chemical Properties
Storage & Solubility Information
Description AC710 is a potent PDGFR inhibitor (Kds: 0.6, 1, 1.57, 1.3, 1 nM for FLT3, KIT, CSF1R, PDGFRα and PDGFRβ).
Targets&IC50
In vivo At 0.3 mg/kg of AC710, tumor growth is temporally inhibited, and growth resumes quickly thereafter. At 3 and 30 mg/kg of AC710, tumors regress completely, and the tumor volume stays suppressed for an extended period after dosing is halted. No bodyweight loss is observed in animals treated with AC710 at all doses. AC710 exhibits a significant impact on disease in a dose-dependent fashion in a mouse collagen-induced arthritis (CIA) model, at a dose as low as 3 mg/ kg for 15 days (day 0-14). At 10 and 30 mg/kg, AC710 demonstrates equivalent or slightly better efficacy in reducing the joint swelling and inflammation than dexomethasone administered at a safe dose.
Animal Research
The antitumor efficacy of AC710 is assessed in a subcutaneous flank-tumor xenograft model in athymic nude mice using the MV4-11cell line. AC710 is dosed at 0.3, 3, and 30 mg/kg for 2 weeks. Tumor growth and body weight are monitored.
Synonyms
Purity 98.00%
Appearance solid
Molecular Weight 562.70
Formula C31H42N6O4
CAS No. 1351522-04-7

Storage

-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

:

DMSO: 15mg/mL(26.66 mM; Need ultrasonic and warming)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Liu G, et al. Discovery of AC710, a Globally Selective Inhibitor of Platelet-Derived Growth Factor Receptor-Family Kinases. ACS Med Chem Lett. 2012 Sep 24;3(12):997-1002.

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Answers to questions you may have can be found in the Inhibitor Handling Instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.