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AC710

AC710
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AC710

Catalog No. TQ0235Cas No. 1351522-04-7
AC710 is a potent PDGFR inhibitor (Kds: 0.6, 1, 1.57, 1.3, 1 nM for FLT3, KIT, CSF1R, PDGFRα and PDGFRβ).
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$30In Stock
2 mg$38In Stock
5 mg$63In Stock
10 mg$98In Stock
25 mg$198In Stock
50 mg$297In Stock
100 mg$448In Stock
1 mL x 10 mM (in DMSO)$79In Stock
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Product Introduction

Bioactivity
Description
AC710 is a potent PDGFR inhibitor (Kds: 0.6, 1, 1.57, 1.3, 1 nM for FLT3, KIT, CSF1R, PDGFRα and PDGFRβ).
In vivo
At a dosage of 0.3 mg/kg, AC710 transiently inhibits tumor growth, with rapid resumption following cessation. Doses of 3 and 30 mg/kg result in complete tumor regression and prolonged suppression of tumor volume post-treatment. Notably, administration of AC710 does not lead to bodyweight loss in treated animals across all tested doses. Further, AC710 significantly mitigates disease progression in a mouse collagen-induced arthritis (CIA) model in a dose-dependent manner, starting from a low dose of 3 mg/kg over a span of 15 days (day 0-14). At increased dosages of 10 and 30 mg/kg, AC710's effectiveness in reducing joint swelling and inflammation is comparable or slightly superior to that of dexomethasone administered at a safe dose.
Animal Research
The antitumor efficacy of AC710 is assessed in a subcutaneous flank-tumor xenograft model in athymic nude mice using the MV4-11cell line. AC710 is dosed at 0.3, 3, and 30 mg/kg for 2 weeks. Tumor growth and body weight are monitored.
Chemical Properties
Molecular Weight562.7
FormulaC31H42N6O4
Cas No.1351522-04-7
Storage & Solubility Information
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 15 mg/mL (26.66 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.7771 mL8.8857 mL17.7715 mL88.8573 mL
5 mM0.3554 mL1.7771 mL3.5543 mL17.7715 mL
10 mM0.1777 mL0.8886 mL1.7771 mL8.8857 mL
20 mM0.0889 mL0.4443 mL0.8886 mL4.4429 mL

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Preparation method for in vivo formula: Take 50 μLDMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μLTween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify.
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