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AC710

Catalog No. TQ0235 CAS 1351522-04-7

AC710 is a potent PDGFR inhibitor (Kds: 0.6, 1, 1.57, 1.3, 1 nM for FLT3, KIT, CSF1R, PDGFRα and PDGFRβ).

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AC710, CAS 1351522-04-7

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	AC710 is a potent PDGFR inhibitor (Kds: 0.6, 1, 1.57, 1.3, 1 nM for FLT3, KIT, CSF1R, PDGFRα and PDGFRβ).
Targets&IC50	PDGFRβ:1 nM (Kd), PDGFRα:1.3 nM (Kd), c-Kit:1 nM (Kd), FLT3:0.6 nM (Kd), CSF1R:1.57 nM (Kd)
In vivo	At 0.3 mg/kg of AC710, tumor growth is temporally inhibited, and growth resumes quickly thereafter. At 3 and 30 mg/kg of AC710, tumors regress completely, and the tumor volume stays suppressed for an extended period after dosing is halted. No bodyweight loss is observed in animals treated with AC710 at all doses. AC710 exhibits a significant impact on disease in a dose-dependent fashion in a mouse collagen-induced arthritis (CIA) model, at a dose as low as 3 mg/ kg for 15 days (day 0-14). At 10 and 30 mg/kg, AC710 demonstrates equivalent or slightly better efficacy in reducing the joint swelling and inflammation than dexomethasone administered at a safe dose.
Animal Research	The antitumor efficacy of AC710 is assessed in a subcutaneous flank-tumor xenograft model in athymic nude mice using the MV4-11cell line. AC710 is dosed at 0.3, 3, and 30 mg/kg for 2 weeks. Tumor growth and body weight are monitored.

Molecular Weight	562.7
Formula	C31H42N6O4
CAS No.	1351522-04-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 15 mg/mL (26.66 mM), Need ultrasonic and warming

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Liu G, et al. Discovery of AC710, a Globally Selective Inhibitor of Platelet-Derived Growth Factor Receptor-Family Kinases. ACS Med Chem Lett. 2012 Sep 24;3(12):997-1002.

Related Products

Related compounds with same targets

AC710 SU14813 maleate Imatinib impurities3 CT52923 Dovitinib (TKI258) Lactate ZM323881 hydrochloride Toceranib Sunitinib-d10

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

AC710 1351522-04-7 蛋白酪氨酸激酶血管生成 PDGFR FLT c-Kit Fms like tyrosine kinase 3 Cluster of differentiation antigen 135 CD117 Platelet-derived growth factor receptor CD135 Inhibitor AC-710 AC 710 FLT3 SCFR inhibit inhibitor

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