Powder: -20°C for 3 years
In solvent: -80°C for 2 years
AC710 is a potent PDGFR inhibitor (Kds: 0.6, 1, 1.57, 1.3, 1 nM for FLT3, KIT, CSF1R, PDGFRα and PDGFRβ).
Description | AC710 is a potent PDGFR inhibitor (Kds: 0.6, 1, 1.57, 1.3, 1 nM for FLT3, KIT, CSF1R, PDGFRα and PDGFRβ). |
Targets&IC50 | PDGFRβ:1 nM (Kd), PDGFRα:1.3 nM (Kd), c-Kit:1 nM (Kd), FLT3:0.6 nM (Kd), CSF1R:1.57 nM (Kd) |
In vivo | At 0.3 mg/kg of AC710, tumor growth is temporally inhibited, and growth resumes quickly thereafter. At 3 and 30 mg/kg of AC710, tumors regress completely, and the tumor volume stays suppressed for an extended period after dosing is halted. No bodyweight loss is observed in animals treated with AC710 at all doses. AC710 exhibits a significant impact on disease in a dose-dependent fashion in a mouse collagen-induced arthritis (CIA) model, at a dose as low as 3 mg/ kg for 15 days (day 0-14). At 10 and 30 mg/kg, AC710 demonstrates equivalent or slightly better efficacy in reducing the joint swelling and inflammation than dexomethasone administered at a safe dose. |
Animal Research | The antitumor efficacy of AC710 is assessed in a subcutaneous flank-tumor xenograft model in athymic nude mice using the MV4-11cell line. AC710 is dosed at 0.3, 3, and 30 mg/kg for 2 weeks. Tumor growth and body weight are monitored. |
Molecular Weight | 562.7 |
Formula | C31H42N6O4 |
CAS No. | 1351522-04-7 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 15 mg/mL (26.66 mM), Need ultrasonic and warming
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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AC710 1351522-04-7 蛋白酪氨酸激酶 血管生成 PDGFR FLT c-Kit Fms like tyrosine kinase 3 Cluster of differentiation antigen 135 CD117 Platelet-derived growth factor receptor CD135 Inhibitor AC-710 AC 710 FLT3 SCFR inhibit inhibitor