cancer — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T13572	Cancer-Targeting Compound 1		Others
	Cancer-Targeting Compound 1 can be used in the study of hormone-related cancers, including the treatment or prevention of fibroids, uterine leiomyomas, polycystic ovarian syndrome, or hormone-dependent Cancer, among othe...		Others
T83892	33-BCRP Inhibitor	33-Breast Cancer Resistance Protein Inhibitor
	33-BCRP inhibitor is a compound that blocks the action of breast cancer resistance protein (BCRP), enhancing the susceptibility of mitoxantrone-resistant H460/MX20 lung cancer cells to the cytotoxic effects of mitoxantro...
T22336	Galloflavin		Dehydrogenase
	Galloflavin inhibits both the A and B isoforms of lactate dehydrogenase with Ki of 5.46 µM and 15.06 µM, respectively. Galloflavin is also a potential anticancer agent.		Dehydrogenase
T9929	Ramucirumab		VEGFR
	Ramucirumab is a human VEGFR-2 antagonist for the treatment of solid tumors.		VEGFR
T9552	BAZ1A-IN-1		Epigenetic Reader Domain
	BAZ1A-IN-1 is a potent BAZ1A inhibitor with the KD value of 0.52 μM for the BAZ1A bromodomain. BAZ1A-IN-1 shows good anti-survival activity against cancer cell lines with high BAZ1A expression, but weak or no activity ag...		Epigenetic Reader Domain
T2455	PFK-015	PFK15,PFK 015	Glucokinase , Autophagy
	PFK-015 (PFK15) is an effective inhibitor of PFKFB3 (IC50: 110 nM) and inhibits PFKFB3 activity in Y cells (IC50: 20 nM).		Glucokinase , Autophagy
T3755	Pinostilbene		Others
	Pinostilbene obviously attenuates the phosphorylation of c-Jun and JNK triggered by 6-OHDA.		Others
TN1046	Murrayone		Others
	Murrayone, a coumarin-containing compound derived from M. paniculata, stands out as the most bioactive substance within this species, primarily due to its unique pharmacological attributes that notably suppress cancer me...		Others
T8432	ASP4132		AMPK
	ASP4132 is an orally active AMPK activator (EC50 : 18 nM), has anti-cancer activity.		AMPK
T9963	MPT0B390		HDAC
	MPT0B390 is an inhibitor of HDAC and a TIMP3 inducer inhibiting tumor growth, metastasis, and angiogenesis.		HDAC
TN7020	Astragenol		Others
	Astragenol is an intermediate for the synthesis of astragenel derivatives. Astragenol derivatives are promising anti-inflammatory drugs in prostate cancer research.		Others
T60028	MM41		DNA/RNA Synthesis
	MM41 is a human telomeric and gene promoter DNA quadruplex stabilizer with an IC50 of <10 nM against the MIA PaCa-2 pancreatic cancer cell line.		DNA/RNA Synthesis
T6816	DASA-58		PKM
	DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.		PKM
T1394	Ibuprofen	Brufen,(±)-Ibuprofe,Motrin,Advil	COX
	Ibuprofen (Advil) is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects. Ibuprofen inhibits the activity of cyclo-oxygenase I and II, resu...		COX
T6540	Ibuprofen Lysine	Neoprofen	COX
	Ibuprofen Lysine (Neoprofen) is a non-steroidal anti-inflammatory drug.		COX
T2325	Neratinib	HKI-272	EGFR , HER
	Neratinib (HKI-272) (HKI-272) is an orally available, irreversible tyrosine kinase inhibitor for HER2 and EGFR (IC50: 59/92 nM), respectively.		EGFR , HER
T8973	HS-1793		Others
	HS-1793, a resveratrol analogue, downregulates the expression of hypoxia-induced HIF-1 and VEGF and inhibits tumor growth of human breast cancer cells in a nude mouse xenograft model		Others
T41255	Specific PXR antagonist 70		Others
	Specific PXR antagonist 70 is a selective pregnane X receptor (PXR) antagonist with an IC50 of 540 nM and Ki of 390 nM for human PCR and enhances the chemosensitivity of cancer cells.		Others
T8188	Podophyllotoxone		Others , Microtubule Associated
	Podophyllotoxinone, a natural compound found in Dysosma versipellis, shows inhibitory activity against L1210 leukemia and KB cells in vitro.		Others , Microtubule Associated
T17258	WRG-28		Discoidin Domain Receptor (DDR)
	WRG-28 is a potent and selective, allosteric discoidin domain receptor 2 (ddr2) inhibitor(IC50 : 230 nM)		Discoidin Domain Receptor (DDR)