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Cat No. | Product Name | Synonyms | Targets |
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T1418 | Bucladesine sodium | dbcAMP,Dibutyryl-cAMP sodium salt,Dibutyryl-cAMP,DC2797,Sodium dibutyryl cAMP,Bucladesine,Bucladesine sodium salt | PKA , PDE |
Bucladesine sodium (DC2797) is a cAMP analog with cell-permeable properties. Bucladesine sodium is also a cAMP-dependent protein kinase (PKA) activator and a phosphodiester (PDE) inhibitor. Bucladesine sodium has anti-in... | |||
T5315 | TCA1 | TCA-1,TCA 1 | Antibacterial , Antibiotic |
TCA1 (TCA 1) is a small molecule with activity against drug-resistant and persistent tuberculosis. | |||
T22967 | MEDICA16 | MEDICA 16 | GPR , Others , ATP Citrate Lyase |
MEDICA16 is a selective agonist for GPR40 as well as a partial agonist for GPR120. MEDICA16, an ATP-citrate lyase inhibitor, significantly reduces intracellular TG content in gastrocnemius muscle with an increase in insu... | |||
T10601 | BRCA1-IN-2 | Others | |
BRCA1-IN-2 is a cell membrane-crossing BRCA1 protein-protein interaction (PPI) inhibitor with antitumor activity that acts by disrupting the interaction of BRCA1 (BRCT)2 with proteins. | |||
T40296 | MCA17-1 | MCA17-1 | |
MCA17-1 exhibits superior bioactivity compared to the positive control, obeticholic acid (OCA), in the treatment of liver fibrosis. | |||
T72194 | KCa1.1 channel activator-1 | ||
KCa1.1 Channel Activator-1, a hybrid derivative of Quercetin, selectively stimulates the vascular KCa1.1 channels while also blocking CaV1.2 channels. Additionally, it demonstrates weak myorelaxant activity. | |||
T10600 | BRCA1-IN-1 | Others | |
BRCA1-IN-1 is a novel small-molecule-like inhibitor of BRCA1 (IC50: 0.53 μM; Ki: 0.71 μM). | |||
T72195 | KCa1.1 channel activator-2 | ||
KCa1.1 channel activator-2, a hybrid derivative of Quercetin, selectively stimulates the vascular KCa1.1 channels. This compound demonstrates significant myorelaxant activity. | |||
T38192 | Unifiram | Others | |
Unifiram is a nootropic agent.1It increases acetylcholine (ACh) release in the rat cerebral cortexin vivoand induces a long-lasting increase in the amplitude of field excitatory postsynaptic potentials (fEPSPs) in the ra... | |||
TP1895L1 | KYL acetate(676657-00-4 free base) | Ephrin Receptor | |
KYL acetate is an EphA4 receptor tyrosine kinase inhibitor (Kd = 0.8 μM); inhibits EphA4-EphrinA5 interactions (IC50 = 6.34 μM). Prevents AβO induced synaptic damage, dendritic spine loss and prevents the blocking of LTP... | |||
TP1945L1 | Pep2m, myristoylated acetate | Pep2m, myristoylated acetate(1423381-07-0 free base) | PKC |
Pep2m, myristoylated acetate is a Cell-permeable, myristoylated form of pep2m. Peptide inhibitor of the interaction between the C-terminus of the GluA2 (AMPA receptor) subunit and N-ethylmaleimide-sensitive fusion protei... | |||
T0782 | Benzthiazide | Aquatag,Lemazide,Dihydrex | Carbonic Anhydrase |
Benzthiazide (Lemazide) is used in the therapy of edema and hypertension. Like other thiazides, benzthiazide accelerates water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted ... | |||
T76590 | (d(CH2)51,Tyr(Me)2,Thr4,Orn8,des-Gly-NH29)-Vasotocin | ||
(D(CH2)51,Tyr(Me)2,Thr4,Orn8,des-Gly-NH29)-Vasotocin, serving as an oxytocin receptor antagonist, effectively nullifies the augmentation of inhibitory postsynaptic currents in CA1 pyramidal neurons by oxytocin [1]. | |||
T73099 | Etbicyphat | Trimethylopropane phosphate | |
Etbicyphat (Trimethylopropane phosphate), a potent competitive antagonist of GABA(A) receptors, binds to GABA(A)-benzodiazepine receptors and induces epileptiform activities in hippocampal CA1 neurons. | |||
TP1895 | KYL peptide | KYL | |
KYL peptide is an EphA4 receptor tyrosine kinase inhibitor (Kd = 0.8 μM); inhibits EphA4-EphrinA5 interactions (IC50 = 6.34 μM). Prevents AβO induced synaptic damage, dendritic spine loss and prevents the blocking of LTP... | |||
T37208 | NAP-1 | ||
NAP-1 is a compound with anesthetic activity.1 It increases paired-pulse inhibition in the CA1 region of rat hippocampal brain slices when used at a concentration of 100 μM. NAP-1 also induces loss of righting reflex in ... | |||
T24919 | UBP714 | UBP 714,UBP-714 | |
UBP714 is a derivative of the NMDA receptor negative allosteric modulator UBP608. It also enhanced NMDAR mediated field EPSPs in the CA1 region of the hippocampus. UBP714 is a novel template for the development of potent... | |||
T28653 | S-8510 free base | SB 737552,SB-737552,S8510,SB737552,S-8510,S 8510 | |
S-8510 is a GABA-A receptor inverse agonist. S-8510 selectively potentiated pentylenetetrazol-induced convulsion without affecting minimal electroconvulsive shock- or strychnine-induced convulsion in ddY mice. S-8510 ame... | |||
TP1945 | Pep2m, myristoylated | ||
Cell-permeable, myristoylated form of pep2m. Peptide inhibitor of the interaction between the C-terminus of the GluA2 (AMPA receptor) subunit and N-ethylmaleimide-sensitive fusion protein (NSF), a protein that regulates ... | |||
T70063 | GYKI 52466 HCl | ||
GYKI 52466 is an allosteric AMPA receptor antagonist. It selectively inhibits AMPA-induced inward currents (IC50 = 7.5 µM) over NMDA- or GABA-induced inward currents in primary rat hippocampal neurons at 50 µM but also i... | |||
T64672 | Colivelin TFA | ||
Colivelin (sequence SALLRSIPAPAGASRLLLLTGEIDLP) is composed of activity-dependent neurotrophic factor (ADNF) C-terminally fused to AGA-(C8R)HNG17, a potent HN derivative. It works as a neuroprotective peptide and activat... | |||
T37388 | Afizagabar | ||
Afizagabar (S44819) is a first-in-class, competitive, and selective antagonist at the GABA-binding site of the α5-GABAAR, with an IC50 of 585 nM for α5β2γ2 and a Ki of 66 nM for α5β3γ2. Afizagabar enhances hippocampal sy... |
Cat No. | Product Name | Synonyms | Targets |
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T9143 | D-Isoleucine | (2R,3R)-2-Amino-3-methylpentanoic acid,(R)-Isoleucine | Others |
D-Isoleucine ((2R,3R)-2-Amino-3-methylpentanoic acid) is a selective activator of Asc-1 antiporter, which enhances long-term potentiation at the hippocampal CA1-CA3 via release of endogenous D-serine. | |||
T6S2115 | Ginkgolide J | BN 52024,7-beta-Hydroxyginkgolide A | PDE |
Ginkgolide J (BN 52024) has neuroprotective activity, it can prevent A beta(1-42) induced inhibition of long-term potentiation in the CA1 region of mouse hippocampal slices. | |||
TN1601 | Effusol | Caspase | |
Effusol is a natural product, exhibits potent scavenging activity for DPPH and ABTS radicals(IC50 values of 79 μM and 2.73 μM, respectively). Effusol rescues CA1 LTP attenuated by corticosterone, defending the hippocampa... | |||
T14011 | 2-Arachidonoylglycerol | Cannabinoid Receptor , Endogenous Metabolite | |
In the central nervous system, 2-Arachidonoylglycerol is a second endogenous cannabinoid ligand | |||
T36448 | (E)-Ajoene | ||
(E)-Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities.1,2,3,4It is active against Gram-positive and Gram-negative bacteria (MICs = 10-250 and 150->500 μg/ml, respectively) and fu... |
Cat No. | Product Name | Species | Expression System |
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TMPH-03258 | Carbonic Anhydrase 1 Protein, Rat, Recombinant (His & SUMO) | Rat | E. coli |
Reversible hydration of carbon dioxide. Carbonic Anhydrase 1 Protein, Rat, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 44.2 kDa and the acce... | |||
TMPJ-00731 | Carbonic Anhydrase 1 Protein, Human, Recombinant (His) | Human | E. coli |
Carbonic Anhydrase 1 (CA1) is a cytosolic enzyme, belonging to the alpha-carbonic anhydrase family. It is highly expressed in erythrocytes and acts as an early marker for erythroid differentiation. Carbonic anhydrase 1 p... | |||
TMPH-01564 | ICA1 Protein, Human, Recombinant (His) | Human | P. pastoris (Yeast) |
May play a role in neurotransmitter secretion. | |||
TMPK-01365 | CA125/MUC16 Protein, Human, Recombinant (aa 12783-13467, His & AVI), Biotinylated | Human | HEK293 Cells |
CA125/MUC16 Protein, Human, Recombinant (aa 12783-13467, His & AVI), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 77.98 kDa and the accession number is Q8WXI7. | |||
TMPK-01359 | CA125/MUC16 Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells |
CA125/MUC16 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 31.3 kDa and the accession number is Q8WXI7. | |||
TMPH-02936 | FUCA1 Protein, Mouse, Recombinant (His & SUMO) | Mouse | E. coli |
Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. FUCA1 Protein, Mouse, Recombinant (His & SUMO) i... | |||
TMPJ-01432 | CA125/MUC16 Protein, Human, Recombinant (hFc & AVI), Biotinylated | Human | HEK293 Cells |
MUC16, also known as the CA125 antigen, is a mucin protein that may be found in type I transmembrane or secreted forms that are used monitor the progress of epithelial ovarian cancer therapy. MUC16 is over-expressed by t... | |||
TMPK-01366 | CA125/MUC16 Protein, Human, Recombinant (aa 12660-12923, His & AVI), Biotinylated | Human | HEK293 Cells |
CA125/MUC16 Protein, Human, Recombinant (aa 12660-12923, His & AVI), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 31.3 kDa and the accession number is Q8WXI7. | |||
TMPY-01734 | CA13 Protein, Human, Recombinant (His) | Human | E. coli |
The carbonic anhydrases (or carbonate dehydratases) are classified as metalloenzyme for its zinc ion prosthetic group and form a family of enzymes that catalyze the rapid interconversion of carbon dioxide and water to bi... | |||
TMPY-03282 | FUCA1 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
FUCA1 is a lysosomal enzyme involved in the degradation of fucose-containing glycoproteins and glycolipids. Mutations in FUCA1 gene are associated with fucosidosis (FUCA1D), which is an autosomal recessive lysosomal stor... | |||
TMPK-01394 | CA125/MUC16 Protein, Human, Recombinant (aa 12783-13467, His) | Human | HEK293 Cells |
CA125/MUC16 Protein, Human, Recombinant (aa 12783-13467, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 76.17 kDa and the accession number is Q8WXI7. | |||
TMPY-06614 | CA125/MUC16 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
CA125/MUC16 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 73.27 kDa and the accession number is Q8WXI7-1. |