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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T8649 | TMBIM6 antagonist-1 | BAX-inhibitor-1,BIA | mTOR |
TMBIM6 antagonist-1 (BAX-inhibitor-1) is a bax inhibitor | |||
T5210 | BAI1 | Apoptosis , BCL | |
BAI1 (Bax channel blocker) is a potent inhibitor of Bax-mediated mitochondrial cytochrome C release (IC50: 0.52 μM). | |||
T5104 | BTSA1 | Apoptosis , BCL | |
BTSA1 is a BAX activator that binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis. | |||
T12412L | PDK4-IN-1 hydrochloride | Apoptosis , PDK | |
PDK4-IN-1 hydrochloride is an anthraquinone derivative and a potent and orally active inhibitor of pyruvate dehydrogenase kinase 4 (PDK4)(IC50 value of 84 nM) | |||
T6583 | MG-101 | ALLN,Ac-LLnL-CHO,Calpain inhibitor I,Calpain inhibitor-1,MG101 | Cysteine Protease , Proteasome |
MG-101 (Calpain inhibitor I) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins. | |||
T8978 | DD1 | 3,3'-Diamino-4'-methoxyflavone,HUN85111 | Proteasome |
DD1 (HUN85111) is a proteasome inhibitor that induces human myeloid tumor-selective apoptosis. | |||
T4215 | TCS-PIM-1-4a | SMI-4a | Apoptosis , Pim |
TCS-PIM-1-4a (SMI-4a), a Pim inhibitor, blocks mTORC1 activity through activation of AMPK and kills a wide range of both myeloid and lymphoid cell lines (IC50=0.8-40 μM). | |||
T23861 | CAY10526 | CAY-10526,BTH,CAY 10526 | Prostaglandin Receptor |
CAY10526 (BTH) is a selective mPGES-1 inhibitor that acts as an inhibitor of the NF-κB signaling pathway. | |||
T6S0052 | Chelerythrine | Toddalin,Broussonpapyrine,Cheleritrine | Apoptosis , BCL , PKC , Autophagy |
1. Chelerythrine (Broussonpapyrine) may have antimanic effect . 2. Chelerythrine can inhibit telomerase activity. 3. Chelerythrine is a well-known protein kinase C inhibitor . 4. Chelerythrine has potential antiprolifera... | |||
T3824 | Jaceosidin | Apoptosis , BCL , COX , UGT | |
Jaceosidin has anti-oxidative activity. Jaceosidin has anti-inflammatory activity, also a microglial inhibitor with anti-neuroinflammation activity. aceosidin has anticancer activity, modulates the ERK/ATM/Chk1/2 pathway... | |||
T82918 | BAX-IN-1 | ||
BAX-IN-1 is a potential selective inhibitor of Bcl-2-associated X protein (BAX). | |||
T61385 | IDO1/TDO-IN-1 | ||
IDO1/TDO-IN-1 (30) is a highly effective inhibitor that targets both IDO1 and TDO enzymes with uncompetitive (Ki = 0.23 μM) and competitive (Ki = 0.73 μM) mechanisms, respectively. This compound, IDO1/TDO-IN-1 (30), exhi... | |||
T79242 | Mcl-1 inhibitor 16 | ||
Mcl-1 Inhibitor 16 (Compound 9), a platinum-based mitochondrial-targeting agent, inhibits Mcl-1 and induces Bax/Bak-dependent apoptosis in cancer cells. This compound exhibits antitumor activity and may be utilized as a ... | |||
T76033 | Humanin | ||
Humanin, a 24-amino acid anti-apoptotic peptide and Bax inhibitor, prevents Bax translocation from the cytosol to mitochondria and obstructs its activation. This mitochondria-associated peptide has neuroprotective proper... | |||
T61327 | BRD4 Inhibitor-15 | ||
BRD4 Inhibitor-15 (compound 13) is a highly potent and specific inhibitor of BRD4, effectively inhibiting it with an IC50 of 18 nM. By regulating the Bcl-2/Bax proteins and activating the caspase-3 signaling pathway, BRD... | |||
T60583 | CDK1/2/4-IN-1 | ||
CDK1/2/4-IN-1 (compound 3a) is a potent inhibitor of CDK with IC 50 values of 1.47, 0.78 and 0.87 μM for CDK1, CDK2 and CDK4, respectively. CDK1/2/4-IN-1 can be used in cancer research. CDK1/2/4-IN-1 arrests cell cycle a... | |||
T79403 | VEGFR-2-IN-36 | VEGFR | |
VEGFR-2-IN-36 (compound 15) serves as a potent VEGFR-2 inhibitor, exhibiting an IC50 value of 0.067 μM, and acts as an apoptosis inducer with demonstrated anticancer efficacy. It modulates apoptotic pathways by upregulat... | |||
T78872 | CTL-06 | ||
CTL-06, a Fatty Acid Synthase (FASN) inhibitor with an IC50 of 3 μM, induces apoptosis, while CTL-12 impedes cell cycle progression in the Sub-G1/S phase and modulates apoptotic and anti-apoptotic markers by upregulating... | |||
T78873 | CTL-12 | ||
CTL-12, a fatty acid synthase (FASN) inhibitor (IC50: 2.5 μM), induces apoptosis and disrupts the cell cycle at the Sub-G1/S phase. It upregulates caspase-9 and the apoptosis marker Bax, while downregulating the anti-apo... | |||
T71230 | VMY-1-103 | ||
VMY-1-103 is a potent CDK inhibitor, is also a novel dansylated analog of purvalanol B, was shown to inhibit cell cycle progression and proliferation in prostate and breast cancer cells more effectively than purvalanol B... |