antimitotic — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T36674	DMU-212		Apoptosis , ERK
	DMU-212 is a methylated derivative of Resveratrol , with antimitotic, anti-proliferative, antioxidant and apoptosis promoting activities. DMU-212 induces mitotic arrest via induction of apoptosis and activation of ERK1/2...		Apoptosis , ERK
T1753	D-64131		Microtubule Associated
	D-64131 is a tubulin polymerization inhibitor with an IC50 value of 0.53 μM.		Microtubule Associated
T22661	CHM-1		Apoptosis , Others , Microtubule Associated
	CHM-1 is an inducer of apoptosis, and displays potent antitumor ability in human hepatocellular carcinoma by activation of Cdc2 kinase activity. CHM-1 inhibits tubulin polymerization in vitro and in vivo.		Apoptosis , Others , Microtubule Associated
T10460	Batabulin	T138067	Apoptosis , Microtubule Associated
	Batabulin (T138067) is an antitumor compound, which binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. Batabulin affects cell morphology and leads to ce...		Apoptosis , Microtubule Associated
T20681	Estramustine	NSC-89201,NSC 89201,LEO 275,LEO275,NSC89201,LEO-275	Microtubule Associated
	Estramustine (LEO-275) is a nitrogen mustard linked to estradiol, usually as phosphate. Estramustine has been used to treat prostatic neoplasms; also has radiation protective properties. Estramustine is selectively taken...		Microtubule Associated
T4451	Estramustine phosphate sodium	Ro 21-8837/001,Estramustine phosphate disodium	Apoptosis , Microtubule Associated
	Estramustine phosphate sodium (Ro 21-8837/001) is an antimicrotubule chemotherapy agent; arrests prostate cancer cells in the G2/M phase of the cell cycle.		Apoptosis , Microtubule Associated
TP1180	Dolastatin 10	NSC 376128,DLS 10	Microtubule Associated
	Dolastatin 10 (DLS 10) is a powerful peptide with antimitotic properties, effectively inhibiting tubulin polymerization.		Microtubule Associated
T2773	Vindoline		Microtubule Associated
	Vindoline is an indole alkaloid that exhibits antimitotic activity by inhibiting microtubule assembly.		Microtubule Associated
T7565	3-Hydroxycapric acid		Endogenous Metabolite
	3-hydroxydecanoic acid is a medium-chain fatty acid. It has a role as an antimitotic and an Escherichia coli metabolite.		Endogenous Metabolite
T26046	Razoxane		Topoisomerase
	Razoxane is used as an antimitotic agent with immunosuppressive properties.		Topoisomerase
T3256	MMAF	MonoMethyl auristatin F	Others , Microtubule Associated
	MMAF (MonoMethyl auristatin F), an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin.		Others , Microtubule Associated
T0651	N-Phenylbenzylamine	Benzylaniline,Benzenemethanamine	Microtubule Associated
	A series of N-Phenylbenzylamine (Benzenemethanamine) as potential cytotoxic and antimitotic agents acting by inhibition of tubulin polymerization		Microtubule Associated
T6897	Monomethyl auristatin E	Vedotin,MMAE	Apoptosis , Microtubule Associated
	Monomethyl auristatin E (MMAE) (MMAE), an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin and also has inhibition of antibody-drug conjugates (ADCs) activity.		Apoptosis , Microtubule Associated
TN2190	Scoulerine		Apoptosis , Beta-Secretase , BACE , Parasite
	Scoulerine is an inhibitor of ß-site amyloid precursor protein cleaving enzyme 1(BACE1). Scoulerine a potent antimitotic compound that inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells.		Apoptosis , Beta-Secretase , BACE , Parasite
T15576	Indibulin	ZIO 301,D 24851	Apoptosis , Microtubule Associated
	Indibulin (D 24851) is a synthetic small molecule with antimitotic and potential antineoplastic activities.Indibulin an orally applicable inhibitor of tubulin assembly, shows potent anticancer activity with a minimal neu...		Apoptosis , Microtubule Associated
T3124	Carbendazim	Bavistin,Carbendazole,Mercarzole	Antifungal
	Carbendazim (Mercarzole) is a broad-spectrum benzimidazole antifungal with potential antimitotic and antineoplastic activities. Although the exact mechanism of action is unclear, carbendazim appears to binds to an unspec...		Antifungal
T34787	TAS-119	TAS119,TAS2104,TAS 2104,TAS-2104,TAS 119	Aurora Kinase
	TAS-119 (TAS-2104) is an orally available, selective and potent inhibitor of Aurora A with an IC50 of 1.0 nM.TAS-119 also inhibits Aurora B with an IC50 of 95 nM.TAS-119 has a higher affinity for Aurora A than for Aurora...		Aurora Kinase
T2220	2-Methoxyestradiol	NSC-659853,2-MeOE2,2-ME2	Apoptosis , Reactive Oxygen Species , Microtubule Associated , Endogenous Metabolite , HIF , Autophagy
	2-Methoxyestradiol (2-ME2) is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing endothelial cell proliferation and inducing endotheli...
T25290	DAT1	DAT-1,DAT 1
	DAT1 is an antimitotic and antiangiogenic that acts by binding to the colchicine binding site of tubulin.
T69245	Amikhelline
	Amikhelline is an antimitotic drug. It acts as a DNA intercalator and inhibits DNA polymerase.