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TAS-119

Catalog No. T34787 CAS 1453099-83-6

Synonyms: TAS119, TAS2104, TAS 2104, TAS-2104, TAS 119

TAS-119 (TAS-2104) is an orally available, selective and potent inhibitor of Aurora A with an IC50 of 1.0 nM.TAS-119 also inhibits Aurora B with an IC50 of 95 nM.TAS-119 has a higher affinity for Aurora A than for Aurora B.TAS-119 exhibits potent antitumor activity and potential antimitotic activity. TAS-119 has potent anti-tumor activity and potential anti-mitotic activity.

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TAS-119, CAS 1453099-83-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 98.00
5 mg	In stock	$ 247.00
10 mg	In stock	$ 397.00
25 mg	In stock	$ 788.00
50 mg	In stock	$ 1,230.00
100 mg	In stock	$ 1,730.00
1 mL * 10 mM (in DMSO)	In stock	$ 275.00

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Purity: 98.69%

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Description	TAS-119 (TAS-2104) is an orally available, selective and potent inhibitor of Aurora A with an IC50 of 1.0 nM.TAS-119 also inhibits Aurora B with an IC50 of 95 nM.TAS-119 has a higher affinity for Aurora A than for Aurora B.TAS-119 exhibits potent antitumor activity and potential antimitotic activity. TAS-119 has potent anti-tumor activity and potential anti-mitotic activity.
Targets&IC50	Aurora A:1 nM (IC50), Aurora B:95 nM (IC50)
In vitro	TAS-119 (30-300 nM) dose-dependently augments the growth inhibition of HeLa cells induced by three taxanes (Paclitaxel, Docetaxel, and Cabazitaxel). It specifically promotes mitotic accumulation in tumor cells over normal diploid fibroblasts. Moreover, TAS-119 amplifies the antiproliferative efficacy of Paclitaxel across a diverse array of human cancer cell lines, even those resistant to Paclitaxel.[1]
In vivo	TAS-119 (5, 10, and 30 mg/kg; oral; twice daily on day 1 and every day on day 2; Nude rats injected with HeLa-luc cells) induced pHH3 at all doses in nude rats with the HeLa-luc xenografts. The treatment induces phosphorylated histone H3 (pHH3) in nude rats with the HeLa-luc xenografts.[1]

Synonyms	TAS119, TAS2104, TAS 2104, TAS-2104, TAS 119
Molecular Weight	506.36
Formula	C23H22Cl2FN5O3
CAS No.	1453099-83-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25.32 mg/mL (50 mM)

References and Literature

1. Sootome H, et al. Aurora A Inhibitor TAS-119 Enhances Antitumor Efficacy of Taxanes In Vitro and In Vivo: Preclinical Studies as Guidance for Clinical Development and Trial Design. Mol Cancer Ther. 2020;19(10):1981-199

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Inhibitor Library Bioactive Compounds Library Max Kinase Inhibitor Library Anti-Cancer Compound Library Bioactive Compound Library

Related Products

Related compounds with same targets

JNJ-7706621 Aurora B inhibitor 1 MLN8054 Palmatine G-749 Ilorasertib SP-96 TAK-285

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Keywords

TAS-119 1453099-83-6 Cell Cycle/Checkpoint Chromatin/Epigenetic Aurora Kinase TAS119 TAS2104 TAS 2104 TAS-2104 TAS 119 inhibitor inhibit

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