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Indibulin

Catalog No. T15576   CAS 204205-90-3
Synonyms: ZIO 301, D 24851

Indibulin (D 24851) is a synthetic small molecule with antimitotic and potential antineoplastic activities.Indibulin an orally applicable inhibitor of tubulin assembly, shows potent anticancer activity with a minimal neurotoxicity. Indibulin reduces inter-kinetochoric tension, produces aberrant spindles, activates mitotic checkpoint proteins Mad2 and BubR1, and induces mitotic arrest and apoptosis.

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Indibulin Chemical Structure
Indibulin, CAS 204205-90-3
Pack Size Availability Price/USD Quantity
2 mg In stock $ 34.00
5 mg In stock $ 55.00
10 mg In stock $ 90.00
25 mg In stock $ 193.00
50 mg In stock $ 313.00
100 mg In stock $ 493.00
1 mL * 10 mM (in DMSO) In stock $ 61.00
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Purity: 99.83%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Indibulin (D 24851) is a synthetic small molecule with antimitotic and potential antineoplastic activities.Indibulin an orally applicable inhibitor of tubulin assembly, shows potent anticancer activity with a minimal neurotoxicity. Indibulin reduces inter-kinetochoric tension, produces aberrant spindles, activates mitotic checkpoint proteins Mad2 and BubR1, and induces mitotic arrest and apoptosis.
In vitro Indibulin, a synthetic inhibitor of tubulin assembly, has shown promising anticancer activity.?Using time-lapse confocal microscopy, indibulin dampens the dynamic instability of individual microtubules in live breast cancer cells.?Indibulin treatment also perturbed the localization of end-binding proteins at the growing microtubule ends in MCF-7 cells.?Indibulin reduced inter-kinetochoric tension, produced aberrant spindles, activated mitotic checkpoint proteins Mad2 and BubR1, and induced mitotic arrest in MCF-7 cells.?Indibulin-treated MCF-7 cells underwent apoptosis-mediated cell death.?Further, the combination of indibulin with an anticancer drug vinblastine was found to exert synergistic cytotoxic effects on MCF-7 cells.?Interestingly, indibulin displayed a stronger effect on the undifferentiated neuroblastoma (SH-SY5Y) cells than the differentiated neuronal cells.?Unlike indibulin, vinblastine and colchicine produced similar depolymerizing effects on microtubules in both differentiated and undifferentiated SH-SY5Y cells.
Synonyms ZIO 301, D 24851
Molecular Weight 389.83
Formula C22H16ClN3O2
CAS No. 204205-90-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (128.26 mM), sonification is recommended.

TargetMolReferences and Literature

1. Kapoor S, et al. Indibulin dampens microtubule dynamics and produces synergistic antiproliferative effect with vinblastine in MCF-7 cells: Implications in cancer chemotherapy. Sci Rep. 2018 Aug 17;8(1):12363.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Drug Library Anti-Cancer Active Compound Library Anti-Cancer Clinical Compound Library Microtubule-Targeted Compound Library Covalent Inhibitor Library Anti-Aging Compound Library Anti-Breast Cancer Compound Library Inhibitor Library Drug Repurposing Compound Library Clinical Compound Library

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Keywords

Indibulin 204205-90-3 Apoptosis Cytoskeletal Signaling Microtubule Associated D24851 Inhibitor inhibit ZIO 301 D-24851 D 24851 ZIO-301 Microtubule/Tubulin ZIO301 inhibitor

 

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