Transforming growth factor beta (TGF-β) is a multifunctional cytokine belonging to the transforming growth factor superfamily that includes three different mammalian isoforms (TGF-β 1 to 3, HGNC symbols TGFB1, TGFB2, TGFB3) and many other signaling proteins. TGFB proteins are produced by all white blood cell lineages. Activated TGF-β complexes with other factors to form a serine/threonine kinase complex that binds to TGF-β receptors. TGF-β receptors are composed of both type 1 and type 2 receptor subunits. After the binding of TGF-β, the type 2 receptor kinase phosphorylates and activates the type 1 receptor kinase that activates a signaling cascade. This leads to the activation of different downstream substrates and regulatory proteins. TGF-β also plays a crucial role in stem cell differentiation as well as T-cell regulation and differentiation. Because of its role in immune and stem cell regulation and differentiation, it is a highly researched cytokine in the fields of cancer, auto-immune diseases, and infectious disease.
Cat No. | product name / Synonyms | Species | Expression System |
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TMPJ-00100 | Artemin Protein, Human, Recombinant
Artemin Protein, Human, Recombinant
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Human | E. coli |
Human Artemin is a GDNF family ligand that is distantly related to the TGF-β superfamily of molecules. It is synthesized as a preproprotein, and contains a varia... | |||
TMPJ-00238 | Lefty-A Protein, Human, Recombinant (His)
Lefty-A Protein, Human, Recombinant (His)
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Human | Human Cells |
Left-right determination factor 2(LEFTY2) is a secreted protein which belongs to the TGF-beta family. Lefty was first identified in a screen for undifferentiated... | |||
TMPJ-00250 | LAP (TGF-beta 1) Protein, Human, Recombinant (His & Avi), Biotinylated
LAP (TGF-beta 1) Protein, Human, Recombinant (His & Avi), Biotinylated
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Human | Human Cells |
Transforming growth factor beta (TGFβ) family members are secreted in inactive complexes with a latency-associated peptide (LAP), a protein derived from the N-te... | |||
TMPJ-00255 | TGF beta 3 Protein, Human, Recombinant (Avi), Biotinylated
TGF beta 3 Protein, Human, Recombinant (Avi), Biotinylated
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Human | Human Cells |
Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell... | |||
TMPJ-00256 | Latent TGF-beta 3 Protein, Human, Recombinant (His & Avi), Biotinylated
Latent TGF-beta 3 Protein, Human, Recombinant (His & Avi), Biotinylated
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Human | Human Cells |
Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell... | |||
TMPJ-00259 | TGF beta 2 Protein, Human, Recombinant (Avi), Biotinylated
TGF beta 2 Protein, Human, Recombinant (Avi), Biotinylated
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Human | Human Cells |
Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell... | |||
TMPJ-00260 | Latent TGF-beta 2 Protein, Human, Recombinant (His & Avi), Biotinylated
Latent TGF-beta 2 Protein, Human, Recombinant (His & Avi), Biotinylated
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Human | Human Cells |
Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell... | |||
TMPJ-00271 | SMAD3 Protein, Human, Recombinant (His & Flag)
SMAD3 Protein, Human, Recombinant (His & Flag)
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Human | E. coli |
Mothers against decapentaplegic homolog 3(SMAD3) is a cytoplasm protein which belongs to the dwarfin/SMAD family. Smad proteins undergo rapid nuclear translocati... | |||
TMPJ-00622 | Latent TGF-beta 1 Protein, Cynomolgus, Recombinant (His)
Latent TGF-beta 1 Protein, Cynomolgus, Recombinant (His)
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Cynomolgus | Human Cells |
Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell... | |||
TMPJ-00663 | GDF-8 Protein, Human/Mouse/Rat, Recombinant
GDF-8 Protein, Human/Mouse/Rat, Recombinant
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Human,Mouse,Rat | Human Cells |
Growth/differentiation factor 8(Mstn, GDF-8) is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is c... | |||
TMPJ-00713 | GDF-11 Protein, Human, Recombinant
GDF-11 Protein, Human, Recombinant
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Human | Human Cells |
Growth/differentiation factor 11(GDF-11) is a secreted protein, which belongs to the transforming growth factor beta superfamily. GDF-11 controls anterior-poster... | |||
TMPJ-00771 | TGF beta 1 Protein, Mouse/Rat, Recombinant
TGF beta 1 Protein, Mouse/Rat, Recombinant
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Mouse,Rat | Human Cells |
Transforming growth factor beta 1 (TGFβ1) is the prototype of a growing superfamily of peptide growth factors and plays a prominent role in a variety of cellular... | |||
TMPJ-00772 | Latent TGF-beta 1 Protein, Mouse, Recombinant (His & Avi), Biotinylated
Latent TGF-beta 1 Protein, Mouse, Recombinant (His & Avi), Biotinylated
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Mouse | Human Cells |
Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell... | |||
TMPJ-00966 | GDF-5 Protein, Human, Recombinant
GDF-5 Protein, Human, Recombinant
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Human | E. coli |
Growth Differentiation Factor 5(GDF-5, BMP-14) is a member of the BMP family of TGFβ superfamily proteins. Human GDF-5, -6, and -7 are a defined subgroup of the ... | |||
TMPJ-01015 | INHBC Protein, Human, Recombinant (C-His)
INHBC Protein, Human, Recombinant (C-His)
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Human | Human Cells |
Inhibin beta C chain, also known as activin beta-C chain and INHBC, belongs to the TGF-beta family. INHBC forms a homodimeric or heterodimeric through associatio... | |||
TMPJ-01016 | INHBC Protein, Human, Recombinant (N-His)
INHBC Protein, Human, Recombinant (N-His)
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Human | E. coli |
Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ ... | |||
TMPJ-01108 | SMAD4 Protein, Human, Recombinant (His)
SMAD4 Protein, Human, Recombinant (His)
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Human | E. coli |
SMAD Family Member 4 (SMAD4) is a cytoplasmic protein that belongs to the Dwarfin/SMAD family. SMAD4 contains one MH1 (MAD homology 1) domain and one MH2 (MAD ho... | |||
TMPJ-01226 | Irisin Protein, Human/Mouse/Rat, Recombinant (hFc)
Irisin Protein, Human/Mouse/Rat, Recombinant (hFc)
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Human,Mouse,Rat | Human Cells |
Fibronectin type III domain-containing protein 5, the precursor of irisin, is a protein that is encoded by the FNDC5 gene.Human Irisin is synthesized as a 212 am... | |||
TMPJ-01227 | Irisin Protein, Human/Mouse/Rat, Recombinant (C-His)
Irisin Protein, Human/Mouse/Rat, Recombinant (C-His)
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Human,Mouse,Rat | Human Cells |
Fibronectin type III domain-containing protein 5, the precursor of irisin, is a protein that is encoded by the FNDC5 gene.Human Irisin is synthesized as a 212 am... | |||
TMPJ-01228 | Irisin Protein, Human/Mouse/Rat, Recombinant (N-His)
Irisin Protein, Human/Mouse/Rat, Recombinant (N-His)
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Human,Mouse,Rat | Human Cells |
Irisin Protein, Human/Mouse/Rat, Recombinant (N-His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 18-28 KDa and the... |