Home Tools
Log in
Cart

Transforming Growth Factor-β family, TGF-βs

Transforming growth factor beta (TGF-β) is a multifunctional cytokine belonging to the transforming growth factor superfamily that includes three different mammalian isoforms (TGF-β 1 to 3, HGNC symbols TGFB1, TGFB2, TGFB3) and many other signaling proteins. TGFB proteins are produced by all white blood cell lineages. Activated TGF-β complexes with other factors to form a serine/threonine kinase complex that binds to TGF-β receptors. TGF-β receptors are composed of both type 1 and type 2 receptor subunits. After the binding of TGF-β, the type 2 receptor kinase phosphorylates and activates the type 1 receptor kinase that activates a signaling cascade. This leads to the activation of different downstream substrates and regulatory proteins. TGF-β also plays a crucial role in stem cell differentiation as well as T-cell regulation and differentiation. Because of its role in immune and stem cell regulation and differentiation, it is a highly researched cytokine in the fields of cancer, auto-immune diseases, and infectious disease.

1 2 3 4
Species
Canine (5)
Cynomolgus (6)
Human (43)
Mouse (26)
Rat (13)
Rhesus (2)
Expression System
Baculovirus-Insect Cells (5)
CHO (1)
E. coli (12)
HEK293 (35)
Human Cells (21)
Yeast (1)
Tag
C-6His (3)
C-Fc (1)
C-mFc-Avi (2)
GST (3)
His (19)
N-6His (4)
N-6His-Avi (1)
N-6His-Flag (1)
N-8His-Avi (3)
N-8His-Flag (1)
N-Avi (3)
N-His (6)
N-His-Avi (1)
N-hFc (7)
None (9)
Tag Free (6)
hFc (8)
Cat No. product name / Synonyms Species Expression System
TMPJ-00100 Artemin Protein, Human, Recombinant
Artemin Protein, Human, Recombinant
Human E. coli
Human Artemin is a GDNF family ligand that is distantly related to the TGF-β superfamily of molecules. It is synthesized as a preproprotein, and contains a varia...
TMPJ-00238 Lefty-A Protein, Human, Recombinant (His)
Lefty-A Protein, Human, Recombinant (His)
Human Human Cells
Left-right determination factor 2(LEFTY2) is a secreted protein which belongs to the TGF-beta family. Lefty was first identified in a screen for undifferentiated...
TMPJ-00250 LAP (TGF-beta 1) Protein, Human, Recombinant (His & Avi), Biotinylated
LAP (TGF-beta 1) Protein, Human, Recombinant (His & Avi), Biotinylated
Human Human Cells
Transforming growth factor beta (TGFβ) family members are secreted in inactive complexes with a latency-associated peptide (LAP), a protein derived from the N-te...
TMPJ-00255 TGF beta 3 Protein, Human, Recombinant (Avi), Biotinylated
TGF beta 3 Protein, Human, Recombinant (Avi), Biotinylated
Human Human Cells
Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell...
TMPJ-00256 Latent TGF-beta 3 Protein, Human, Recombinant (His & Avi), Biotinylated
Latent TGF-beta 3 Protein, Human, Recombinant (His & Avi), Biotinylated
Human Human Cells
Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell...
TMPJ-00259 TGF beta 2 Protein, Human, Recombinant (Avi), Biotinylated
TGF beta 2 Protein, Human, Recombinant (Avi), Biotinylated
Human Human Cells
Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell...
TMPJ-00260 Latent TGF-beta 2 Protein, Human, Recombinant (His & Avi), Biotinylated
Latent TGF-beta 2 Protein, Human, Recombinant (His & Avi), Biotinylated
Human Human Cells
Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell...
TMPJ-00271 SMAD3 Protein, Human, Recombinant (His & Flag)
SMAD3 Protein, Human, Recombinant (His & Flag)
Human E. coli
Mothers against decapentaplegic homolog 3(SMAD3) is a cytoplasm protein which belongs to the dwarfin/SMAD family. Smad proteins undergo rapid nuclear translocati...
TMPJ-00622 Latent TGF-beta 1 Protein, Cynomolgus, Recombinant (His)
Latent TGF-beta 1 Protein, Cynomolgus, Recombinant (His)
Cynomolgus Human Cells
Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell...
TMPJ-00663 GDF-8 Protein, Human/Mouse/Rat, Recombinant
GDF-8 Protein, Human/Mouse/Rat, Recombinant
Human,Mouse,Rat Human Cells
Growth/differentiation factor 8(Mstn, GDF-8) is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is c...
TMPJ-00713 GDF-11 Protein, Human, Recombinant
GDF-11 Protein, Human, Recombinant
Human Human Cells
Growth/differentiation factor 11(GDF-11) is a secreted protein, which belongs to the transforming growth factor beta superfamily. GDF-11 controls anterior-poster...
TMPJ-00771 TGF beta 1 Protein, Mouse/Rat, Recombinant
TGF beta 1 Protein, Mouse/Rat, Recombinant
Mouse,Rat Human Cells
Transforming growth factor beta 1 (TGFβ1) is the prototype of a growing superfamily of peptide growth factors and plays a prominent role in a variety of cellular...
TMPJ-00772 Latent TGF-beta 1 Protein, Mouse, Recombinant (His & Avi), Biotinylated
Latent TGF-beta 1 Protein, Mouse, Recombinant (His & Avi), Biotinylated
Mouse Human Cells
Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell...
TMPJ-00966 GDF-5 Protein, Human, Recombinant
GDF-5 Protein, Human, Recombinant
Human E. coli
Growth Differentiation Factor 5(GDF-5, BMP-14) is a member of the BMP family of TGFβ superfamily proteins. Human GDF-5, -6, and -7 are a defined subgroup of the ...
TMPJ-01015 INHBC Protein, Human, Recombinant (C-His)
INHBC Protein, Human, Recombinant (C-His)
Human Human Cells
Inhibin beta C chain, also known as activin beta-C chain and INHBC, belongs to the TGF-beta family. INHBC forms a homodimeric or heterodimeric through associatio...
TMPJ-01016 INHBC Protein, Human, Recombinant (N-His)
INHBC Protein, Human, Recombinant (N-His)
Human E. coli
Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ ...
TMPJ-01108 SMAD4 Protein, Human, Recombinant (His)
SMAD4 Protein, Human, Recombinant (His)
Human E. coli
SMAD Family Member 4 (SMAD4) is a cytoplasmic protein that belongs to the Dwarfin/SMAD family. SMAD4 contains one MH1 (MAD homology 1) domain and one MH2 (MAD ho...
TMPJ-01226 Irisin Protein, Human/Mouse/Rat, Recombinant (hFc)
Irisin Protein, Human/Mouse/Rat, Recombinant (hFc)
Human,Mouse,Rat Human Cells
Fibronectin type III domain-containing protein 5, the precursor of irisin, is a protein that is encoded by the FNDC5 gene.Human Irisin is synthesized as a 212 am...
TMPJ-01227 Irisin Protein, Human/Mouse/Rat, Recombinant (C-His)
Irisin Protein, Human/Mouse/Rat, Recombinant (C-His)
Human,Mouse,Rat Human Cells
Fibronectin type III domain-containing protein 5, the precursor of irisin, is a protein that is encoded by the FNDC5 gene.Human Irisin is synthesized as a 212 am...
TMPJ-01228 Irisin Protein, Human/Mouse/Rat, Recombinant (N-His)
Irisin Protein, Human/Mouse/Rat, Recombinant (N-His)
Human,Mouse,Rat Human Cells
Irisin Protein, Human/Mouse/Rat, Recombinant (N-His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 18-28 KDa and the...
Artemin Protein, Human, Recombinant
TMPJ-00100
Human Artemin is a GDNF family ligand that is distantly related to the TGF-β superfamily of molecules. It is synthesized as a preproprotein, and contains a varia...
Lefty-A Protein, Human, Recombinant (His)
TMPJ-00238
Left-right determination factor 2(LEFTY2) is a secreted protein which belongs to the TGF-beta family. Lefty was first identified in a screen for undifferentiated...
LAP (TGF-beta 1) Protein, Human, Recombinant (His & Avi), Biotinylated
TMPJ-00250
Transforming growth factor beta (TGFβ) family members are secreted in inactive complexes with a latency-associated peptide (LAP), a protein derived from the N-te...
TGF beta 3 Protein, Human, Recombinant (Avi), Biotinylated
TMPJ-00255
Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell...
Latent TGF-beta 3 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPJ-00256
Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell...
TGF beta 2 Protein, Human, Recombinant (Avi), Biotinylated
TMPJ-00259
Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell...
Latent TGF-beta 2 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPJ-00260
Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell...
SMAD3 Protein, Human, Recombinant (His & Flag)
TMPJ-00271
Mothers against decapentaplegic homolog 3(SMAD3) is a cytoplasm protein which belongs to the dwarfin/SMAD family. Smad proteins undergo rapid nuclear translocati...
Latent TGF-beta 1 Protein, Cynomolgus, Recombinant (His)
TMPJ-00622
Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell...
GDF-8 Protein, Human/Mouse/Rat, Recombinant
TMPJ-00663
Growth/differentiation factor 8(Mstn, GDF-8) is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is c...
GDF-11 Protein, Human, Recombinant
TMPJ-00713
Growth/differentiation factor 11(GDF-11) is a secreted protein, which belongs to the transforming growth factor beta superfamily. GDF-11 controls anterior-poster...
TGF beta 1 Protein, Mouse/Rat, Recombinant
TMPJ-00771
Transforming growth factor beta 1 (TGFβ1) is the prototype of a growing superfamily of peptide growth factors and plays a prominent role in a variety of cellular...
Latent TGF-beta 1 Protein, Mouse, Recombinant (His & Avi), Biotinylated
TMPJ-00772
Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell...
GDF-5 Protein, Human, Recombinant
TMPJ-00966
Growth Differentiation Factor 5(GDF-5, BMP-14) is a member of the BMP family of TGFβ superfamily proteins. Human GDF-5, -6, and -7 are a defined subgroup of the ...
INHBC Protein, Human, Recombinant (C-His)
TMPJ-01015
Inhibin beta C chain, also known as activin beta-C chain and INHBC, belongs to the TGF-beta family. INHBC forms a homodimeric or heterodimeric through associatio...
INHBC Protein, Human, Recombinant (N-His)
TMPJ-01016
Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ ...
SMAD4 Protein, Human, Recombinant (His)
TMPJ-01108
SMAD Family Member 4 (SMAD4) is a cytoplasmic protein that belongs to the Dwarfin/SMAD family. SMAD4 contains one MH1 (MAD homology 1) domain and one MH2 (MAD ho...
Irisin Protein, Human/Mouse/Rat, Recombinant (hFc)
TMPJ-01226
Fibronectin type III domain-containing protein 5, the precursor of irisin, is a protein that is encoded by the FNDC5 gene.Human Irisin is synthesized as a 212 am...
Irisin Protein, Human/Mouse/Rat, Recombinant (C-His)
TMPJ-01227
Fibronectin type III domain-containing protein 5, the precursor of irisin, is a protein that is encoded by the FNDC5 gene.Human Irisin is synthesized as a 212 am...
Irisin Protein, Human/Mouse/Rat, Recombinant (N-His)
TMPJ-01228
Irisin Protein, Human/Mouse/Rat, Recombinant (N-His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 18-28 KDa and the...
1 2 3 4
TargetMol