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Tomatidine
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Catalog No. TMA0507Cas No. 77-59-8
Tomatidine serves as an anti-inflammatory agent by inhibiting NF-κB and JNK signaling pathways. Additionally, it induces autophagy in both mammalian cells and C. elegans.
Tomatidine
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Purity: 99.98%
Catalog No. TMA0507Cas No. 77-59-8
Tomatidine serves as an anti-inflammatory agent by inhibiting NF-κB and JNK signaling pathways. Additionally, it induces autophagy in both mammalian cells and C. elegans.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $42 | In Stock | In Stock | |
| 10 mg | $58 | In Stock | In Stock | |
| 25 mg | $115 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.98%
Appearance:Solid
Color:White
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Product Introduction
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| Description | Tomatidine serves as an anti-inflammatory agent by inhibiting NF-κB and JNK signaling pathways. Additionally, it induces autophagy in both mammalian cells and C. elegans. |
| In vitro | Staphylococcus aureus (S. aureus) is responsible for difficult-to-treat and relapsing infections and constitutes one of the most problematic pathogens due to its multiple resistances to clinically available antibiotics. Additionally, the ability of S. aureus to develop small-colony variants is associated with a reduced susceptibility to aminoglycoside antibiotics and in vivo persistence. METHODS AND RESULTS: We have recently demonstrated that Tomatidine, a steroid alkaloid isolated from tomato plants, possesses anti-virulence activity against normal strains of S. aureus as well as the ability to potentiate the effect of aminoglycoside antibiotics. In addition, Tomatidine has shown antibiotic activity against small-colony variants of S. aureus. CONCLUSIONS: We herein report the first study of the structure-activity relationship of Tomatidine against S. aureus. |
| Molecular Weight | 415.65 |
| Formula | C27H45NO2 |
| Cas No. | 77-59-8 |
| Smiles | CC1C2C(CC3C4CCC5CC(O)CCC5(C)C4CCC23C)OC11CCC(C)CN1 |
| Relative Density. | 1.0048 g/cm3 (Estimated) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||
| Solubility Information | 0.1 M HCl: < 1 mg/mL (insoluble) DMSO: 2.86 mg/mL (6.88 mM), Sonication is recommended. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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