Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Salvigenin is a potent hMAO-A inhibitor, has neuroprotective, antitumor and immunomodulatory effects.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 65.00 | |
5 mg | In stock | $ 159.00 | |
10 mg | In stock | $ 263.00 | |
25 mg | In stock | $ 447.00 | |
50 mg | In stock | $ 646.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 177.00 |
Description | Salvigenin is a potent hMAO-A inhibitor, has neuroprotective, antitumor and immunomodulatory effects. |
In vitro | Co-administration of flavonoids(eupatorin and salvigenin) with doxorubicin induced apoptosis via the mitochondrial pathway as mitochondrial membrane potential and ROS production were changed. Annexin/PI analysis demonstrated that apoptosis frequency was increased with the combination treatments in colon cancer cells. Finally, the combination of these flavonoids with doxorubicin increased the Bax/Bcl-2 ratio, caspase-3 expression and PARP cleavage[1]. |
Cell Research | Upon establishing a non-effective dose of doxorubicin, and effective doses of eupatorin (100μM) and salvigenin (150μM) via MTT, morphological features of apoptosis were distinguished using DAPI staining and cell cycle blockage in the sub-G1 phase. Apoptosis was determined by annexin/ PI and western blotting. ROS levels and MMP were measured to show any role of mitochondria in apoptosis[1]. |
Source |
Molecular Weight | 328.32 |
Formula | C18H16O6 |
CAS No. | 19103-54-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 4.4 mg/mL (13.4 mM)
You can also refer to dose conversion for different animals. More
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Salvigenin 19103-54-9 Autophagy Metabolism Neuroscience Tyrosine Kinase/Adaptors MAO ROS Kinase inhibit Apoptosis immunomodulatory Inhibitor neuroprotective antioxidant inhibitor