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SLC13A5-IN-1

Catalog No. T12931 CAS 2227548-95-8

SLC13A5-IN-1 is a selective inhibitor of sodium-citrate co-transporter (SLC13A5),completely blocks the uptake of 14C-citrate(IC50 : 0.022 μM in HepG2 cells).

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SLC13A5-IN-1, CAS 2227548-95-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 43.00
5 mg	In stock	$ 98.00
10 mg	In stock	$ 163.00
25 mg	In stock	$ 297.00
50 mg	In stock	$ 497.00
100 mg	In stock	$ 693.00
200 mg	In stock	$ 982.00
500 mg	In stock	$ 1,450.00
1 mL * 10 mM (in DMSO)	In stock	$ 123.00

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Description	SLC13A5-IN-1 is a selective inhibitor of sodium-citrate co-transporter (SLC13A5),completely blocks the uptake of 14C-citrate(IC50 : 0.022 μM in HepG2 cells).
Targets&IC50	HepG2/14C-Citrate uptake:0.022 μM , Recombinant hSLC3A5/14C-Citrate Uptake:0.056 μM
In vitro	In HepG2/14C-Citrate Uptake Assay,SLC13A5-IN-1 exhibits an IC50 of 0.022 μM . HepG2 cells endogenously express hSLC13A5 transporter which is responsible for the uptake of citrate into these cells. Uptake of 14C-citrate can be completely blocked by SLC13A5-IN-1 and the signal can be competed with unlabelled citrate.In recombinant hSLC3A5/14C-Citrate Uptake Assay, SLC13A5-IN-1 exhibits an IC50 of 0.056 μM . SLC13A5-IN-1 exhibits an IC50 of 100 μM in recombinant Human GlyT2/3H-Glycine Uptake Assay. The human embryonic kidney 293 cells are used that stably over-express the human GlyT2 receptor which is responsible for the uptake of glycine into these cells. Uptake of 3H-glycine can be completely blocked by SLC13A5-IN-1.

Molecular Weight	461.79
Formula	C19H19Cl3N2O3S
CAS No.	2227548-95-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 5 mg/ml (10.83 mM), Sonication is recommended.

References and Literature

1. Joerg Kley, et al. Sulfonamides as inhibitors of the uptake of extracellular citrate. Patent WO2018104220A1

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compounds Library Max Metabolism Compound Library Bioactive Compound Library

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Keywords

SLC13A5-IN-1 2227548-95-8 Metabolism Stearoyl-CoA Desaturase (SCD) hSLC3A5 metabolic SLC-13A5-IN-1 SLC13A5IN1 Inhibitor Citrate SLC13A5 cardiovascular inhibit disease Sodium Channel Uptake Na channels Na+ channels SLC13A5 IN 1 inhibitor

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