Home Tools

RGX-202

Catalog No. T7535 CAS 353-09-3

Synonyms: β-GPA, 3-Guanidinopropionic Acid

RGX-202 (β-GPA) is a creatine analog that alters skeletal muscle energy expenditure. It reduces cellular ATP, creatine, and phosphocreatine levels and stimulates AMP-activated protein kinase (AMPK), activating PPARγ coactivator 1α (PGC-1α).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

RGX-202, CAS 353-09-3

Pack Size	Availability	Price/USD
25 mg	In stock	$ 30.00
50 mg	In stock	$ 39.00
100 mg	In stock	$ 55.00
200 mg	In stock	$ 80.00
500 mg	In stock	$ 133.00
1 g	In stock	$ 195.00

Bulk Inquiry

Select Batch

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	RGX-202 (β-GPA) is a creatine analog that alters skeletal muscle energy expenditure. It reduces cellular ATP, creatine, and phosphocreatine levels and stimulates AMP-activated protein kinase (AMPK), activating PPARγ coactivator 1α (PGC-1α).
In vitro	3-Guanidinopropionic acid evokes a shift from glycolytic to oxidative metabolism, increased cellular glucose uptake, and increased fatigue tolerance[1]
In vivo	3-Guanidinopropionic Acid(β-GPA) downregulated the expression of the β-oxidation genes.?Administration of β-GPA in mice for 3 weeks improved the animals' physical strength and endurance health, ie, increased their physical strength and endurance and alleviated anxiety.?β-GPA might be considered an adaptogene affecting both the muscle and brain metabolism in mammals[2].
Animal Research	The following animal groups were used for the experiment: (1) mice that were not subjected to injections (n = 10)—this group was used only for physiological tests and were not killed after the experiment;?(2) saline-treated mice (n = 8)—the volume of injections was 200 μL;?and (3) β-GPA-treated mice (n = 8)—concentration of β-GPA was 1 mg/kg/day.?The volume of injections was 200 μL.Injections were performed 3 times a week for 3 weeks.?The mice's weight and the total amount of consumed food and water were measured daily.?Once a week, a string test was performed.?Measurements of the oxygen consumption rates of live animals and the open field test were performed after the course of injections.?After 3 weeks, the mice were killed;?brain dissection was performed to extract the cortex and the ventral midbrain (VMB) for quantitative real-time polymerase chain reaction (qRT-PCR) analysis[2].

Synonyms	β-GPA, 3-Guanidinopropionic Acid
Molecular Weight	131.13
Formula	C4H9N3O2
CAS No.	353-09-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Slightly soluble

References and Literature

1. Oudman I, Clark JF, Brewster LM.The effect of the creatine analogue beta-guanidinopropionic acid on energy metabolism: a systematic review.PLoS One. 2013;8(1):e52879. 2. Gureev A P , Shaforostova E A , Starkov A A , et al. β-Guanidinopropionic Acid Stimulates Brain Mitochondria Biogenesis and Alters Cognitive Behavior in Nondiseased Mid-Age Mice[J]. Journal of Experimental Neuroscience, 2018, 12:117906951876652.

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library Inhibitor Library DNA Damage & Repair Compound Library Anti-Hypertension Compound Library Nuclear Receptor Compound Library Anti-Pancreatic Cancer Compound Library Anti-Prostate Cancer Compound Library Bioactive Compounds Library Max Anti-Metabolism Disease Compound Library Pyroptosis Compound Library

Related Products

Related compounds with same targets

Phenformin hydrochloride Ganodermanondiol Methyl cinnamate Palmitelaidic Acid 7-Methoxyisoflavone Gomisin J RSS0680 Epiberberine

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

Step One: Enter information below

Dosage

mg/kg

Average weight of animals

Dosing volume per animal

Number of animals

Step Two: Enter the in vivo formulation

% DMSO+

% +

% Tween 80+

% ddH₂O

%DMSO+

Calculate Reset

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Calculator

Molarity Calculator

Dilution Calculator

Reconstitution Calculation

Molecular Weight Calculator

Mass

Concentration

Volume

Molecular Weight

Molarity Calculator allows you to calculate the

Mass of a compound required to prepare a solution of known volume and concentration
Volume of solution required to dissolve a compound of known mass to a desired concentration
Concentration of a solution resulting from a known mass of compound in a specific volume

See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

Concentration (Start)

Volume (Start)

Concentration (End)

Volume (End)

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Molecule Formula

Molecular Weight g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

RGX-202 353-09-3 Chromatin/Epigenetic DNA Damage/DNA Repair Metabolism PI3K/Akt/mTOR signaling AMPK PPAR cancer apoptosis inhibit beta-GPA creatine import b-GPA β-GPA Inhibitor RGX 202 oral 3-Guanidinopropionic Acid mice Endogenous Metabolite RGX202 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.