Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Ganodermanondiol exhibits potent cytoprotective effects on t-BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through Nrf2-mediated antioxidant enzymes and AMPK.
Description | Ganodermanondiol exhibits potent cytoprotective effects on t-BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through Nrf2-mediated antioxidant enzymes and AMPK. |
Targets&IC50 | HIV-1 protease:90μM (IC50) |
In vitro | Ganodermanondiol protected human liver-derived HepG2 cells through nuclear factor-E2-related factor 2 (Nrf2) pathway-dependent heme oxygenase-1 expressions. Moreover, Ganodermanondiol increased cellular glutathione levels and the expression of the glutamine-cysteine ligase gene in a dose-dependent manner. Furthermore, Ganodermanondiol exposure enhanced the phosphorylation of adenosine monophosphate-activated protein kinase (AMPK) and its upstream kinase activators, LKB1 and Ca(2+)/calmodulin-dependent protein kinase-II (CaMKII)[1] |
Synonyms | 灵芝酮二醇 |
Molecular Weight | 456.7 |
Formula | C30H48O3 |
CAS No. | 107900-76-5 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
( < 1 mg/ml refers to the product slightly soluble or insoluble )
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Ganodermanondiol 107900-76-5 PI3K/Akt/mTOR信号通路 蛋白酶体 免疫与炎症 微生物学 AMPK HIV Protease Nrf2 Inhibitor inhibitor inhibit