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Ganodermanondiol

Catalog No. TN1670 CAS 107900-76-5

Synonyms: 灵芝酮二醇

Ganodermanondiol exhibits potent cytoprotective effects on t-BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through Nrf2-mediated antioxidant enzymes and AMPK.

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Ganodermanondiol, CAS 107900-76-5

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Purity: 98%

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Description	Ganodermanondiol exhibits potent cytoprotective effects on t-BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through Nrf2-mediated antioxidant enzymes and AMPK.
Targets&IC50	HIV-1 protease:90μM (IC50)
In vitro	Ganodermanondiol protected human liver-derived HepG2 cells through nuclear factor-E2-related factor 2 (Nrf2) pathway-dependent heme oxygenase-1 expressions. Moreover, Ganodermanondiol increased cellular glutathione levels and the expression of the glutamine-cysteine ligase gene in a dose-dependent manner. Furthermore, Ganodermanondiol exposure enhanced the phosphorylation of adenosine monophosphate-activated protein kinase (AMPK) and its upstream kinase activators, LKB1 and Ca(2+)/calmodulin-dependent protein kinase-II (CaMKII)[1]

Synonyms	灵芝酮二醇
Molecular Weight	456.7
Formula	C30H48O3
CAS No.	107900-76-5

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

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( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Protective effect of ganodermanondiol isolated from the Lingzhi mushroom against tert-butyl hydroperoxide-induced hepatotoxicity through Nrf2-mediated antioxidant enzymes.Food Chem Toxicol. 2013 Mar;53:317-24.

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Keywords

Ganodermanondiol 107900-76-5 PI3K/Akt/mTOR信号通路蛋白酶体免疫与炎症微生物学 AMPK HIV Protease Nrf2 Inhibitor inhibitor inhibit

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