Powder: -20°C for 3 years | In solvent: -80°C for 1 year
QNZ (EVP4593) (EVP4593) is an effective inhibitor of NF-κB activation and TNF-α production. The IC50 of QNZ for NF-κB and TNF-α is11 nM and 7 nM, respectively.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 36.00 | |
2 mg | In stock | $ 52.00 | |
5 mg | In stock | $ 85.00 | |
10 mg | In stock | $ 143.00 | |
25 mg | In stock | $ 238.00 | |
50 mg | In stock | $ 347.00 | |
100 mg | In stock | $ 516.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 94.00 |
Description | QNZ (EVP4593) (EVP4593) is an effective inhibitor of NF-κB activation and TNF-α production. The IC50 of QNZ for NF-κB and TNF-α is11 nM and 7 nM, respectively. |
Targets&IC50 | TNF-α:7 nM |
In vitro | Intraperitoneal injection of EVP4593 (1 mg/kg) in rats suppressed carrageenan-induced paw edema in a dose-dependent manner. |
In vivo | In murine spleen cells stimulated by lipopolysaccharide, EVP4593 (IC50= nM) inhibits the production of TNF-α. In rat neutrophils, EVP4593 (10 nM) suppresses the upregulation of CSE expression induced by lipopolysaccharide. EVP4593 (40 nM) entirely inhibits the increase in the number and length of axons during laminin treatment in Schwann cell adhesion. Additionally, in IB4-negative neurons, EVP4593 (100 nM) blocks the induction effect of GRO/KC on K currents. |
Synonyms | CAY10470, EVP4593 |
Molecular Weight | 356.42 |
Formula | C22H20N4O |
CAS No. | 545380-34-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 5 mg/mL (14.02 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
QNZ 545380-34-5 Apoptosis NF-Κb TNF NF-κB TNFR CAY-10470 EVP-4593 Inhibitor Nuclear factor-kappaB CAY10470 EVP 4593 inhibit Tumor Necrosis Factor Receptor Nuclear factor-κB CAY 10470 TNF Receptor EVP4593 inhibitor