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Prochloraz

Catalog No. T20625 CAS 67747-09-5

Synonyms: Sporgon, 咪鲜胺, Prelude

Prochloraz is a broad-spectrum contact imidazole fungicide. Prochloraz inhibits human placental microsomal aromatase in vitro (IC50 = 40 nM). Prochloraz also acts as an estrogen receptor (IC50s = 25 μM) and androgen receptor (IC50 = 4 μM) antagonist, and activates aryl hydrocarbon receptors (EC50 = 1 μM).

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Prochloraz, CAS 67747-09-5

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Prochloraz is a broad-spectrum contact imidazole fungicide. Prochloraz inhibits human placental microsomal aromatase in vitro (IC50 = 40 nM). Prochloraz also acts as an estrogen receptor (IC50s = 25 μM) and androgen receptor (IC50 = 4 μM) antagonist, and activates aryl hydrocarbon receptors (EC50 = 1 μM).
Targets&IC50	Estrogen Receptor/ERR:25 μM, Antifungal:40 nM, AhR:1 μM(EC50), Androgen Receptor:4 μM

Synonyms	Sporgon, 咪鲜胺, Prelude
Molecular Weight	376.67
Formula	C15H16Cl3N3O2
CAS No.	67747-09-5

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: Soluble

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Liu J, et al. Whole transcriptome analysis of Penicillium digitatum strains treatmented with prochloraz reveals their drug-resistant mechanisms. BMC Genomics. 2015 Oct 24;16:855. 2. Alpertunga B, et al. Effects of prochloraz on DNA damage, lipid peroxidation and antioxidant system in vitro. Toxicol Mech Methods. 2014 May;24(4):268-75. 3. Baumann L, et al. Prochloraz causes irreversible masculinization of zebrafish (Danio rerio). Environ Sci Pollut Res Int. 2015 Nov;22(21):16417-22. 4. Lundqvist J, et al. Fungicide prochloraz induces oxidative stress and DNA damage in vitro. Food Chem Toxicol. 2016 May;91:36-41.

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Keywords

Prochloraz 67747-09-5 代谢免疫与炎症内分泌与激素微生物学 AhR Androgen Receptor Antifungal Estrogen Receptor/ERR biosynthesis placenta hydrocarbon imidazole Inhibitor microsomal Aryl Hydrocarbon Receptor Fungal BTS-40542 ergosterol inhibit Prelude BTS 40542 aromatase,estrogen antifungal aryl Sporgon androgen human BTS40542 inhibitor

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