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Nicardipine hydrochloride

Catalog No. T1215 CAS 54527-84-3

Synonyms: RS-69216, Nicardipine HCl, YC-93 Hydrochloride

Nicardipine hydrochloride (YC-93 Hydrochloride) is the hydrochloride salt form of nicardipine, a synthetic derivative of nitrophenyl-pyridine and potent calcium channel blocker, Nicardipine (Nifedipine Family) blocks calcium ions from certain cell walls and inhibits contraction of coronary and peripheral arteries, resulting in lowered oxygen requirements for heart muscle and decreased arterial contraction and spasm. It is used clinically as a cerebral and coronary vasodilator.

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Nicardipine hydrochloride Chemical Structure

Nicardipine hydrochloride, CAS 54527-84-3

Pack Size	Availability	Price/USD
500 mg	In stock	$ 41.00
1 g	In stock	$ 48.00
1 mL * 10 mM (in DMSO)	In stock	$ 45.00

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Purity: 100%

Purity: 99.89%

Purity: 99.87%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Targets&IC50

Ca2+ channel (Cardiac):1 μM (IC50)

Synonyms	RS-69216, Nicardipine HCl, YC-93 Hydrochloride
Molecular Weight	515.99
Formula	C26H30ClN3O6
CAS No.	54527-84-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 93 mg/mL (180.2 mM)

References and Literature

1. Harino S, et al. Invest Ophthalmol Vis Sci, 1992, 33(10), 2885-2890. 2. Amenta F, et al. J Hypertens Suppl, 1996, 14(3), S29-35. 3. Willis AL, et al. Arteriosclerosis, 1985, 5(3), 250-255. 4. Gasior M, et al. J Neural Transm, 1996, 103(7), 819-831.

Citations

1. Wang B, Pei J, Zhang H, et al.Dihydropyridine-derived calcium channel blocker as a promising anti-hantavirus entry inhibitor.Interventions for emerging infectious diseases.2023, 16648714.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Approved Drug Library GPCR Compound Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Anti-Neurodegenerative Disease Compound Library Inhibitor Library Drug Repurposing Compound Library Adrenergic Receptor-Targeted Compound Library Anti-Parkinson's Disease Compound Library Autophagy Compound Library

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Related compounds with same targets

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Nicardipine hydrochloride 54527-84-3 Autophagy GPCR/G Protein Membrane transporter/Ion channel Metabolism Neuroscience Adrenergic Receptor AChR Calcium Channel Ca channels Nicardipine Ca2+ channels RS-69216 RS 69216 blocker inhibit blood YC93 Inhibitor RS69216 Nicardipine Hydrochloride pressure angina YC-93 YC 93 Nicardipine HCl cardiac YC 93 Hydrochloride YC93 Hydrochloride YC-93 Hydrochloride inhibitor

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