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Hycanthone

Catalog No. T15507 CAS 3105-97-3

Synonyms: Etrenol(mesylate), Win 249-33

Hycanthone (Etrenol(mesylate)) is a potent drug of antischistosomal. Hycanthone is a DNA intercalator that inhibits RNA synthesis and DNA topoisomerases I and II. Hycanthone inhibits nucleic acid biosynthesis and inhibits APE1 via direct protein binding(KD: 10 nM).

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Hycanthone, CAS 3105-97-3

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5 mg	In stock	$ 32.00
10 mg	In stock	$ 50.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 98.78%

Biological Description

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Storage & Solubility Information

Description	Hycanthone (Etrenol(mesylate)) is a potent drug of antischistosomal. Hycanthone is a DNA intercalator that inhibits RNA synthesis and DNA topoisomerases I and II. Hycanthone inhibits nucleic acid biosynthesis and inhibits APE1 via direct protein binding(KD: 10 nM).
Targets&IC50	APE1:10 nM(Kd)
In vitro	Hycanthone at 20 mg/mL or more is progressively more detrimental to cell viability. Compared to that of controls, results show that increased concentrations of Hycanthone, ranging from 0.1 to 10 μg/mL, progressively decreases viral interferon yields as much as 73% [2].
In vivo	Male worms treated with Hycanthone display signs of possible partial recovery from the initial low levels of incorporation. After treatment with Hycanthone, the incorporation of tritiated thymidine into TCA-precipitable material of adult sensitive worms undergo a progressive decrease. Immature worms are totally unaffected by Hycanthone at all times tested. In the first four days after treatment, incorporation of tritiated leucine by drug-sensitive worms treated with Hycanthone is inhibited by 40 to 50%. 7 days after Hycanthone treatment, both ribosomal RNA species are reduced by at least 80% with respect to untreated worms, with some indication of a possible accumulation of heavier precursor molecules [1].

Synonyms	Etrenol(mesylate), Win 249-33
Molecular Weight	356.48
Formula	C20H24N2O2S
CAS No.	3105-97-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 0.1 mg/mL (insoluble)

DMSO: 18 mg/mL (50.49 mM), Sonication is recommended.

References and Literature

1. Pica Mattoccia L, et al. Effect of hycanthone administered in vivo upon the incorporation of radioactive precursors into macromolecules of Schistosoma mansoni. Mol Biochem Parasitol. 1983 Jun;8(2):99-107. 2. Hahon N, et al. Action of antischistosomal drugs, hycanthone and its analog 1A-4 N-oxide, on viral interferon induction. J Toxicol Environ Health. 1980 Jul;6(4):705-12.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Parasitic Compound Library Drug Repurposing Compound Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Anti-Cancer Active Compound Library Clinical Compound Library Human Metabolite Library ReFRAME Related Library DNA Damage & Repair Compound Library Bioactive Compounds Library Max

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Keywords

Hycanthone 3105-97-3 Cell Cycle/Checkpoint DNA Damage/DNA Repair Microbiology/Virology Topoisomerase DNA/RNA Synthesis Parasite APE1 inhibit acid intercalator Etrenol(mesylate) Lucanthone anti-schistosomal Win 249-33 nucleic apurinic endonuclease-1 biosynthesis Inhibitor thioxanthenone inhibitor

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