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Arctigenin
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Catalog No. T2957Cas No. 7770-78-7
Alias (-)-Arctigenin
(-)-Arctigenin ((-)-Arctigenin) is found in burdock. (-)-Arctigenin is isolated from Cnicus benedictus, Forsythia viridissima, Arctium lappa, Ipomoea cairica and others (CCD). Arctigenin is a lignan found in certain plants of the Asteraceae, including the Greater burdock (Arctium lappa) and Saussurea heteromalla. It has shown antiviral and anticancer effects. It is the aglycone of arctiin.
Arctigenin
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Purity: 99.51%
Catalog No. T2957Alias (-)-ArctigeninCas No. 7770-78-7
(-)-Arctigenin ((-)-Arctigenin) is found in burdock. (-)-Arctigenin is isolated from Cnicus benedictus, Forsythia viridissima, Arctium lappa, Ipomoea cairica and others (CCD). Arctigenin is a lignan found in certain plants of the Asteraceae, including the Greater burdock (Arctium lappa) and Saussurea heteromalla. It has shown antiviral and anticancer effects. It is the aglycone of arctiin.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $31 | In Stock | In Stock | |
| 50 mg | $44 | In Stock | In Stock | |
| 100 mg | $73 | In Stock | In Stock | |
| 500 mg | $176 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $48 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.51%
Appearance:Solid
Color:White
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Product Introduction
Arctigenin AI Summary
Arctigenin exhibits a broad range of bioactivities with potential therapeutic applications. It shows inhibitory activity against HIV-1 Integrase at 100 μM, although with moderate efficacy (<5.0% inhibition) and exhibits antiviral activity against HIV by reducing viral protein production at low concentrations (0.27 μM and 0.52 μM). It has a significant activity against HIV1-infected human H9 cells with an EC50 of 420.0 nM.
The compound also presents potent inhibitory activity against MKK1 (IC50 = 1.0 nM) and LPS-induced iNOS expression in mouse Raw264.7 cells (IC50 = 10.0 nM). It demonstrates anti-inflammatory properties by inhibiting nitric oxide production in RAW264.7 cells with an IC50 of 260 μM and shows cytotoxicity against MRC5 cells (CC50 = 76 μM) and human pancreatic cancer cells (e.g., PANC1, PSN1, MIAPaCa2, KLM1), particularly under nutrient-deprived conditions (PC50 = 0.7 μM to 1.9 μM).
In addition, Arctigenin displays antiproliferative activities against various cancer cell lines (HepG2, MDA-MB-231, A549) and cytotoxicity against human HL60 cells, albeit with differential selectivity. It exhibits specific inhibitory effects on SARS-CoV-2 induced cytotoxicity of Caco-2 cells and demonstrates activity in glucose uptake assays in rat L6 cells, suggesting a potential role in metabolic modulation.
Furthermore, Arctigenin shows inhibitory activity against SARS-CoV-2 3CL-Pro protease and anti-austerity activity in human pancreatic cancer cell lines under nutrient-deprived conditions, with a notable PC50 value of around 0.8 μM. It also exhibits potent inhibitory activity against the Cytochrome P450 enzyme family and various signaling pathways, including the ERK signaling pathway.
Overall, Arctigenin shows promising effectiveness across various biological assays, indicating its potential as a multi-target therapeutic candidate..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | (-)-Arctigenin ((-)-Arctigenin) is found in burdock. (-)-Arctigenin is isolated from Cnicus benedictus, Forsythia viridissima, Arctium lappa, Ipomoea cairica and others (CCD). Arctigenin is a lignan found in certain plants of the Asteraceae, including the Greater burdock (Arctium lappa) and Saussurea heteromalla. It has shown antiviral and anticancer effects. It is the aglycone of arctiin. |
| Synonyms | (-)-Arctigenin |
| Molecular Weight | 372.41 |
| Formula | C21H24O6 |
| Cas No. | 7770-78-7 |
| Smiles | C([C@@H]1[C@@H](CC2=CC(OC)=C(OC)C=C2)COC1=O)C3=CC(OC)=C(O)C=C3 |
| Relative Density. | 1.227 g/cm3 (Predicted) |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 255 mg/mL (684.73 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (13.43 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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